| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Baker Bros Advisors LP | 19.92M (50.92%) | 2.61M Increased by +13.10% | Dec 31, 25 |
| 2 | BlackRock Inc | 2.95M (7.55%) | -627.06K Decreased by -21.24% | Sep 30, 25 |
| 3 | Vanguard Group Inc | 2.31M (5.91%) | 363.10K Increased by +15.70% | Dec 31, 25 |
| 4 | Point72 Asset Management, L.P. | 2.17M (5.54%) | -670.19K Decreased by -30.93% | Dec 31, 25 |
| 5 | BRAIDWELL LP | 2.07M (5.30%) | 2.07M Increased by +100.00% | Dec 31, 25 |
| 6 | EcoR1 Capital, LLC | 1.61M (4.12%) | 1.61M Increased by +100.00% | Mar 31, 24 |
| 7 | RTW INVESTMENTS, LLC | 1.49M (3.80%) | 1.49M Increased by +100.00% | Dec 31, 25 |
| 8 | TCG Crossover Management, LLC | 1.45M (3.70%) | 300.00K Increased by +20.75% | Dec 31, 25 |
| 9 | The Goldman Sachs Group Inc | 1.30M (3.33%) | 976.25K Increased by +74.92% | Dec 31, 25 |
| 10 | ICONIQ Capital, LLC | 1.27M (3.24%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 11 | Boxer Capital Management, LLC | 1.14M (2.90%) | 386.00K Increased by +33.98% | Dec 31, 25 |
| 12 | SILVERARC CAPITAL MANAGEMENT, LLC | 1.02M (2.62%) | 23.12K Increased by +2.26% | Dec 31, 25 |
| 13 | Acadian Asset Management LLC | 969.91K (2.48%) | 949.38K Increased by +97.88% | Sep 30, 25 |
| 14 | Geode Capital Management, LLC | 897.69K (2.29%) | 96.25K Increased by +10.72% | Dec 31, 25 |
| 15 | Artisan Partners Limited Partnership | 836.51K (2.14%) | 836.51K Increased by +100.00% | Dec 31, 25 |
| 16 | State Street Corp | 832.44K (2.13%) | -4.78K Decreased by -0.57% | Sep 30, 25 |
| 17 | Adage Capital Partners Gp LLC | 785.00K (2.01%) | -550.00K Decreased by -70.06% | Dec 31, 25 |
| 18 | Renaissance Technologies Corp | 764.14K (1.95%) | 61.54K Increased by +8.05% | Jun 30, 25 |
| 19 | State Street Corporation | 747.50K (1.91%) | 27.06K Increased by +3.62% | Mar 31, 24 |
| 20 | Newtyn Management LLC | 740.50K (1.89%) | -189.50K Decreased by -25.59% | Sep 30, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | State Street® SPDR® S&P® Biotech ETF | 1.34M (3.44%) | 20.23K Increased by +1.51% | Mar 31, 26 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 1.23M (3.14%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 3 | Vanguard US Total Market Shares ETF | 982.01K (2.51%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | iShares Russell 2000 ETF | 914.27K (2.34%) | -7.47K Decreased by -0.82% | Mar 31, 26 |
| 5 | BlackRock Advantage Small Cap Core Instl | 523.83K (1.34%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 6 | Artisan International Small-Mid Investor | 516.03K (1.32%) | 516.03K Increased by +100.00% | Dec 31, 25 |
| 7 | Artisan Non-U.S. Small-Mid Growth Comp | 516.03K (1.32%) | 516.03K Increased by +100.00% | Dec 31, 25 |
| 8 | Vanguard Institutional Extnd Mkt Idx Tr | 430.73K (1.10%) | 2.12K Increased by +0.49% | Feb 28, 26 |
| 9 | iShares Biotechnology ETF | 423.31K (1.08%) | 878.00 Increased by +0.21% | Mar 31, 26 |
| 10 | iShares Russell 2000 Value ETF | 324.24K (0.83%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 11 | Fidelity Small Cap Index | 317.16K (0.81%) | -3.88K Decreased by -1.22% | Jan 31, 26 |
| 12 | Fidelity® Small Cap Index | 302.77K (0.77%) | 5.66K Increased by +1.87% | Oct 31, 23 |
| 13 | Federated Hermes MDT SCC Institutional | 244.23K (0.62%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 14 | Federated Hermes MDT Small Cap Core IS | 244.23K (0.62%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 15 | BGF World Healthscience A2 | 225.29K (0.58%) | 225.29K Increased by +100.00% | Dec 31, 25 |
| 16 | State St Russell Sm/Mid Cp® Indx NL Cl C | 225.22K (0.58%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 17 | State St Russell Sm/Mid Cp® Indx SL Cl I | 225.22K (0.58%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 18 | T. Rowe Price Small-Cap Value | 223.69K (0.57%) | 223.69K Increased by +100.00% | Jan 31, 26 |
| 19 | Fidelity Extended Market Index | 206.19K (0.53%) | -63.00 Decreased by -0.03% | Feb 28, 26 |
| 20 | Schwab US Small-Cap ETF™ | 194.82K (0.50%) | 0.00 Increased by 0.00% | Mar 31, 26 |