| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Aberdeen Group PLC | 8.24M (12.63%) | 7.18M Increased by +87.15% | Jun 30, 25 |
| 2 | Bvf Inc | 7.65M (11.73%) | -1.25M Decreased by -16.33% | Jun 30, 25 |
| 3 | Soleus Capital Management, L.P. | 7.29M (11.18%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 4 | Avidity Partners Management LP | 5.62M (8.61%) | 1.16M Increased by +20.68% | Jun 30, 25 |
| 5 | Vanguard Group Inc | 4.13M (6.32%) | 193.60K Increased by +4.69% | Jun 30, 25 |
| 6 | HHG PLC | 2.69M (4.12%) | -2.41M Decreased by -89.63% | Dec 31, 24 |
| 7 | The Colony Group LLC | 2.58M (3.96%) | -1.75M Decreased by -67.86% | Mar 31, 25 |
| 8 | Gratus Capital LLC | 2.11M (3.23%) | 56.86K Increased by +2.70% | Jun 30, 24 |
| 9 | LAURION CAPITAL MANAGEMENT LP | 1.91M (2.92%) | 1.68M Increased by +88.01% | Jun 30, 25 |
| 10 | Omega Fund Management LLC | 1.79M (2.74%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 11 | Adage Capital Partners Gp LLC | 1.40M (2.14%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 12 | Geode Capital Management, LLC | 976.15K (1.50%) | 23.86K Increased by +2.44% | Mar 31, 25 |
| 13 | Susquehanna International Group, LLP | 949.65K (1.46%) | 65.91K Increased by +6.94% | Mar 31, 25 |
| 14 | Ikarian Capital, LLC | 914.17K (1.40%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 15 | 683 Capital Management LLC | 900.00K (1.38%) | 200.00K Increased by +22.22% | Mar 31, 25 |
| 16 | BlackRock Inc | 757.13K (1.16%) | -27.09K Decreased by -3.58% | Mar 31, 25 |
| 17 | Renaissance Technologies Corp | 669.46K (1.03%) | 102.84K Increased by +15.36% | Mar 31, 25 |
| 18 | Millennium Management LLC | 579.68K (0.89%) | 479.85K Increased by +82.78% | Dec 31, 24 |
| 19 | Morgan Stanley - Brokerage Accounts | 567.61K (0.87%) | -537.14K Decreased by -94.63% | Mar 31, 25 |
| 20 | Marshall Wace Asset Management Ltd | 563.54K (0.86%) | 145.66K Increased by +25.85% | Mar 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | abrdn Healthcare Investors | 4.74M (7.26%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 2 | abrdn Life Sciences Investors | 3.03M (4.64%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 3 | Vanguard US Total Market Shares ETF | 2.63M (4.03%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | Vanguard Total Stock Mkt Idx Inv | 2.57M (3.94%) | -56.78K Decreased by -2.21% | Jul 31, 25 |
| 5 | Pictet Biopharmaceutical Mother | 1.20M (1.84%) | 572.67K Increased by +47.72% | Apr 13, 23 |
| 6 | Vanguard Institutional Extnd Mkt Idx Tr | 957.46K (1.47%) | -436.29K Decreased by -45.57% | Jul 31, 25 |
| 7 | Fidelity Extended Market Index | 495.70K (0.76%) | 4.85K Increased by +0.98% | Jul 31, 25 |
| 8 | abrdn World Healthcare | 476.25K (0.73%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 9 | BlackRock Extended Equity Market K | 232.59K (0.36%) | -99.00 Decreased by -0.04% | Sep 30, 24 |
| 10 | Extended Equity Market Fund K | 225.63K (0.35%) | -4.50K Decreased by -2.00% | Jun 30, 25 |
| 11 | iShares Micro-Cap ETF | 213.35K (0.33%) | 0.00 Increased by 0.00% | Aug 29, 25 |
| 12 | Fidelity Total Market Index | 160.00K (0.25%) | -341.00 Decreased by -0.21% | Jul 31, 25 |
| 13 | A4Investments SICAV SIF ACCI IlanaA2EURH | 150.00K (0.23%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 14 | Fidelity® Extended Market Index | 137.75K (0.21%) | -76.62K Decreased by -55.62% | Oct 31, 23 |
| 15 | Vifag 2002 SICAV | 130.00K (0.20%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 16 | Fidelity Series Total Market Index | 125.65K (0.19%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 17 | BlackRock Extended Mkt Composite | 116.40K (0.18%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 18 | Bridgeway Ultra-Small Company Market | 115.00K (0.18%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 19 | NT Ext Equity Mkt Idx Fd - NL | 110.82K (0.17%) | 28.04K Increased by +25.30% | Jun 30, 25 |
| 20 | Spartan Extended Market Index Pool F | 107.06K (0.16%) | 4.08K Increased by +3.81% | Jul 31, 25 |