| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Bvf Inc | 8.90M (11.67%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 2 | Soleus Capital Management, L.P. | 7.29M (9.56%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 3 | RTW INVESTMENTS, LLC | 4.57M (5.99%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 4 | Avidity Partners Management LP | 4.45M (5.84%) | -3.51M Decreased by -78.84% | Mar 31, 25 |
| 5 | Vanguard Group Inc | 3.93M (5.15%) | 7.79K Increased by +0.20% | Mar 31, 25 |
| 6 | HHG PLC | 2.69M (3.53%) | -2.41M Decreased by -89.63% | Dec 31, 24 |
| 7 | The Colony Group LLC | 2.58M (3.39%) | -1.75M Decreased by -67.86% | Mar 31, 25 |
| 8 | Gratus Capital LLC | 2.11M (2.77%) | 56.86K Increased by +2.70% | Jun 30, 24 |
| 9 | Omega Fund Management LLC | 1.79M (2.34%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 10 | Adage Capital Partners Gp LLC | 1.40M (1.83%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 11 | Aberdeen Group PLC | 1.06M (1.39%) | 1.06M Increased by +100.00% | Mar 31, 25 |
| 12 | Geode Capital Management, LLC | 976.15K (1.28%) | 23.86K Increased by +2.44% | Mar 31, 25 |
| 13 | Susquehanna International Group, LLP | 949.65K (1.25%) | 65.91K Increased by +6.94% | Mar 31, 25 |
| 14 | Ikarian Capital, LLC | 914.17K (1.20%) | -700.00K Decreased by -76.57% | Mar 31, 25 |
| 15 | 683 Capital Management LLC | 900.00K (1.18%) | 200.00K Increased by +22.22% | Mar 31, 25 |
| 16 | BlackRock Inc | 757.13K (0.99%) | -27.09K Decreased by -3.58% | Mar 31, 25 |
| 17 | Renaissance Technologies Corp | 669.46K (0.88%) | 102.84K Increased by +15.36% | Mar 31, 25 |
| 18 | Millennium Management LLC | 579.68K (0.76%) | 479.85K Increased by +82.78% | Dec 31, 24 |
| 19 | Morgan Stanley - Brokerage Accounts | 567.61K (0.74%) | -537.14K Decreased by -94.63% | Mar 31, 25 |
| 20 | Marshall Wace Asset Management Ltd | 563.54K (0.74%) | 145.66K Increased by +25.85% | Mar 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | abrdn Healthcare Investors | 4.74M (6.21%) | 385.62K Increased by +8.14% | Jun 30, 25 |
| 2 | abrdn Life Sciences Investors | 3.03M (3.97%) | 171.49K Increased by +5.66% | Jun 30, 25 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 2.63M (3.45%) | 0.00 Increased by 0.00% | May 31, 25 |
| 4 | Vanguard US Total Market Shares ETF | 2.63M (3.45%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 5 | Vanguard Institutional Extnd Mkt Idx Tr | 1.39M (1.83%) | 0.00 Increased by 0.00% | May 31, 25 |
| 6 | Pictet Biopharmaceutical Mother | 1.20M (1.57%) | 572.67K Increased by +47.72% | Apr 13, 23 |
| 7 | Fidelity Extended Market Index | 492.13K (0.65%) | -2.20K Decreased by -0.45% | May 31, 25 |
| 8 | abrdn World Healthcare | 362.94K (0.48%) | 362.94K Increased by +100.00% | May 31, 25 |
| 9 | BlackRock Extended Equity Market K | 232.59K (0.30%) | -99.00 Decreased by -0.04% | Sep 30, 24 |
| 10 | Extended Equity Market Fund K | 225.63K (0.30%) | -4.50K Decreased by -2.00% | Jun 30, 25 |
| 11 | iShares Micro-Cap ETF | 215.03K (0.28%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 12 | Fidelity Total Market Index | 160.34K (0.21%) | 0.00 Increased by 0.00% | May 31, 25 |
| 13 | A4Investments SICAV SIF ACCI IlanaA2EURH | 150.00K (0.20%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 14 | Fidelity® Extended Market Index | 137.75K (0.18%) | -76.62K Decreased by -55.62% | Oct 31, 23 |
| 15 | Vifag 2002 SICAV | 130.00K (0.17%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 16 | Fidelity Series Total Market Index | 125.65K (0.16%) | 0.00 Increased by 0.00% | May 31, 25 |
| 17 | BlackRock Extended Mkt Composite | 116.40K (0.15%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 18 | Bridgeway Ultra-Small Company Market | 115.00K (0.15%) | -100.00K Decreased by -86.96% | Mar 31, 25 |
| 19 | NT Ext Equity Mkt Idx Fd - NL | 110.82K (0.15%) | 28.04K Increased by +25.30% | Jun 30, 25 |
| 20 | Spartan Extended Market Index Pool F | 102.98K (0.14%) | 1.05K Increased by +1.02% | May 31, 25 |