| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Aberdeen Group PLC | 8.24M (6.81%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | Bvf Inc | 7.65M (6.32%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | Vanguard Group Inc | 5.02M (4.15%) | 675.23K Increased by +13.45% | Dec 31, 25 |
| 4 | Avidity Partners Management LP | 4.70M (3.88%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 5 | Nantahala Capital Management, LLC | 4.38M (3.62%) | 4.38M Increased by +100.00% | Dec 31, 25 |
| 6 | LAURION CAPITAL MANAGEMENT LP | 3.88M (3.21%) | 2.00M Increased by +51.52% | Dec 31, 25 |
| 7 | Millennium Management LLC | 3.42M (2.82%) | 2.89M Increased by +84.49% | Dec 31, 25 |
| 8 | Morgan Stanley - Brokerage Accounts | 3.10M (2.56%) | -525.41K Decreased by -16.93% | Sep 30, 25 |
| 9 | HHG PLC | 2.69M (2.22%) | -2.41M Decreased by -89.63% | Dec 31, 24 |
| 10 | The Colony Group LLC | 2.62M (2.17%) | 40.88K Increased by +1.56% | Dec 31, 25 |
| 11 | Gratus Capital LLC | 2.11M (1.74%) | 56.86K Increased by +2.70% | Jun 30, 24 |
| 12 | Omega Fund Management LLC | 1.79M (1.48%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 13 | Soleus Capital Management, L.P. | 1.58M (1.30%) | -5.71M Decreased by -361.58% | Sep 30, 25 |
| 14 | Adage Capital Partners Gp LLC | 1.40M (1.16%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 15 | Geode Capital Management, LLC | 1.18M (0.97%) | 142.51K Increased by +12.12% | Dec 31, 25 |
| 16 | Marshall Wace Asset Management Ltd | 1.02M (0.84%) | 486.47K Increased by +47.69% | Dec 31, 25 |
| 17 | 683 Capital Management LLC | 900.00K (0.74%) | 200.00K Increased by +22.22% | Mar 31, 25 |
| 18 | Ghisallo Capital Management LLC | 835.00K (0.69%) | 835.00K Increased by +100.00% | Jun 30, 25 |
| 19 | BlackRock Inc | 725.74K (0.60%) | 27.00K Increased by +3.72% | Sep 30, 25 |
| 20 | Ikarian Capital, LLC | 674.66K (0.56%) | -239.51K Decreased by -35.50% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | abrdn Healthcare Investors | 4.74M (3.91%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 3.09M (2.55%) | 524.03K Increased by +16.97% | Feb 28, 26 |
| 3 | abrdn Life Sciences Investors | 3.03M (2.50%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 4 | Vanguard US Total Market Shares ETF | 2.63M (2.17%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 5 | Vanguard Institutional Extnd Mkt Idx Tr | 1.36M (1.12%) | -157.92K Decreased by -11.60% | Feb 28, 26 |
| 6 | Pictet Biopharmaceutical Mother | 1.20M (0.99%) | 572.67K Increased by +47.72% | Apr 13, 23 |
| 7 | Fidelity Extended Market Index | 645.88K (0.53%) | -2.68K Decreased by -0.42% | Jan 31, 26 |
| 8 | abrdn World Healthcare | 476.25K (0.39%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 9 | Simplify Propel Opportunities ETF | 354.81K (0.29%) | 352.33K Increased by +99.30% | Feb 27, 26 |
| 10 | Blackrock Extended Mkt Fund CF | 266.88K (0.22%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 11 | iShares Micro-Cap ETF | 257.03K (0.21%) | 198.65K Increased by +77.29% | Feb 28, 26 |
| 12 | BlackRock Extended Equity Market K | 232.59K (0.19%) | -99.00 Decreased by -0.04% | Sep 30, 24 |
| 13 | Extended Equity Market Fund K | 228.91K (0.19%) | 149.00 Increased by +0.07% | Dec 31, 25 |
| 14 | Fidelity Total Market Index | 158.68K (0.13%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 15 | BlackRock Global Equity Mkt Netrl Instl | 155.49K (0.13%) | 155.49K Increased by +100.00% | Feb 28, 26 |
| 16 | A4Investments SICAV SIF ACCI IlanaA2EURH | 150.00K (0.12%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 17 | Fidelity® Extended Market Index | 137.75K (0.11%) | -76.62K Decreased by -55.62% | Oct 31, 23 |
| 18 | Vifag 2002 SICAV | 130.00K (0.11%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 19 | Fidelity Series Total Market Index | 128.71K (0.11%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 20 | Spartan Extended Market Index Pool F | 118.83K (0.10%) | 2.68K Increased by +2.26% | Jan 31, 26 |