| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Aberdeen Group PLC | 8.24M (8.10%) | 7.18M Increased by +87.15% | Jun 30, 25 |
| 2 | Bvf Inc | 7.65M (7.52%) | -1.25M Decreased by -16.33% | Jun 30, 25 |
| 3 | Soleus Capital Management, L.P. | 7.29M (7.17%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 4 | Avidity Partners Management LP | 5.62M (5.52%) | 1.16M Increased by +20.68% | Jun 30, 25 |
| 5 | Vanguard Group Inc | 4.13M (4.05%) | 193.60K Increased by +4.69% | Jun 30, 25 |
| 6 | Morgan Stanley - Brokerage Accounts | 3.63M (3.57%) | 3.06M Increased by +84.36% | Jun 30, 25 |
| 7 | HHG PLC | 2.69M (2.64%) | -2.41M Decreased by -89.63% | Dec 31, 24 |
| 8 | The Colony Group LLC | 2.54M (2.50%) | -40.93K Decreased by -1.61% | Jun 30, 25 |
| 9 | Gratus Capital LLC | 2.11M (2.07%) | 56.86K Increased by +2.70% | Jun 30, 24 |
| 10 | LAURION CAPITAL MANAGEMENT LP | 1.91M (1.87%) | 1.68M Increased by +88.01% | Jun 30, 25 |
| 11 | Omega Fund Management LLC | 1.79M (1.76%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 12 | Adage Capital Partners Gp LLC | 1.40M (1.37%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 13 | Geode Capital Management, LLC | 974.64K (0.96%) | -1.52K Decreased by -0.16% | Jun 30, 25 |
| 14 | Susquehanna International Group, LLP | 949.65K (0.93%) | 65.91K Increased by +6.94% | Mar 31, 25 |
| 15 | Ikarian Capital, LLC | 914.17K (0.90%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 16 | 683 Capital Management LLC | 900.00K (0.88%) | 200.00K Increased by +22.22% | Mar 31, 25 |
| 17 | Ghisallo Capital Management LLC | 835.00K (0.82%) | 835.00K Increased by +100.00% | Jun 30, 25 |
| 18 | BlackRock Inc | 698.74K (0.69%) | -58.39K Decreased by -8.36% | Jun 30, 25 |
| 19 | Millennium Management LLC | 579.68K (0.57%) | 479.85K Increased by +82.78% | Dec 31, 24 |
| 20 | Marshall Wace Asset Management Ltd | 563.54K (0.55%) | 145.66K Increased by +25.85% | Mar 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | abrdn Healthcare Investors | 4.74M (4.66%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 2 | abrdn Life Sciences Investors | 3.03M (2.98%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 3 | Vanguard US Total Market Shares ETF | 2.63M (2.58%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | Vanguard Total Stock Mkt Idx Inv | 2.57M (2.53%) | -56.78K Decreased by -2.21% | Jul 31, 25 |
| 5 | Pictet Biopharmaceutical Mother | 1.20M (1.18%) | 572.67K Increased by +47.72% | Apr 13, 23 |
| 6 | Vanguard Institutional Extnd Mkt Idx Tr | 957.46K (0.94%) | -436.29K Decreased by -45.57% | Jul 31, 25 |
| 7 | Fidelity Extended Market Index | 495.70K (0.49%) | 4.85K Increased by +0.98% | Jul 31, 25 |
| 8 | abrdn World Healthcare | 476.25K (0.47%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 9 | BlackRock Extended Equity Market K | 232.59K (0.23%) | -99.00 Decreased by -0.04% | Sep 30, 24 |
| 10 | Extended Equity Market Fund K | 225.63K (0.22%) | -4.50K Decreased by -2.00% | Jun 30, 25 |
| 11 | iShares Micro-Cap ETF | 213.35K (0.21%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 12 | Fidelity Total Market Index | 160.00K (0.16%) | -341.00 Decreased by -0.21% | Jul 31, 25 |
| 13 | A4Investments SICAV SIF ACCI IlanaA2EURH | 150.00K (0.15%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 14 | Fidelity® Extended Market Index | 137.75K (0.14%) | -76.62K Decreased by -55.62% | Oct 31, 23 |
| 15 | Vifag 2002 SICAV | 130.00K (0.13%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 16 | Fidelity Series Total Market Index | 125.65K (0.12%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 17 | BlackRock Extended Mkt Composite | 116.40K (0.11%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 18 | Bridgeway Ultra-Small Company Market | 115.00K (0.11%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 19 | NT Ext Equity Mkt Idx Fd - NL | 110.82K (0.11%) | 28.04K Increased by +25.30% | Jun 30, 25 |
| 20 | Spartan Extended Market Index Pool F | 107.06K (0.11%) | 4.08K Increased by +3.81% | Jul 31, 25 |