| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BlackRock Inc | 49.86M (8.29%) | 1.22M Increased by +2.45% | Dec 31, 24 |
| 2 | RTW INVESTMENTS, LLC | 44.11M (7.34%) | 44.11M Increased by +100.00% | Sep 30, 24 |
| 3 | Vanguard Group Inc | 33.54M (5.58%) | 1.09M Increased by +3.25% | Dec 31, 24 |
| 4 | State Street Corporation | 31.60M (5.26%) | 5.98M Increased by +18.92% | Mar 31, 24 |
| 5 | RA Capital Management, LLC | 30.01M (4.99%) | -2.28M Decreased by -7.58% | Dec 31, 24 |
| 6 | Vivo Capital, LLC | 27.23M (4.53%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 7 | State Street Corp | 27.16M (4.52%) | -1.80M Decreased by -6.64% | Dec 31, 24 |
| 8 | HHG PLC | 27.08M (4.50%) | 4.52M Increased by +16.68% | Dec 31, 24 |
| 9 | Holocene Advisors, LP | 22.20M (3.69%) | 4.02M Increased by +18.13% | Dec 31, 24 |
| 10 | Adage Capital Partners Gp LLC | 21.80M (3.63%) | -7.08M Decreased by -32.45% | Dec 31, 24 |
| 11 | TCG Crossover Management, LLC | 17.39M (2.89%) | -5.98M Decreased by -34.41% | Mar 31, 24 |
| 12 | Farallon Capital Management, L.L.C. | 16.84M (2.80%) | 9.34M Increased by +55.48% | Jun 30, 24 |
| 13 | FMR Inc | 14.33M (2.38%) | -646.27K Decreased by -4.51% | Dec 31, 24 |
| 14 | Goldman Sachs Group Inc | 13.61M (2.26%) | -4.33M Decreased by -31.82% | Dec 31, 24 |
| 15 | Wellington Management Company LLP | 13.51M (2.25%) | 847.71K Increased by +6.27% | Dec 31, 24 |
| 16 | Geode Capital Management, LLC | 13.14M (2.19%) | 73.52K Increased by +0.56% | Dec 31, 24 |
| 17 | NEA Management Company, LLC | 12.78M (2.13%) | -10.00M Decreased by -78.27% | Mar 31, 24 |
| 18 | Morgan Stanley - Brokerage Accounts | 11.69M (1.94%) | 9.09M Increased by +77.79% | Dec 31, 24 |
| 19 | Woodline Partners LP | 11.59M (1.93%) | 4.55M Increased by +39.26% | Dec 31, 24 |
| 20 | Vestal Point Capital LP | 11.00M (1.83%) | 9.95M Increased by +90.45% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 18.07M (3.01%) | 15.92K Increased by +0.09% | Feb 28, 25 |
| 2 | iShares Russell 2000 ETF | 15.53M (2.58%) | -134.53K Decreased by -0.87% | Mar 31, 25 |
| 3 | SPDR® S&P Biotech ETF | 10.80M (1.80%) | -115.72K Decreased by -1.07% | Mar 31, 25 |
| 4 | Vanguard Institutional Extnd Mkt Idx Tr | 8.00M (1.33%) | 12.16K Increased by +0.15% | Feb 28, 25 |
| 5 | Eventide Healthcare & Life Sciences I | 7.07M (1.18%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 6 | Fidelity Small Cap Index | 5.84M (0.97%) | -109.30K Decreased by -1.87% | Jan 31, 25 |
| 7 | Fidelity Growth Compy Commingled Pl S | 5.52M (0.92%) | 8.77K Increased by +0.16% | Feb 28, 25 |
| 8 | Fidelity® Small Cap Index | 4.81M (0.80%) | 131.18K Increased by +2.73% | Oct 31, 23 |
| 9 | Fidelity Growth Compy Commingled Pl O | 4.29M (0.71%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 10 | iShares Biotechnology ETF | 3.82M (0.64%) | -42.53K Decreased by -1.11% | Mar 31, 25 |
| 11 | iShares Russell 2000 Growth ETF | 3.63M (0.60%) | -17.28K Decreased by -0.48% | Mar 31, 25 |
| 12 | State St Russell Sm/Mid Cp® Indx NL Cl C | 3.63M (0.60%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 13 | Fidelity Growth Company Fund | 3.43M (0.57%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 14 | Invesco Pharmaceuticals ETF | 3.03M (0.50%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 15 | Janus Henderson Global Life Sciences | 2.99M (0.50%) | 575.24K Increased by +19.21% | Dec 31, 24 |
| 16 | Janus Henderson Global Life Sciences D | 2.95M (0.49%) | -44.65K Decreased by -1.51% | Jan 31, 25 |
| 17 | Fidelity® Select Biotechnology | 2.95M (0.49%) | -257.60K Decreased by -8.74% | Nov 30, 23 |
| 18 | Fidelity Select Biotechnology | 2.90M (0.48%) | -1.38M Decreased by -47.68% | Dec 31, 24 |
| 19 | Fidelity Extended Market Index | 2.85M (0.47%) | -18.18K Decreased by -0.64% | Feb 28, 25 |
| 20 | Vanguard Russell 2000 ETF | 2.70M (0.45%) | 73.52K Increased by +2.72% | Feb 28, 25 |