| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 63.77M (11.90%) | 3.39M Increased by +5.32% | Dec 31, 25 |
| 2 | BlackRock Inc | 45.91M (8.57%) | -692.41K Decreased by -1.51% | Dec 31, 25 |
| 3 | RTW INVESTMENTS, LLC | 44.11M (8.23%) | 44.11M Increased by +100.00% | Sep 30, 24 |
| 4 | Vanguard Group Inc | 35.66M (6.66%) | 1.24M Increased by +3.47% | Dec 31, 25 |
| 5 | Deep Track Capital, LP | 32.51M (6.07%) | -8.59M Decreased by -26.41% | Dec 31, 25 |
| 6 | State Street Corporation | 31.60M (5.90%) | 5.98M Increased by +18.92% | Mar 31, 24 |
| 7 | Vivo Capital, LLC | 27.23M (5.08%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 8 | State Street Corp | 26.87M (5.02%) | 248.51K Increased by +0.92% | Dec 31, 25 |
| 9 | Soleus Capital Management, L.P. | 23.29M (4.35%) | 6.00M Increased by +25.76% | Dec 31, 25 |
| 10 | Holocene Advisors, LP | 22.20M (4.14%) | 4.02M Increased by +18.13% | Dec 31, 24 |
| 11 | Adage Capital Partners Gp LLC | 21.80M (4.07%) | -7.08M Decreased by -32.45% | Dec 31, 24 |
| 12 | ClearBridge Advisors, LLC | 19.62M (3.66%) | 5.38M Increased by +27.41% | Mar 31, 26 |
| 13 | HHG PLC | 18.89M (3.53%) | -8.19M Decreased by -43.35% | Mar 31, 25 |
| 14 | Eversept Partners, LP | 17.66M (3.30%) | 5.06M Increased by +28.66% | Dec 31, 25 |
| 15 | TCG Crossover Management, LLC | 17.39M (3.25%) | -5.98M Decreased by -34.41% | Mar 31, 24 |
| 16 | Farallon Capital Management, L.L.C. | 16.84M (3.14%) | 9.34M Increased by +55.48% | Jun 30, 24 |
| 17 | The Goldman Sachs Group Inc | 16.17M (3.02%) | -5.13M Decreased by -31.74% | Dec 31, 25 |
| 18 | Wellington Management Company LLP | 13.51M (2.52%) | 847.71K Increased by +6.27% | Dec 31, 24 |
| 19 | Geode Capital Management, LLC | 13.03M (2.43%) | -96.20K Decreased by -0.74% | Dec 31, 25 |
| 20 | NEA Management Company, LLC | 12.78M (2.38%) | -10.00M Decreased by -78.27% | Mar 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 20.05M (3.74%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 2 | State Street® SPDR® S&P® Biotech ETF | 18.57M (3.47%) | -131.80K Decreased by -0.71% | Apr 30, 26 |
| 3 | Vanguard US Total Market Shares ETF | 17.83M (3.33%) | 17.67K Increased by +0.10% | Sep 30, 24 |
| 4 | BioPharma Credit Ord | 14.12M (2.64%) | 14.12M Increased by +100.00% | Dec 31, 24 |
| 5 | iShares Russell 2000 ETF | 12.81M (2.39%) | 108.01K Increased by +0.84% | Apr 30, 26 |
| 6 | ClearBridge SMID Cap Growth | 10.17M (1.90%) | 10.17M Increased by +99.99% | Mar 31, 26 |
| 7 | Vanguard Explorer Inv | 10.17M (1.90%) | 1.39M Increased by +13.68% | Mar 31, 26 |
| 8 | SPDR® S&P Biotech ETF | 10.09M (1.88%) | 22.55K Increased by +0.22% | Aug 31, 25 |
| 9 | Eventide Healthcare & Life Sciences I | 7.07M (1.32%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 10 | Fidelity Select Biotechnology | 6.49M (1.21%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 11 | ClearBridge Small Cap Growth | 6.32M (1.18%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 12 | ClearBridge Small Cap Growth A | 6.32M (1.18%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 13 | Vanguard Institutional Extnd Mkt Idx Tr | 5.96M (1.11%) | 72.46K Increased by +1.22% | Mar 31, 26 |
| 14 | Fidelity Small Cap Index | 5.34M (1.00%) | 39.13K Increased by +0.73% | Feb 28, 26 |
| 15 | Fidelity® Small Cap Index | 4.81M (0.90%) | 131.18K Increased by +2.73% | Oct 31, 23 |
| 16 | Xtrackers MSCI World Swap ETF 1C | 4.66M (0.87%) | -29.36K Decreased by -0.63% | Dec 31, 25 |
| 17 | iShares Russell 2000 Growth ETF | 4.52M (0.84%) | 110.76K Increased by +2.45% | Apr 30, 26 |
| 18 | iShares Biotechnology ETF | 4.50M (0.84%) | 79.68K Increased by +1.77% | Apr 30, 26 |
| 19 | Fidelity Growth Compy Commingled Pl O | 4.29M (0.80%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 20 | State St Russell Sm/Mid Cp® Indx NL Cl C | 3.47M (0.65%) | 14.43K Increased by +0.42% | Apr 30, 25 |