| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 60.38M (11.23%) | 30.37M Increased by +50.30% | Mar 31, 25 |
| 2 | BlackRock Inc | 49.08M (9.13%) | -782.45K Decreased by -1.59% | Mar 31, 25 |
| 3 | RTW INVESTMENTS, LLC | 44.11M (8.20%) | 44.11M Increased by +100.00% | Sep 30, 24 |
| 4 | Deep Track Capital, LP | 38.18M (7.10%) | 34.16M Increased by +89.49% | Mar 31, 25 |
| 5 | Vanguard Group Inc | 34.15M (6.35%) | 608.03K Increased by +1.78% | Mar 31, 25 |
| 6 | State Street Corporation | 31.60M (5.88%) | 5.98M Increased by +18.92% | Mar 31, 24 |
| 7 | Vivo Capital, LLC | 27.23M (5.06%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 8 | State Street Corp | 23.91M (4.45%) | -3.25M Decreased by -13.58% | Mar 31, 25 |
| 9 | Holocene Advisors, LP | 22.20M (4.13%) | 4.02M Increased by +18.13% | Dec 31, 24 |
| 10 | Vestal Point Capital LP | 22.01M (4.09%) | 11.01M Increased by +50.01% | Mar 31, 25 |
| 11 | Adage Capital Partners Gp LLC | 21.80M (4.05%) | -7.08M Decreased by -32.45% | Dec 31, 24 |
| 12 | HHG PLC | 18.89M (3.51%) | -8.19M Decreased by -43.35% | Mar 31, 25 |
| 13 | TCG Crossover Management, LLC | 17.39M (3.23%) | -5.98M Decreased by -34.41% | Mar 31, 24 |
| 14 | Farallon Capital Management, L.L.C. | 16.84M (3.13%) | 9.34M Increased by +55.48% | Jun 30, 24 |
| 15 | Geode Capital Management, LLC | 13.57M (2.52%) | 426.08K Increased by +3.14% | Mar 31, 25 |
| 16 | Wellington Management Company LLP | 13.51M (2.51%) | 847.71K Increased by +6.27% | Dec 31, 24 |
| 17 | NEA Management Company, LLC | 12.78M (2.38%) | -10.00M Decreased by -78.27% | Mar 31, 24 |
| 18 | FMR Inc | 12.37M (2.30%) | -1.97M Decreased by -15.91% | Mar 31, 25 |
| 19 | Morgan Stanley - Brokerage Accounts | 11.53M (2.14%) | -153.10K Decreased by -1.33% | Mar 31, 25 |
| 20 | Millennium Management LLC | 10.81M (2.01%) | 3.77M Increased by +34.90% | Mar 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 19.66M (3.66%) | 0.00 Increased by 0.00% | May 31, 25 |
| 2 | Vanguard US Total Market Shares ETF | 17.83M (3.31%) | 17.67K Increased by +0.10% | Sep 30, 24 |
| 3 | iShares Russell 2000 ETF | 15.12M (2.81%) | 105.00K Increased by +0.69% | Jun 30, 25 |
| 4 | BioPharma Credit Ord | 14.12M (2.63%) | 14.12M Increased by +100.00% | Dec 31, 24 |
| 5 | SPDR® S&P Biotech ETF | 10.11M (1.88%) | -165.38K Decreased by -1.64% | Jun 30, 25 |
| 6 | Vanguard Institutional Extnd Mkt Idx Tr | 8.29M (1.54%) | 66.24K Increased by +0.80% | May 31, 25 |
| 7 | Eventide Healthcare & Life Sciences I | 7.07M (1.31%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 8 | Fidelity Small Cap Index | 6.01M (1.12%) | 103.04K Increased by +1.71% | Apr 30, 25 |
| 9 | Vanguard Explorer Inv | 5.80M (1.08%) | 5.38M Increased by +92.85% | Mar 31, 25 |
| 10 | iShares Russell 2000 Growth ETF | 5.32M (0.99%) | 13.11K Increased by +0.25% | Jun 30, 25 |
| 11 | Fidelity® Small Cap Index | 4.81M (0.89%) | 131.18K Increased by +2.73% | Oct 31, 23 |
| 12 | abrdn Healthcare Investors | 4.63M (0.86%) | 895.96K Increased by +19.36% | Jun 30, 25 |
| 13 | Fidelity Growth Compy Commingled Pl O | 4.29M (0.80%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 14 | ClearBridge Small Cap Growth A | 3.77M (0.70%) | 1.68M Increased by +44.69% | Jun 30, 25 |
| 15 | iShares Biotechnology ETF | 3.73M (0.69%) | -13.45K Decreased by -0.36% | Jun 30, 25 |
| 16 | State St Russell Sm/Mid Cp® Indx NL Cl C | 3.47M (0.65%) | 14.43K Increased by +0.42% | Apr 30, 25 |
| 17 | State St Russell Sm/Mid Cp® Indx SL Cl I | 3.45M (0.64%) | -24.20K Decreased by -0.70% | Jun 30, 25 |
| 18 | Fidelity Growth Company Fund | 3.43M (0.64%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 19 | Xtrackers MSCI World Swap ETF 1C | 3.33M (0.62%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 20 | Fidelity Growth Compy Commingled Pl S | 3.28M (0.61%) | -2.23M Decreased by -68.05% | Apr 30, 25 |