| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BlackRock Inc | 46.55M (8.35%) | 5.14M Increased by +11.04% | Jun 30, 24 |
| 2 | RTW INVESTMENTS, LLC | 44.11M (7.91%) | 44.11M Increased by +100.00% | Sep 30, 24 |
| 3 | Vanguard Group Inc | 32.45M (5.82%) | 516.61K Increased by +1.59% | Sep 30, 24 |
| 4 | RA Capital Management, LLC | 32.29M (5.79%) | -13.92M Decreased by -43.10% | Sep 30, 24 |
| 5 | State Street Corporation | 31.60M (5.67%) | 5.98M Increased by +18.92% | Mar 31, 24 |
| 6 | State Street Corp | 28.96M (5.19%) | 6.41M Increased by +22.14% | Sep 30, 24 |
| 7 | Adage Capital Partners Gp LLC | 28.88M (5.18%) | 9.15M Increased by +31.69% | Sep 30, 24 |
| 8 | Vivo Capital, LLC | 27.23M (4.88%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 9 | HHG PLC | 22.57M (4.05%) | 13.16M Increased by +58.34% | Sep 30, 24 |
| 10 | Darwin Global Management, Ltd. | 22.04M (3.95%) | -1.88M Decreased by -8.52% | Sep 30, 24 |
| 11 | Holocene Advisors, LP | 18.17M (3.26%) | 18.17M Increased by +100.00% | Sep 30, 24 |
| 12 | Goldman Sachs Group Inc | 17.94M (3.22%) | 6.64M Increased by +37.03% | Sep 30, 24 |
| 13 | TCG Crossover Management, LLC | 17.39M (3.12%) | -5.98M Decreased by -34.41% | Mar 31, 24 |
| 14 | Farallon Capital Management, L.L.C. | 16.84M (3.02%) | 9.34M Increased by +55.48% | Jun 30, 24 |
| 15 | FMR Inc | 14.98M (2.69%) | -376.72K Decreased by -2.51% | Sep 30, 24 |
| 16 | Geode Capital Management, LLC | 13.07M (2.34%) | 231.18K Increased by +1.77% | Sep 30, 24 |
| 17 | NEA Management Company, LLC | 12.78M (2.29%) | -10.00M Decreased by -78.27% | Mar 31, 24 |
| 18 | Wellington Management Company LLP | 12.66M (2.27%) | 570.58K Increased by +4.51% | Sep 30, 24 |
| 19 | Morgan Stanley - Brokerage Accounts | 10.56M (1.89%) | 9.20M Increased by +87.08% | Dec 31, 23 |
| 20 | MPM Oncology Impact Management LP | 10.48M (1.88%) | -239.94K Decreased by -2.29% | Mar 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 17.73M (3.18%) | -101.33K Decreased by -0.57% | Oct 31, 24 |
| 2 | iShares Russell 2000 ETF | 16.16M (2.90%) | -33.77K Decreased by -0.21% | Nov 27, 24 |
| 3 | SPDR® S&P Biotech ETF | 15.60M (2.80%) | -473.85K Decreased by -3.04% | Nov 27, 24 |
| 4 | Vanguard Institutional Extnd Mkt Idx Tr | 7.78M (1.40%) | -29.38K Decreased by -0.38% | Oct 31, 24 |
| 5 | Eventide Healthcare & Life Sciences I | 6.36M (1.14%) | 6.36M Increased by +100.00% | Jun 30, 24 |
| 6 | Fidelity Small Cap Index | 5.90M (1.06%) | -144.97K Decreased by -2.46% | Aug 31, 24 |
| 7 | Fidelity Select Biotechnology | 5.81M (1.04%) | -456.70K Decreased by -7.86% | Sep 30, 24 |
| 8 | Fidelity® Small Cap Index | 4.81M (0.86%) | 131.18K Increased by +2.73% | Oct 31, 23 |
| 9 | Fidelity Growth Compy Commingled Pl S | 4.31M (0.77%) | 25.11K Increased by +0.58% | Sep 30, 24 |
| 10 | Fidelity Growth Compy Commingled Pl O | 4.29M (0.77%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 11 | iShares Biotechnology ETF | 3.80M (0.68%) | 3.86K Increased by +0.10% | Nov 27, 24 |
| 12 | State St Russell Sm/Mid Cp® Indx NL Cl C | 3.68M (0.66%) | -119.70K Decreased by -3.25% | Oct 31, 24 |
| 13 | iShares Russell 2000 Growth ETF | 3.66M (0.66%) | 0.00 Increased by 0.00% | Nov 27, 24 |
| 14 | Fidelity Extended Market Index | 3.05M (0.55%) | -90.98K Decreased by -2.98% | Sep 30, 24 |
| 15 | Fidelity® Select Biotechnology | 2.95M (0.53%) | -257.60K Decreased by -8.74% | Nov 30, 23 |
| 16 | Biotech Growth Ord | 2.85M (0.51%) | 2.85M Increased by +100.00% | Jun 30, 24 |
| 17 | Fidelity Growth Company Fund | 2.65M (0.48%) | -5.64K Decreased by -0.21% | Sep 30, 24 |
| 18 | Vanguard Russell 2000 ETF | 2.65M (0.48%) | -16.51K Decreased by -0.62% | Oct 31, 24 |
| 19 | Schwab US Small-Cap ETF™ | 2.54M (0.46%) | 1.44K Increased by +0.06% | Nov 28, 24 |
| 20 | Fidelity® Extended Market Index | 2.47M (0.44%) | 0.00 Increased by 0.00% | Nov 30, 23 |