| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 63.77M (11.90%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 2 | BlackRock Inc | 47.32M (8.83%) | 1.41M Increased by +2.97% | Mar 31, 26 |
| 3 | RTW INVESTMENTS, LLC | 44.11M (8.23%) | 44.11M Increased by +100.00% | Sep 30, 24 |
| 4 | Soleus Capital Management, L.P. | 41.51M (7.75%) | 18.22M Increased by +43.89% | Mar 31, 26 |
| 5 | Vanguard Group Inc | 35.66M (6.66%) | 1.24M Increased by +3.47% | Dec 31, 25 |
| 6 | Deep Track Capital, LP | 31.72M (5.92%) | -790.99K Decreased by -2.49% | Mar 31, 26 |
| 7 | State Street Corporation | 31.60M (5.90%) | 5.98M Increased by +18.92% | Mar 31, 24 |
| 8 | State Street Corp | 30.50M (5.69%) | 3.63M Increased by +11.90% | Mar 31, 26 |
| 9 | Vanguard Capital Management, LLC | 26.67M (4.98%) | 26.67M Increased by +100.00% | Mar 31, 26 |
| 10 | Holocene Advisors, LP | 22.20M (4.14%) | 4.02M Increased by +18.13% | Dec 31, 24 |
| 11 | Adage Capital Partners Gp LLC | 21.80M (4.07%) | -7.08M Decreased by -32.45% | Dec 31, 24 |
| 12 | Citadel Advisors Llc | 21.58M (4.03%) | 11.65M Increased by +54.00% | Mar 31, 26 |
| 13 | Point72 Asset Management, L.P. | 20.46M (3.82%) | 20.46M Increased by +100.00% | Mar 31, 26 |
| 14 | ClearBridge Advisors, LLC | 19.62M (3.66%) | 5.38M Increased by +27.41% | Mar 31, 26 |
| 15 | HHG PLC | 18.89M (3.53%) | -8.19M Decreased by -43.35% | Mar 31, 25 |
| 16 | Eversept Partners, LP | 18.83M (3.52%) | 1.17M Increased by +6.24% | Mar 31, 26 |
| 17 | TCG Crossover Management, LLC | 17.39M (3.25%) | -5.98M Decreased by -34.41% | Mar 31, 24 |
| 18 | Farallon Capital Management, L.L.C. | 16.84M (3.14%) | 9.34M Increased by +55.48% | Jun 30, 24 |
| 19 | Geode Capital Management, LLC | 13.67M (2.55%) | 643.45K Increased by +4.71% | Mar 31, 26 |
| 20 | Wellington Management Company LLP | 13.51M (2.52%) | 847.71K Increased by +6.27% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 20.05M (3.74%) | 0.00 Increased by 0.00% | Apr 30, 26 |
| 2 | State Street® SPDR® S&P® Biotech ETF | 18.39M (3.43%) | -113.07K Decreased by -0.61% | May 31, 26 |
| 3 | Vanguard US Total Market Shares ETF | 17.83M (3.33%) | 17.67K Increased by +0.10% | Sep 30, 24 |
| 4 | BioPharma Credit Ord | 14.12M (2.64%) | 14.12M Increased by +100.00% | Dec 31, 24 |
| 5 | iShares Russell 2000 ETF | 12.93M (2.41%) | 119.50K Increased by +0.92% | May 29, 26 |
| 6 | ClearBridge SMID Cap Growth | 10.17M (1.90%) | 0.00 Increased by 0.00% | Apr 30, 26 |
| 7 | Vanguard Explorer Inv | 10.17M (1.90%) | 1.39M Increased by +13.68% | Mar 31, 26 |
| 8 | SPDR® S&P Biotech ETF | 10.09M (1.88%) | 22.55K Increased by +0.22% | Aug 31, 25 |
| 9 | Eventide Healthcare & Life Sciences I | 7.07M (1.32%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 10 | ClearBridge Small Cap Growth | 6.32M (1.18%) | 0.00 Increased by 0.00% | Apr 30, 26 |
| 11 | ClearBridge Small Cap Growth A | 6.32M (1.18%) | 0.00 Increased by 0.00% | Apr 30, 26 |
| 12 | Vanguard Institutional Extnd Mkt Idx Tr | 6.04M (1.13%) | 87.72K Increased by +1.45% | Apr 30, 26 |
| 13 | Fidelity Select Biotechnology | 5.45M (1.02%) | -1.04M Decreased by -19.08% | Apr 30, 26 |
| 14 | Fidelity Small Cap Index | 5.35M (1.00%) | 5.65K Increased by +0.11% | Mar 31, 26 |
| 15 | Fidelity® Small Cap Index | 4.81M (0.90%) | 131.18K Increased by +2.73% | Oct 31, 23 |
| 16 | Xtrackers MSCI World Swap ETF 1C | 4.66M (0.87%) | -29.36K Decreased by -0.63% | Dec 31, 25 |
| 17 | iShares Russell 2000 Growth ETF | 4.47M (0.83%) | -29.11K Decreased by -0.65% | May 29, 26 |
| 18 | iShares Biotechnology ETF | 4.46M (0.83%) | 85.43K Increased by +1.91% | May 29, 26 |
| 19 | Fidelity Growth Compy Commingled Pl O | 4.29M (0.80%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 20 | State St Russell Sm/Mid Cp® Indx NL Cl C | 3.47M (0.65%) | 14.43K Increased by +0.42% | Apr 30, 25 |