| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 60.38M (11.31%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 2 | BlackRock Inc | 50.02M (9.37%) | 948.18K Increased by +1.90% | Jun 30, 25 |
| 3 | RTW INVESTMENTS, LLC | 44.11M (8.26%) | 44.11M Increased by +100.00% | Sep 30, 24 |
| 4 | Deep Track Capital, LP | 43.00M (8.05%) | 4.82M Increased by +11.22% | Jun 30, 25 |
| 5 | Vanguard Group Inc | 35.61M (6.67%) | 1.47M Increased by +4.12% | Jun 30, 25 |
| 6 | State Street Corporation | 31.60M (5.92%) | 5.98M Increased by +18.92% | Mar 31, 24 |
| 7 | Vivo Capital, LLC | 27.23M (5.10%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 8 | Vestal Point Capital LP | 23.77M (4.45%) | 1.77M Increased by +7.44% | Jun 30, 25 |
| 9 | State Street Corp | 23.63M (4.42%) | -279.92K Decreased by -1.18% | Jun 30, 25 |
| 10 | Holocene Advisors, LP | 22.20M (4.16%) | 4.02M Increased by +18.13% | Dec 31, 24 |
| 11 | Adage Capital Partners Gp LLC | 21.80M (4.08%) | -7.08M Decreased by -32.45% | Dec 31, 24 |
| 12 | HHG PLC | 18.89M (3.54%) | -8.19M Decreased by -43.35% | Mar 31, 25 |
| 13 | TCG Crossover Management, LLC | 17.39M (3.26%) | -5.98M Decreased by -34.41% | Mar 31, 24 |
| 14 | Farallon Capital Management, L.L.C. | 16.84M (3.15%) | 9.34M Increased by +55.48% | Jun 30, 24 |
| 15 | Soleus Capital Management, L.P. | 16.14M (3.02%) | 13.74M Increased by +85.13% | Jun 30, 25 |
| 16 | ClearBridge Advisors, LLC | 14.38M (2.69%) | 5.69M Increased by +39.57% | Jun 30, 25 |
| 17 | Geode Capital Management, LLC | 14.15M (2.65%) | 584.44K Increased by +4.13% | Jun 30, 25 |
| 18 | Wellington Management Company LLP | 13.51M (2.53%) | 847.71K Increased by +6.27% | Dec 31, 24 |
| 19 | Morgan Stanley - Brokerage Accounts | 13.30M (2.49%) | 1.76M Increased by +13.25% | Jun 30, 25 |
| 20 | NEA Management Company, LLC | 12.78M (2.39%) | -10.00M Decreased by -78.27% | Mar 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 19.23M (3.60%) | -426.49K Decreased by -2.22% | Jul 31, 25 |
| 2 | Vanguard US Total Market Shares ETF | 17.83M (3.34%) | 17.67K Increased by +0.10% | Sep 30, 24 |
| 3 | iShares Russell 2000 ETF | 14.46M (2.71%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 4 | BioPharma Credit Ord | 14.12M (2.64%) | 14.12M Increased by +100.00% | Dec 31, 24 |
| 5 | SPDR® S&P Biotech ETF | 10.09M (1.89%) | 22.55K Increased by +0.22% | Aug 31, 25 |
| 6 | Fidelity Select Biotechnology | 9.08M (1.70%) | 4.38M Increased by +48.26% | Jul 31, 25 |
| 7 | Vanguard Explorer Inv | 8.92M (1.67%) | 3.12M Increased by +35.02% | Jun 30, 25 |
| 8 | Eventide Healthcare & Life Sciences I | 7.07M (1.32%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 9 | Fidelity Small Cap Index | 6.10M (1.14%) | 90.62K Increased by +1.49% | Jun 30, 25 |
| 10 | Vanguard Institutional Extnd Mkt Idx Tr | 6.10M (1.14%) | -2.66M Decreased by -43.57% | Jul 31, 25 |
| 11 | iShares Russell 2000 Growth ETF | 5.28M (0.99%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 12 | Fidelity® Small Cap Index | 4.81M (0.90%) | 131.18K Increased by +2.73% | Oct 31, 23 |
| 13 | Fidelity Growth Compy Commingled Pl O | 4.29M (0.80%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 14 | ClearBridge Small Cap Growth | 3.77M (0.71%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 15 | ClearBridge Small Cap Growth A | 3.77M (0.71%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 16 | abrdn Healthcare Investors | 3.63M (0.68%) | -998.27K Decreased by -27.50% | Aug 31, 25 |
| 17 | iShares Biotechnology ETF | 3.61M (0.68%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 18 | State St Russell Sm/Mid Cp® Indx NL Cl C | 3.47M (0.65%) | 14.43K Increased by +0.42% | Apr 30, 25 |
| 19 | State St Russell Sm/Mid Cp® Indx SL Cl I | 3.45M (0.65%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 20 | Fidelity Growth Company Fund | 3.43M (0.64%) | 0.00 Increased by 0.00% | Mar 31, 25 |