| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 10.23M (41.38%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 2 | RTW INVESTMENTS, LLC | 5.85M (23.65%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 3 | TCG Crossover Management, LLC | 5.25M (21.24%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 4 | Suvretta Capital Management, LLC | 5.07M (20.50%) | 1.73M Increased by +34.12% | Mar 31, 25 |
| 5 | Nantahala Capital Management, LLC | 4.82M (19.51%) | 42.98K Increased by +0.89% | Mar 31, 25 |
| 6 | BlackRock Inc | 4.71M (19.05%) | -458.73K Decreased by -9.74% | Mar 31, 25 |
| 7 | Vanguard Group Inc | 3.22M (13.03%) | -29.23K Decreased by -0.91% | Mar 31, 25 |
| 8 | Adage Capital Partners Gp LLC | 3.00M (12.13%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 9 | COWEN AND COMPANY, LLC | 2.96M (11.99%) | -749.81K Decreased by -25.30% | Jun 30, 24 |
| 10 | TRV GP IV, LLC | 2.34M (9.48%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 11 | FMR Inc | 1.72M (6.97%) | -3.61M Decreased by -209.16% | Sep 30, 24 |
| 12 | Morgan Stanley - Brokerage Accounts | 1.53M (6.20%) | 1.18M Increased by +77.11% | Dec 31, 24 |
| 13 | MPM Oncology Impact Management LP | 1.44M (5.84%) | 307.74K Increased by +21.30% | Jun 30, 24 |
| 14 | Jefferies Financial Group Inc | 1.43M (5.80%) | 281.59K Increased by +19.65% | Jun 30, 24 |
| 15 | Dimensional Fund Advisors, Inc. | 1.41M (5.69%) | -11.64K Decreased by -0.83% | Mar 31, 25 |
| 16 | Geode Capital Management, LLC | 1.29M (5.24%) | -26.35K Decreased by -2.04% | Dec 31, 24 |
| 17 | State Street Corp | 1.25M (5.07%) | 7.12K Increased by +0.57% | Mar 31, 25 |
| 18 | Logos Global Management LP | 1.20M (4.85%) | 1.20M Increased by +100.00% | Dec 31, 23 |
| 19 | Vestal Point Capital LP | 1.16M (4.69%) | 465.00K Increased by +40.09% | Jun 30, 24 |
| 20 | BRAIDWELL LP | 1.07M (4.32%) | 1.07M Increased by +100.00% | Sep 30, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 1.85M (7.49%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 2 | Vanguard US Total Market Shares ETF | 1.85M (7.49%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | Fidelity Growth Compy Commingled Pl O | 1.81M (7.33%) | 0.00 Increased by 0.00% | May 31, 24 |
| 4 | Fidelity® Select Biotechnology | 1.56M (6.30%) | -136.10K Decreased by -8.73% | Nov 30, 23 |
| 5 | iShares Russell 2000 ETF | 1.38M (5.58%) | 233.00 Increased by +0.02% | Apr 30, 25 |
| 6 | Fidelity Select Biotechnology | 1.26M (5.08%) | 0.00 Increased by 0.00% | May 31, 24 |
| 7 | Fidelity® Growth Company | 869.67K (3.52%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 8 | Select Pharmaceuticals Port | 762.00K (3.08%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 9 | Fidelity Select Pharmaceuticals Port | 683.60K (2.77%) | 0.00 Increased by 0.00% | May 31, 24 |
| 10 | Fidelity Small Cap Index | 636.35K (2.57%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 11 | Vanguard Institutional Extnd Mkt Idx Tr | 618.20K (2.50%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 12 | Fidelity Growth Compy Commingled Pl S | 494.64K (2.00%) | -295.57K Decreased by -59.75% | Nov 30, 24 |
| 13 | Fidelity® Growth Company K6 | 471.79K (1.91%) | -51.29K Decreased by -10.87% | Nov 30, 23 |
| 14 | Simplify Propel Opportunities ETF | 465.00K (1.88%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 15 | SPDR® S&P Pharmaceuticals ETF | 436.70K (1.77%) | 0.00 Increased by 0.00% | Nov 30, 24 |
| 16 | Invesco Dorsey Wright SmallCap Momt ETF | 380.63K (1.54%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 17 | State St Russell Sm/Mid Cp® Indx NL Cl C | 368.38K (1.49%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 18 | State St Russell Sm/Mid Cp® Indx SL Cl I | 368.38K (1.49%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 19 | Fidelity® Series Growth Company | 356.20K (1.44%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 20 | iShares Biotechnology ETF | 317.82K (1.29%) | 0.00 Increased by 0.00% | Nov 30, 24 |