| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 10.23M (70.13%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 2 | RTW INVESTMENTS, LLC | 5.85M (40.08%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 3 | TCG Crossover Management, LLC | 5.25M (35.99%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 4 | Suvretta Capital Management, LLC | 5.07M (34.74%) | 1.73M Increased by +34.12% | Mar 31, 25 |
| 5 | Nantahala Capital Management, LLC | 4.82M (33.06%) | 42.98K Increased by +0.89% | Mar 31, 25 |
| 6 | BlackRock Inc | 4.71M (32.30%) | -458.73K Decreased by -9.74% | Mar 31, 25 |
| 7 | Vanguard Group Inc | 3.15M (21.57%) | -73.94K Decreased by -2.35% | Jun 30, 25 |
| 8 | Adage Capital Partners Gp LLC | 3.00M (20.57%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 9 | COWEN AND COMPANY, LLC | 2.96M (20.32%) | -749.81K Decreased by -25.30% | Jun 30, 24 |
| 10 | TRV GP IV, LLC | 2.34M (16.06%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 11 | FMR Inc | 1.72M (11.82%) | -3.61M Decreased by -209.16% | Sep 30, 24 |
| 12 | Morgan Stanley - Brokerage Accounts | 1.53M (10.50%) | 1.18M Increased by +77.11% | Dec 31, 24 |
| 13 | MPM Oncology Impact Management LP | 1.44M (9.91%) | 307.74K Increased by +21.30% | Jun 30, 24 |
| 14 | Jefferies Financial Group Inc | 1.43M (9.83%) | 281.59K Increased by +19.65% | Jun 30, 24 |
| 15 | Dimensional Fund Advisors, Inc. | 1.37M (9.41%) | -34.41K Decreased by -2.51% | Jun 30, 25 |
| 16 | State Street Corp | 1.25M (8.59%) | 7.12K Increased by +0.57% | Mar 31, 25 |
| 17 | Geode Capital Management, LLC | 1.23M (8.44%) | -63.14K Decreased by -5.13% | Mar 31, 25 |
| 18 | Logos Global Management LP | 1.20M (8.23%) | 1.20M Increased by +100.00% | Dec 31, 23 |
| 19 | D. E. Shaw & Co LP | 1.18M (8.07%) | 596.05K Increased by +50.65% | Jun 30, 25 |
| 20 | Vestal Point Capital LP | 1.16M (7.95%) | 465.00K Increased by +40.09% | Jun 30, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard US Total Market Shares ETF | 1.85M (12.70%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 1.81M (12.42%) | -40.15K Decreased by -2.22% | Jul 31, 25 |
| 3 | Fidelity Growth Compy Commingled Pl O | 1.81M (12.42%) | 0.00 Increased by 0.00% | May 31, 24 |
| 4 | Fidelity® Select Biotechnology | 1.56M (10.68%) | -136.10K Decreased by -8.73% | Nov 30, 23 |
| 5 | iShares Russell 2000 ETF | 1.29M (8.82%) | -24.46K Decreased by -1.90% | Jul 31, 25 |
| 6 | Fidelity Select Biotechnology | 1.26M (8.60%) | 0.00 Increased by 0.00% | May 31, 24 |
| 7 | Fidelity® Growth Company | 869.67K (5.96%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 8 | Select Pharmaceuticals Port | 762.00K (5.22%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 9 | Fidelity Select Pharmaceuticals Port | 683.60K (4.69%) | 0.00 Increased by 0.00% | May 31, 24 |
| 10 | Fidelity Small Cap Index | 548.50K (3.76%) | -20.65K Decreased by -3.76% | May 31, 25 |
| 11 | Fidelity Growth Compy Commingled Pl S | 494.64K (3.39%) | -295.57K Decreased by -59.75% | Nov 30, 24 |
| 12 | Fidelity® Growth Company K6 | 471.79K (3.23%) | -51.29K Decreased by -10.87% | Nov 30, 23 |
| 13 | Simplify Propel Opportunities ETF | 465.00K (3.19%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 14 | Vanguard Institutional Extnd Mkt Idx Tr | 459.61K (3.15%) | -200.05K Decreased by -43.53% | Jul 31, 25 |
| 15 | SPDR® S&P Pharmaceuticals ETF | 436.70K (2.99%) | 0.00 Increased by 0.00% | Nov 30, 24 |
| 16 | iShares Russell 2000 Value ETF | 424.31K (2.91%) | 315.00 Increased by +0.07% | Jul 31, 25 |
| 17 | State St Russell Sm/Mid Cp® Indx NL Cl C | 368.38K (2.53%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 18 | State St Russell Sm/Mid Cp® Indx SL Cl I | 368.38K (2.53%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 19 | Invesco Dorsey Wright SmallCap Momt ETF | 361.52K (2.48%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 20 | Fidelity® Series Growth Company | 356.20K (2.44%) | 0.00 Increased by 0.00% | Nov 30, 23 |