| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 5.65M (14.56%) | 1.09M Increased by +19.28% | Dec 31, 25 |
| 2 | HHG PLC | 4.64M (11.94%) | 2.88M Increased by +62.18% | Dec 31, 25 |
| 3 | Bvf Inc | 4.63M (11.92%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 4 | The Goldman Sachs Group Inc | 4.30M (11.08%) | 174.49K Increased by +4.06% | Dec 31, 25 |
| 5 | Goldman Sachs Group Inc | 4.16M (10.71%) | -9.13K Decreased by -0.22% | Jun 30, 25 |
| 6 | BlackRock Inc | 4.06M (10.47%) | 195.75K Increased by +4.82% | Dec 31, 25 |
| 7 | Novo A/S | 3.65M (9.40%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 8 | Vanguard Group Inc | 3.09M (7.96%) | 518.40K Increased by +16.76% | Dec 31, 25 |
| 9 | Viking Global Investors LP | 2.93M (7.56%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 10 | State Street Corp | 2.69M (6.92%) | 1.79M Increased by +66.39% | Dec 31, 25 |
| 11 | State Street Corporation | 2.18M (5.61%) | 654.24K Increased by +30.04% | Mar 31, 24 |
| 12 | Armistice Capital, LLC | 1.94M (4.98%) | 840.00K Increased by +43.39% | Dec 31, 25 |
| 13 | Federated Hermes Inc | 1.61M (4.14%) | 14.65K Increased by +0.91% | Dec 31, 25 |
| 14 | Point72 Asset Management, L.P. | 1.54M (3.96%) | 1.54M Increased by +100.00% | Dec 31, 25 |
| 15 | Trails Edge Capital Partners, LP | 1.30M (3.35%) | 1.30M Increased by +100.00% | Mar 31, 26 |
| 16 | Adage Capital Partners Gp LLC | 1.24M (3.18%) | 1.06M Increased by +85.83% | Dec 31, 25 |
| 17 | BRAIDWELL LP | 1.23M (3.16%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 18 | Casdin Capital, LLC | 1.15M (2.96%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 19 | Millennium Management LLC | 1.15M (2.96%) | -334.32K Decreased by -29.09% | Sep 30, 25 |
| 20 | JPMorgan Chase & Co | 1.03M (2.64%) | 139.01K Increased by +13.54% | Sep 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 1.71M (4.39%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 2 | Vanguard US Total Market Shares ETF | 1.54M (3.96%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | State Street® SPDR® S&P® Biotech ETF | 1.50M (3.86%) | -14.80K Decreased by -0.99% | Apr 30, 26 |
| 4 | iShares Russell 2000 ETF | 1.03M (2.65%) | 8.65K Increased by +0.84% | Apr 30, 26 |
| 5 | SPDR® S&P Biotech ETF | 990.08K (2.55%) | -30.06K Decreased by -3.04% | Nov 27, 24 |
| 6 | Janus Henderson Gbl Life Sciences Divers | 851.19K (2.19%) | 851.19K Increased by +100.00% | Sep 30, 25 |
| 7 | Janus Henderson Global Life Sciences | 843.75K (2.17%) | 1.23K Increased by +0.15% | Mar 31, 26 |
| 8 | Janus Henderson Global Life Sciences D | 840.16K (2.16%) | -2.36K Decreased by -0.28% | Jan 31, 26 |
| 9 | Polar Capital Healthcare Opports Inc | 790.16K (2.03%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 10 | Janus Global Life Science AUSD | 782.98K (2.02%) | 38.58K Increased by +4.93% | Mar 31, 26 |
| 11 | Janus Henderson Glb Life Scn I2 USD | 782.98K (2.02%) | -12.20K Decreased by -1.56% | Mar 31, 26 |
| 12 | Polar Capital Biotech S Inc | 750.00K (1.93%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 13 | Janus Selection Global Life Science AUSD | 744.60K (1.92%) | -46.09K Decreased by -6.19% | Jun 30, 24 |
| 14 | Janus Henderson Hrzn Biotec E2 USD | 727.25K (1.87%) | 78.47K Increased by +10.79% | Mar 31, 26 |
| 15 | Federated Hermes MDT SCC Institutional | 702.45K (1.81%) | -49.45K Decreased by -7.04% | Mar 31, 26 |
| 16 | Federated Hermes MDT Small Cap Core IS | 702.45K (1.81%) | -49.45K Decreased by -7.04% | Mar 31, 26 |
| 17 | Fidelity Growth Compy Commingled Pl O | 469.24K (1.21%) | 521.00 Increased by +0.11% | Jun 30, 24 |
| 18 | Vanguard Institutional Extnd Mkt Idx Tr | 441.99K (1.14%) | -35.65K Decreased by -8.06% | Mar 31, 26 |
| 19 | Eventide Healthcare & Life Sciences I | 422.86K (1.09%) | -458.30K Decreased by -108.38% | Sep 30, 24 |
| 20 | Nuveen Quant Small Cap Equity R6 | 396.50K (1.02%) | 396.50K Increased by +100.00% | Feb 28, 26 |