| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BlackRock Inc | 4.92M (14.34%) | 52.53K Increased by +1.07% | Dec 31, 24 |
| 2 | RA Capital Management, LLC | 4.56M (13.30%) | -535.00K Decreased by -11.72% | Dec 31, 24 |
| 3 | Goldman Sachs Group Inc | 4.27M (12.46%) | 683.94K Increased by +16.00% | Dec 31, 24 |
| 4 | VR Adviser, LLC | 2.95M (8.61%) | -1.45M Decreased by -49.03% | Dec 31, 24 |
| 5 | Viking Global Investors LP | 2.93M (8.55%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 6 | Vanguard Group Inc | 2.86M (8.34%) | 92.79K Increased by +3.24% | Dec 31, 24 |
| 7 | Bvf Inc | 2.67M (7.78%) | -4.71M Decreased by -176.44% | Dec 31, 24 |
| 8 | HHG PLC | 2.25M (6.56%) | -884.85K Decreased by -39.29% | Dec 31, 24 |
| 9 | State Street Corporation | 2.18M (6.35%) | 654.24K Increased by +30.04% | Mar 31, 24 |
| 10 | Morgan Stanley - Brokerage Accounts | 1.86M (5.43%) | 160.72K Increased by +8.63% | Dec 31, 24 |
| 11 | Novo A/S | 1.50M (4.37%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 12 | Millennium Management LLC | 1.42M (4.14%) | 1.34M Increased by +94.14% | Dec 31, 24 |
| 13 | BRAIDWELL LP | 1.23M (3.57%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 14 | Redmile Group, LLC | 1.20M (3.49%) | -65.18K Decreased by -5.45% | Dec 31, 24 |
| 15 | Casdin Capital, LLC | 1.15M (3.35%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 16 | State Street Corp | 1.11M (3.24%) | -1.00M Decreased by -90.21% | Dec 31, 24 |
| 17 | FMR Inc | 1.02M (2.96%) | 47.34K Increased by +4.66% | Jun 30, 24 |
| 18 | Geode Capital Management, LLC | 1.01M (2.95%) | -24.38K Decreased by -2.41% | Dec 31, 24 |
| 19 | Eventide Asset Management, LLC | 881.16K (2.57%) | 105.04K Increased by +11.92% | Jun 30, 24 |
| 20 | Polar Capital Holdings PLC | 838.49K (2.44%) | -906.37K Decreased by -108.09% | Sep 30, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 1.54M (4.48%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 2 | iShares Russell 2000 ETF | 1.23M (3.57%) | -10.62K Decreased by -0.87% | Mar 31, 25 |
| 3 | SPDR® S&P Biotech ETF | 990.08K (2.89%) | -30.06K Decreased by -3.04% | Nov 27, 24 |
| 4 | Janus Henderson Global Life Sciences | 902.96K (2.63%) | -113.28K Decreased by -12.55% | Dec 31, 24 |
| 5 | Janus Henderson Global Life Sciences D | 887.81K (2.59%) | -15.15K Decreased by -1.71% | Jan 31, 25 |
| 6 | Polar Capital Healthcare Opports Inc | 790.16K (2.30%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 7 | Polar Capital Biotech S Inc | 750.00K (2.19%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 8 | Janus Global Life Science AUSD | 745.08K (2.17%) | -5.82K Decreased by -0.78% | Dec 31, 24 |
| 9 | Janus Selection Global Life Science AUSD | 744.60K (2.17%) | -46.09K Decreased by -6.19% | Jun 30, 24 |
| 10 | Janus Henderson Glb Life Scn I2 USD | 740.19K (2.16%) | -1.63K Decreased by -0.22% | Feb 28, 25 |
| 11 | Fidelity Small Cap Index | 502.68K (1.47%) | -9.41K Decreased by -1.87% | Jan 31, 25 |
| 12 | Vanguard Institutional Extnd Mkt Idx Tr | 496.21K (1.45%) | 21.21K Increased by +4.27% | Feb 28, 25 |
| 13 | Fidelity Growth Compy Commingled Pl O | 469.24K (1.37%) | 521.00 Increased by +0.11% | Jun 30, 24 |
| 14 | Eventide Healthcare & Life Sciences I | 422.86K (1.23%) | -458.30K Decreased by -108.38% | Sep 30, 24 |
| 15 | Xtrackers S&P Global Infra Swap ETF 1C | 376.50K (1.10%) | -200.60K Decreased by -53.28% | Oct 31, 24 |
| 16 | Fidelity® Small Cap Index | 376.39K (1.10%) | 8.96K Increased by +2.38% | Oct 31, 23 |
| 17 | MEDICAL BioHealth EUR Acc | 354.68K (1.03%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 18 | Fidelity Growth Company Fund | 351.56K (1.02%) | -1.20K Decreased by -0.34% | Jun 30, 24 |
| 19 | State St Russell Sm/Mid Cp® Indx NL Cl C | 296.89K (0.87%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 20 | JPM Thematics Genetic Thrps C2 Acc USD | 273.78K (0.80%) | -11.27K Decreased by -4.12% | Oct 31, 24 |