| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 4.56M (12.89%) | -535.00K Decreased by -11.72% | Dec 31, 24 |
| 2 | Bvf Inc | 4.56M (12.89%) | 1.89M Increased by +41.45% | Mar 31, 25 |
| 3 | BlackRock Inc | 4.55M (12.85%) | -374.17K Decreased by -8.23% | Mar 31, 25 |
| 4 | Goldman Sachs Group Inc | 4.17M (11.78%) | -106.58K Decreased by -2.56% | Mar 31, 25 |
| 5 | Viking Global Investors LP | 2.93M (8.29%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 6 | Vanguard Group Inc | 2.76M (7.79%) | -103.02K Decreased by -3.74% | Mar 31, 25 |
| 7 | State Street Corporation | 2.18M (6.15%) | 654.24K Increased by +30.04% | Mar 31, 24 |
| 8 | Novo A/S | 1.95M (5.51%) | 450.00K Increased by +23.08% | Mar 31, 25 |
| 9 | HHG PLC | 1.89M (5.35%) | -360.31K Decreased by -19.04% | Mar 31, 25 |
| 10 | Morgan Stanley - Brokerage Accounts | 1.78M (5.02%) | -86.31K Decreased by -4.86% | Mar 31, 25 |
| 11 | Millennium Management LLC | 1.42M (4.01%) | 1.34M Increased by +94.14% | Dec 31, 24 |
| 12 | Federated Hermes Inc | 1.25M (3.53%) | 1.25M Increased by +99.70% | Mar 31, 25 |
| 13 | BRAIDWELL LP | 1.23M (3.46%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 14 | Redmile Group, LLC | 1.20M (3.38%) | -65.18K Decreased by -5.45% | Dec 31, 24 |
| 15 | Casdin Capital, LLC | 1.15M (3.25%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 16 | State Street Corp | 1.03M (2.90%) | -84.77K Decreased by -8.25% | Mar 31, 25 |
| 17 | FMR Inc | 1.02M (2.87%) | 47.34K Increased by +4.66% | Jun 30, 24 |
| 18 | Geode Capital Management, LLC | 963.27K (2.72%) | -48.89K Decreased by -5.08% | Mar 31, 25 |
| 19 | JPMorgan Chase & Co | 886.71K (2.51%) | 66.64K Increased by +7.52% | Mar 31, 25 |
| 20 | Eventide Asset Management, LLC | 881.16K (2.49%) | 105.04K Increased by +11.92% | Jun 30, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 1.54M (4.34%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 2 | Vanguard US Total Market Shares ETF | 1.54M (4.34%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | iShares Russell 2000 ETF | 1.14M (3.23%) | 193.00 Increased by +0.02% | Apr 30, 25 |
| 4 | SPDR® S&P Biotech ETF | 990.08K (2.80%) | -30.06K Decreased by -3.04% | Nov 27, 24 |
| 5 | Janus Henderson Global Life Sciences D | 952.09K (2.69%) | 66.22K Increased by +6.96% | Mar 31, 25 |
| 6 | Janus Henderson Global Life Sciences | 902.96K (2.55%) | -113.28K Decreased by -12.55% | Dec 31, 24 |
| 7 | Federated Hermes MDT SCC Institutional | 866.66K (2.45%) | 866.66K Increased by +100.00% | Mar 31, 25 |
| 8 | Federated Hermes MDT Small Cap Core IS | 866.66K (2.45%) | 866.66K Increased by +100.00% | Mar 31, 25 |
| 9 | Polar Capital Healthcare Opports Inc | 790.16K (2.23%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 10 | Polar Capital Biotech S Inc | 750.00K (2.12%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 11 | Janus Selection Global Life Science AUSD | 744.60K (2.10%) | -46.09K Decreased by -6.19% | Jun 30, 24 |
| 12 | Janus Global Life Science AUSD | 738.42K (2.09%) | -6.66K Decreased by -0.90% | Mar 31, 25 |
| 13 | Janus Henderson Glb Life Scn I2 USD | 738.42K (2.09%) | -1.77K Decreased by -0.24% | Mar 31, 25 |
| 14 | Fidelity Small Cap Index | 502.68K (1.42%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 15 | Vanguard Institutional Extnd Mkt Idx Tr | 496.21K (1.40%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 16 | Fidelity Growth Compy Commingled Pl O | 469.24K (1.33%) | 521.00 Increased by +0.11% | Jun 30, 24 |
| 17 | Eventide Healthcare & Life Sciences I | 422.86K (1.19%) | -458.30K Decreased by -108.38% | Sep 30, 24 |
| 18 | Xtrackers S&P Global Infra Swap ETF 1C | 376.50K (1.06%) | -200.60K Decreased by -53.28% | Oct 31, 24 |
| 19 | Fidelity® Small Cap Index | 376.39K (1.06%) | 8.96K Increased by +2.38% | Oct 31, 23 |
| 20 | MEDICAL BioHealth EUR Acc | 354.68K (1.00%) | 0.00 Increased by 0.00% | Dec 31, 24 |