| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Redmile Group, LLC | 12.87M (13.94%) | -296.11K Decreased by -2.30% | Dec 31, 24 |
| 2 | BlackRock Inc | 10.68M (11.57%) | -259.80K Decreased by -2.43% | Mar 31, 25 |
| 3 | Vanguard Group Inc | 10.31M (11.17%) | -22.58K Decreased by -0.22% | Mar 31, 25 |
| 4 | State Street Corporation | 8.04M (8.70%) | 6.17M Increased by +76.83% | Mar 31, 24 |
| 5 | Deep Track Capital, LP | 5.57M (6.04%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 6 | Boxer Capital LLC | 4.96M (5.37%) | -3.25M Decreased by -65.61% | Sep 30, 24 |
| 7 | Bellevue Group AG | 4.84M (5.24%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 8 | Citadel Advisors Llc | 4.38M (4.75%) | 100.18K Increased by +2.29% | Dec 31, 24 |
| 9 | Deerfield Management Co | 3.56M (3.85%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 10 | JPMorgan Chase & Co | 3.40M (3.68%) | 1.73M Increased by +50.87% | Mar 31, 25 |
| 11 | Johnson & Johnson | 3.38M (3.66%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 12 | Baker Bros Advisors LP | 3.26M (3.53%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 13 | EcoR1 Capital, LLC | 3.05M (3.30%) | 3.05M Increased by +100.00% | Dec 31, 24 |
| 14 | Dimensional Fund Advisors, Inc. | 2.59M (2.81%) | -306.82K Decreased by -11.84% | Mar 31, 25 |
| 15 | Suvretta Capital Management, LLC | 2.56M (2.78%) | 2.56M Increased by +100.00% | Mar 31, 24 |
| 16 | Holocene Advisors, LP | 2.53M (2.74%) | 2.53M Increased by +100.00% | Mar 31, 24 |
| 17 | Vestal Point Capital LP | 2.46M (2.67%) | 780.00K Increased by +31.64% | Dec 31, 24 |
| 18 | Goldman Sachs Group Inc | 2.46M (2.66%) | -17.44K Decreased by -0.71% | Mar 31, 25 |
| 19 | Assenagon Asset Management SA | 2.43M (2.64%) | -140.50K Decreased by -5.77% | Sep 30, 24 |
| 20 | Geode Capital Management, LLC | 2.27M (2.46%) | 42.64K Increased by +1.88% | Mar 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BB Biotech AG Ord | 4.84M (5.24%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 3.05M (3.30%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 3 | Vanguard US Total Market Shares ETF | 3.05M (3.30%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | Vanguard Strategic Equity Inv | 2.54M (2.75%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 5 | iShares Russell 2000 ETF | 2.45M (2.65%) | 413.00 Increased by +0.02% | Apr 30, 25 |
| 6 | SPDR® S&P Biotech ETF | 2.35M (2.54%) | -71.37K Decreased by -3.04% | Nov 27, 24 |
| 7 | Vanguard Institutional Extnd Mkt Idx Tr | 1.40M (1.52%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 8 | Vanguard Explorer Inv | 1.27M (1.37%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 9 | JPMorgan US Small Company L | 1.19M (1.29%) | -677.59K Decreased by -56.93% | Mar 31, 25 |
| 10 | Vanguard Small Cap Index | 1.08M (1.17%) | 3.34K Increased by +0.31% | Nov 30, 23 |
| 11 | Fidelity Small Cap Index | 1.01M (1.09%) | 35.37K Increased by +3.50% | Feb 28, 25 |
| 12 | BlackRock Advantage Small Cap Core Instl | 955.56K (1.03%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 13 | iShares Russell 2000 Value ETF | 925.01K (1.00%) | -3.14K Decreased by -0.34% | Apr 30, 25 |
| 14 | Fidelity® Small Cap Index | 812.70K (0.88%) | 13.38K Increased by +1.65% | Oct 31, 23 |
| 15 | DFA US Targeted Value I | 746.55K (0.81%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 16 | Biotech Growth Ord | 687.00K (0.74%) | 687.00K Increased by +100.00% | Jan 31, 25 |
| 17 | Federated Hermes MDT SCC Institutional | 666.78K (0.72%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 18 | iShares Biotechnology ETF | 644.10K (0.70%) | 1.47K Increased by +0.23% | Apr 30, 25 |
| 19 | State St Russell Sm/Mid Cp® Indx NL Cl C | 638.96K (0.69%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 20 | State St Russell Sm/Mid Cp® Indx SL Cl I | 638.96K (0.69%) | 0.00 Increased by 0.00% | Apr 30, 25 |