| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | HHG PLC | 20.46M (20.14%) | 3.95M Increased by +19.30% | Mar 31, 25 |
| 2 | RA Capital Management, LLC | 19.89M (19.58%) | 5.71M Increased by +28.73% | Mar 31, 25 |
| 3 | Suvretta Capital Management, LLC | 14.34M (14.11%) | 4.13M Increased by +28.83% | Mar 31, 25 |
| 4 | BlackRock Inc | 10.08M (9.92%) | 2.19M Increased by +21.69% | Mar 31, 25 |
| 5 | Deep Track Capital, LP | 9.32M (9.17%) | 2.84M Increased by +30.46% | Mar 31, 25 |
| 6 | Vanguard Group Inc | 7.16M (7.05%) | 1.47M Increased by +20.54% | Mar 31, 25 |
| 7 | venBio Select Advisor LLC | 6.35M (6.25%) | 2.25M Increased by +35.43% | Mar 31, 25 |
| 8 | State Street Corporation | 5.54M (5.46%) | 144.23K Increased by +2.60% | Mar 31, 24 |
| 9 | Citadel Advisors Llc | 5.09M (5.01%) | 356.98K Increased by +7.02% | Mar 31, 25 |
| 10 | Bvf Inc | 4.33M (4.27%) | -2.48M Decreased by -57.17% | Dec 31, 24 |
| 11 | Pictet Asset Manangement SA | 4.20M (4.14%) | 1.20M Increased by +28.49% | Mar 31, 25 |
| 12 | State Street Corp | 4.03M (3.97%) | 1.09M Increased by +26.92% | Mar 31, 25 |
| 13 | Westfield Capital Management Company, L.P. | 3.89M (3.83%) | 7.95K Increased by +0.20% | Mar 31, 25 |
| 14 | Holocene Advisors, LP | 3.45M (3.40%) | 1.21M Increased by +35.21% | Mar 31, 24 |
| 15 | Westfield Capital Management Company, LP | 3.01M (2.96%) | 686.67K Increased by +22.84% | Sep 30, 24 |
| 16 | Geode Capital Management, LLC | 2.90M (2.85%) | 690.37K Increased by +23.82% | Mar 31, 25 |
| 17 | Logos Global Management LP | 2.50M (2.46%) | 2.50M Increased by +100.00% | Mar 31, 25 |
| 18 | Polar Capital Holdings PLC | 2.50M (2.46%) | 2.50M Increased by +100.00% | Mar 31, 25 |
| 19 | RTW INVESTMENTS, LLC | 1.97M (1.94%) | -5.51M Decreased by -280.07% | Mar 31, 25 |
| 20 | Federated Hermes Inc | 1.96M (1.93%) | -167.03K Decreased by -8.51% | Dec 31, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 3.99M (3.92%) | 16.20K Increased by +0.41% | Apr 30, 25 |
| 2 | Janus Henderson Global Life Sciences | 2.97M (2.92%) | 206.63K Increased by +6.96% | Mar 31, 25 |
| 3 | Janus Henderson Global Life Sciences D | 2.97M (2.92%) | -10.97K Decreased by -0.37% | Mar 31, 25 |
| 4 | iShares Russell 2000 ETF | 2.81M (2.76%) | 0.00 Increased by 0.00% | May 31, 25 |
| 5 | Vanguard US Total Market Shares ETF | 2.65M (2.60%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 6 | Polar Capital Biotech S Inc | 2.50M (2.46%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 7 | Janus Global Life Science AUSD | 2.42M (2.38%) | 225.46K Increased by +9.32% | Mar 31, 25 |
| 8 | Janus Henderson Glb Life Scn I2 USD | 2.38M (2.35%) | -34.76K Decreased by -1.46% | Apr 30, 25 |
| 9 | Janus Henderson Triton D | 2.37M (2.34%) | -24.70K Decreased by -1.04% | Mar 31, 25 |
| 10 | Janus Henderson US SMID Cap Growth | 2.37M (2.34%) | 675.73K Increased by +28.48% | Mar 31, 25 |
| 11 | Pictet-Biotech P USD | 2.29M (2.25%) | -89.58K Decreased by -3.91% | Feb 28, 25 |
| 12 | Janus Selection Global Life Science AUSD | 2.19M (2.16%) | -95.51K Decreased by -4.36% | Jun 30, 24 |
| 13 | Pictet Biotech | 2.04M (2.00%) | 2.04M Increased by +100.00% | Mar 31, 24 |
| 14 | Harbor Small Cap Growth Instl | 1.97M (1.94%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 15 | Westfield Capital Mgt Co Sm-Cap Gr Eq | 1.97M (1.94%) | -24.52K Decreased by -1.24% | Mar 31, 25 |
| 16 | Vanguard Institutional Extnd Mkt Idx Tr | 1.94M (1.91%) | 17.76K Increased by +0.92% | Apr 30, 25 |
| 17 | Janus Henderson US SMID Cap Growth MA | 1.70M (1.67%) | 1.70M Increased by +100.00% | Dec 31, 24 |
| 18 | SPDR® S&P Biotech ETF | 1.58M (1.55%) | 9.34K Increased by +0.59% | May 31, 25 |
| 19 | Pictet-Global Megatrend Sel I USD | 1.54M (1.52%) | 1.54M Increased by +100.00% | Feb 28, 25 |
| 20 | Janus Henderson Hrzn Biotec E2 USD | 1.19M (1.17%) | 432.02K Increased by +36.44% | Mar 31, 25 |