| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | HHG PLC | 16.51M (15.36%) | 1.36M Increased by +8.21% | Dec 31, 24 |
| 2 | RA Capital Management, LLC | 14.18M (13.18%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 3 | Suvretta Capital Management, LLC | 10.20M (9.49%) | 2.21M Increased by +21.67% | Dec 31, 24 |
| 4 | BlackRock Inc | 7.89M (7.34%) | 340.80K Increased by +4.32% | Dec 31, 24 |
| 5 | RTW INVESTMENTS, LLC | 7.48M (6.95%) | 99.51K Increased by +1.33% | Dec 31, 24 |
| 6 | Deep Track Capital, LP | 6.48M (6.02%) | 3.71M Increased by +57.30% | Dec 31, 24 |
| 7 | Vanguard Group Inc | 5.69M (5.29%) | 686.05K Increased by +12.05% | Dec 31, 24 |
| 8 | State Street Corporation | 5.54M (5.16%) | 144.23K Increased by +2.60% | Mar 31, 24 |
| 9 | Citadel Advisors Llc | 4.73M (4.40%) | 2.17M Increased by +45.94% | Dec 31, 24 |
| 10 | Bvf Inc | 4.33M (4.03%) | -2.48M Decreased by -57.17% | Dec 31, 24 |
| 11 | venBio Select Advisor LLC | 4.10M (3.81%) | 4.10M Increased by +100.00% | Dec 31, 24 |
| 12 | Westfield Capital Management Company, L.P. | 3.89M (3.61%) | 880.76K Increased by +22.66% | Dec 31, 24 |
| 13 | Holocene Advisors, LP | 3.45M (3.21%) | 1.21M Increased by +35.21% | Mar 31, 24 |
| 14 | Pictet Asset Manangement SA | 3.01M (2.80%) | -239.57K Decreased by -7.97% | Dec 31, 24 |
| 15 | Westfield Capital Management Company, LP | 3.01M (2.80%) | 686.67K Increased by +22.84% | Sep 30, 24 |
| 16 | State Street Corp | 2.95M (2.74%) | -306.45K Decreased by -10.41% | Dec 31, 24 |
| 17 | Geode Capital Management, LLC | 2.21M (2.05%) | 132.64K Increased by +6.01% | Dec 31, 24 |
| 18 | Redmile Group, LLC | 2.17M (2.02%) | 597.33K Increased by +27.56% | Dec 31, 24 |
| 19 | Federated Hermes Inc | 1.96M (1.83%) | -167.03K Decreased by -8.51% | Dec 31, 23 |
| 20 | BRAIDWELL LP | 1.59M (1.48%) | 1.59M Increased by +100.00% | Sep 30, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 3.97M (3.69%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 2 | Janus Henderson Global Life Sciences D | 3.00M (2.79%) | 235.15K Increased by +7.85% | Jan 31, 25 |
| 3 | iShares Russell 2000 ETF | 2.93M (2.72%) | -25.36K Decreased by -0.87% | Mar 31, 25 |
| 4 | Janus Henderson Global Life Sciences | 2.76M (2.57%) | -195.87K Decreased by -7.09% | Dec 31, 24 |
| 5 | Janus Henderson Glb Life Scn I2 USD | 2.42M (2.25%) | 19.69K Increased by +0.81% | Feb 28, 25 |
| 6 | Janus Henderson Triton D | 2.40M (2.23%) | 700.43K Increased by +29.21% | Jan 31, 25 |
| 7 | Janus Global Life Science AUSD | 2.19M (2.04%) | -9.33K Decreased by -0.43% | Dec 31, 24 |
| 8 | Janus Selection Global Life Science AUSD | 2.19M (2.04%) | -95.51K Decreased by -4.36% | Jun 30, 24 |
| 9 | Pictet Biotech | 2.04M (1.89%) | 2.04M Increased by +100.00% | Mar 31, 24 |
| 10 | Pictet-Biotech P USD | 2.04M (1.89%) | -3.75K Decreased by -0.18% | Dec 31, 24 |
| 11 | Westfield Capital Mgt Co Sm-Cap Gr Eq | 1.99M (1.86%) | 547.51K Increased by +27.45% | Dec 31, 24 |
| 12 | Harbor Small Cap Growth Instl | 1.97M (1.83%) | -24.52K Decreased by -1.24% | Jan 31, 25 |
| 13 | Vanguard Institutional Extnd Mkt Idx Tr | 1.86M (1.73%) | 2.81K Increased by +0.15% | Feb 28, 25 |
| 14 | Janus Henderson US SMID Cap Growth | 1.70M (1.58%) | 311.50K Increased by +18.35% | Dec 31, 24 |
| 15 | Janus Henderson US SMID Cap Growth MA | 1.70M (1.58%) | 1.70M Increased by +100.00% | Dec 31, 24 |
| 16 | SPDR® S&P Biotech ETF | 1.68M (1.56%) | -18.01K Decreased by -1.07% | Mar 31, 25 |
| 17 | Pictet-Global Megatrend Sel I USD | 1.19M (1.11%) | -188.49K Decreased by -15.82% | Aug 31, 24 |
| 18 | Janus Henderson Venture D | 1.15M (1.07%) | 362.84K Increased by +31.62% | Jan 31, 25 |
| 19 | Federated Hermes Kaufmann Growth | 1.09M (1.01%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 20 | Federated Hermes Kaufmann R | 1.09M (1.01%) | 0.00 Increased by 0.00% | Sep 30, 23 |