| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Frazier Life Sciences Management, L.P. | 22.73M (10.93%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | T. Rowe Price Investment Management,Inc. | 20.90M (10.05%) | 666.33K Increased by +3.19% | Dec 31, 25 |
| 3 | VR Adviser, LLC | 17.86M (8.59%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 4 | RTW INVESTMENTS, LLC | 16.16M (7.77%) | 16.01M Increased by +99.09% | Mar 31, 26 |
| 5 | BlackRock Inc | 15.60M (7.50%) | 526.01K Increased by +3.37% | Dec 31, 25 |
| 6 | Vanguard Group Inc | 12.81M (6.16%) | 324.00 Increased by +0.00% | Dec 31, 25 |
| 7 | Logos Global Management LP | 11.15M (5.36%) | -1.85M Decreased by -16.59% | Mar 31, 26 |
| 8 | Paradigm Biocapital Advisors LP | 10.39M (5.00%) | -3.77M Decreased by -36.24% | Mar 31, 26 |
| 9 | Vivo Capital, LLC | 9.27M (4.46%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 10 | Siren, L.L.C. | 8.76M (4.21%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 11 | ARCH VENTURE CORP | 7.09M (3.41%) | -3.96M Decreased by -55.90% | Mar 31, 26 |
| 12 | State Street Corp | 6.17M (2.97%) | 2.15M Increased by +34.75% | Dec 31, 25 |
| 13 | Armistice Capital, LLC | 6.17M (2.97%) | -1.92M Decreased by -31.17% | Mar 31, 24 |
| 14 | Cormorant Asset Management, LLC | 5.80M (2.79%) | 5.80M Increased by +100.00% | Mar 31, 26 |
| 15 | Octagon Capital Advisors LP | 5.14M (2.47%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 16 | Geode Capital Management, LLC | 4.93M (2.37%) | 77.77K Increased by +1.58% | Dec 31, 25 |
| 17 | Artal Group S A | 4.72M (2.27%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 18 | Citadel Advisors Llc | 4.29M (2.06%) | -27.30K Decreased by -0.64% | Dec 31, 24 |
| 19 | HHG PLC | 4.11M (1.98%) | -4.07M Decreased by -99.00% | Sep 30, 24 |
| 20 | Affinity Asset Advisors, LLC | 3.90M (1.88%) | -385.79K Decreased by -9.89% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 8.31M (4.00%) | 100.10K Increased by +1.20% | Mar 31, 26 |
| 2 | State Street® SPDR® S&P® Biotech ETF | 5.29M (2.54%) | -37.58K Decreased by -0.71% | Apr 30, 26 |
| 3 | iShares Russell 2000 ETF | 4.48M (2.15%) | 37.74K Increased by +0.84% | Apr 30, 26 |
| 4 | T. Rowe Price U.S. SC Value Eq Tr-Z | 2.91M (1.40%) | 147.12K Increased by +5.05% | Mar 31, 25 |
| 5 | Vanguard Institutional Extnd Mkt Idx Tr | 2.67M (1.28%) | 96.37K Increased by +3.62% | Mar 31, 26 |
| 6 | T. Rowe Price Small-Cap Stock | 2.55M (1.23%) | -1.68M Decreased by -66.02% | Mar 31, 26 |
| 7 | T. Rowe Price US Small-Cap Core Equity | 2.55M (1.23%) | -477.53K Decreased by -18.75% | Mar 31, 26 |
| 8 | SPDR® S&P Biotech ETF | 2.23M (1.07%) | -13.57K Decreased by -0.61% | Feb 28, 25 |
| 9 | International Biotechnology Ord | 1.93M (0.93%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 10 | T. Rowe Price U.S. SC Core Eq Tr-Z | 1.82M (0.88%) | 27.83K Increased by +1.53% | Mar 31, 25 |
| 11 | T. Rowe Price Small-Cap Value | 1.80M (0.86%) | -1.71M Decreased by -95.06% | Mar 31, 26 |
| 12 | Fidelity Small Cap Index | 1.70M (0.82%) | 12.67K Increased by +0.75% | Feb 28, 26 |
| 13 | iShares Russell 2000 Value ETF | 1.62M (0.78%) | 8.74K Increased by +0.54% | Apr 30, 26 |
| 14 | JNL/T. Rowe Price Capital Appreciation A | 1.46M (0.70%) | 1.46M Increased by +100.00% | Mar 31, 26 |
| 15 | iShares Biotechnology ETF | 1.37M (0.66%) | 19.35K Increased by +1.41% | Apr 30, 26 |
| 16 | T. Rowe Price US Smlr Cm Eq A USD | 1.35M (0.65%) | -69.10K Decreased by -5.13% | Apr 30, 25 |
| 17 | T. Rowe Price Instl Small-Cap Stock | 1.32M (0.64%) | -990.73K Decreased by -74.90% | Mar 31, 26 |
| 18 | Fidelity Extended Market Index | 1.27M (0.61%) | 36.43K Increased by +2.88% | Mar 31, 26 |
| 19 | T. Rowe Price U.S. SC Core Eq Tr-D | 1.26M (0.61%) | -132.58K Decreased by -10.50% | Mar 31, 26 |
| 20 | T. Rowe Price U.S. SC Value Eq Tr-D | 1.18M (0.57%) | -1.69M Decreased by -142.94% | Mar 31, 26 |