| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Frazier Life Sciences Management, L.P. | 24.68M (11.87%) | 1.95M Increased by +7.89% | Mar 31, 26 |
| 2 | T. Rowe Price Investment Management,Inc. | 21.26M (10.23%) | 361.41K Increased by +1.70% | Mar 31, 26 |
| 3 | BlackRock Inc | 20.15M (9.69%) | 4.55M Increased by +22.60% | Mar 31, 26 |
| 4 | VR Adviser, LLC | 16.38M (7.88%) | -1.47M Decreased by -9.00% | Mar 31, 26 |
| 5 | RTW INVESTMENTS, LLC | 16.16M (7.77%) | 16.01M Increased by +99.09% | Mar 31, 26 |
| 6 | Vanguard Group Inc | 12.81M (6.16%) | 324.00 Increased by +0.00% | Dec 31, 25 |
| 7 | Vivo Capital, LLC | 12.15M (5.85%) | 2.88M Increased by +23.68% | Mar 31, 26 |
| 8 | Vanguard Capital Management, LLC | 11.25M (5.41%) | 11.25M Increased by +100.00% | Mar 31, 26 |
| 9 | Siren, L.L.C. | 11.24M (5.41%) | 2.49M Increased by +22.12% | Mar 31, 26 |
| 10 | Logos Global Management LP | 11.15M (5.36%) | -1.85M Decreased by -16.59% | Mar 31, 26 |
| 11 | Paradigm Biocapital Advisors LP | 10.39M (5.00%) | -3.77M Decreased by -36.24% | Mar 31, 26 |
| 12 | State Street Corp | 9.30M (4.47%) | 3.13M Increased by +33.61% | Mar 31, 26 |
| 13 | ARCH VENTURE CORP | 7.09M (3.41%) | -3.96M Decreased by -55.90% | Mar 31, 26 |
| 14 | Armistice Capital, LLC | 6.17M (2.97%) | -1.92M Decreased by -31.17% | Mar 31, 24 |
| 15 | Geode Capital Management, LLC | 6.00M (2.88%) | 1.07M Increased by +17.84% | Mar 31, 26 |
| 16 | Cormorant Asset Management, LLC | 5.80M (2.79%) | 5.80M Increased by +100.00% | Mar 31, 26 |
| 17 | Affinity Asset Advisors, LLC | 5.35M (2.57%) | 1.45M Increased by +27.10% | Mar 31, 26 |
| 18 | Balyasny Asset Management LLC | 5.14M (2.47%) | 5.05M Increased by +98.09% | Mar 31, 26 |
| 19 | Octagon Capital Advisors LP | 5.14M (2.47%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 20 | The Goldman Sachs Group Inc | 4.88M (2.35%) | 1.54M Increased by +31.67% | Mar 31, 26 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 8.38M (4.03%) | 67.72K Increased by +0.81% | Apr 30, 26 |
| 2 | State Street® SPDR® S&P® Biotech ETF | 5.24M (2.52%) | -32.23K Decreased by -0.62% | May 31, 26 |
| 3 | iShares Russell 2000 ETF | 4.55M (2.19%) | 42.07K Increased by +0.92% | May 29, 26 |
| 4 | T. Rowe Price U.S. SC Value Eq Tr-Z | 2.91M (1.40%) | 147.12K Increased by +5.05% | Mar 31, 25 |
| 5 | Vanguard Institutional Extnd Mkt Idx Tr | 2.69M (1.30%) | 27.98K Increased by +1.04% | Apr 30, 26 |
| 6 | T. Rowe Price Small-Cap Stock | 2.57M (1.23%) | 19.41K Increased by +0.76% | Apr 30, 26 |
| 7 | T. Rowe Price US Small-Cap Core Equity | 2.55M (1.23%) | -477.53K Decreased by -18.75% | Mar 31, 26 |
| 8 | SPDR® S&P Biotech ETF | 2.23M (1.07%) | -13.57K Decreased by -0.61% | Feb 28, 25 |
| 9 | International Biotechnology Ord | 1.93M (0.93%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 10 | Fidelity Small Cap Index | 1.86M (0.89%) | 160.86K Increased by +8.65% | Mar 31, 26 |
| 11 | T. Rowe Price U.S. SC Core Eq Tr-Z | 1.82M (0.88%) | 27.83K Increased by +1.53% | Mar 31, 25 |
| 12 | iShares Russell 2000 Value ETF | 1.65M (0.79%) | 16.31K Increased by +0.99% | May 29, 26 |
| 13 | JNL/T. Rowe Price Capital Appreciation A | 1.46M (0.70%) | 1.46M Increased by +100.00% | Mar 31, 26 |
| 14 | Fidelity Select Biotechnology | 1.43M (0.69%) | 516.70K Increased by +36.17% | Apr 30, 26 |
| 15 | T. Rowe Price Small-Cap Value | 1.42M (0.69%) | -371.34K Decreased by -26.06% | Apr 30, 26 |
| 16 | iShares Biotechnology ETF | 1.36M (0.66%) | 19.75K Increased by +1.45% | May 29, 26 |
| 17 | T. Rowe Price Instl Small-Cap Stock | 1.36M (0.66%) | 41.27K Increased by +3.03% | Apr 30, 26 |
| 18 | T. Rowe Price US Smlr Cm Eq A USD | 1.35M (0.65%) | -69.10K Decreased by -5.13% | Apr 30, 25 |
| 19 | Victory Pioneer Select Mid Cap Growth A | 1.34M (0.64%) | 439.11K Increased by +32.85% | Mar 31, 26 |
| 20 | Fidelity Extended Market Index | 1.27M (0.61%) | 311.00 Increased by +0.02% | Apr 30, 26 |