| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Avidity Partners Management LP | 6.36M (7.57%) | 310.00K Increased by +4.87% | Dec 31, 23 |
| 2 | State Street Corporation | 5.12M (6.09%) | -233.72K Decreased by -4.57% | Dec 31, 23 |
| 3 | Pfizer Inc | 4.69M (5.58%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 4 | Vanguard Group Inc | 4.09M (4.87%) | -432.17K Decreased by -10.57% | Jun 30, 25 |
| 5 | Deerfield Management Co | 3.50M (4.16%) | 3.50M Increased by +100.00% | Sep 30, 23 |
| 6 | Alkeon Capital Management, LLC | 3.11M (3.70%) | 1.47M Increased by +47.17% | Dec 31, 23 |
| 7 | Kynam Capital Management, LP | 3.07M (3.65%) | -201.37K Decreased by -6.56% | Jun 30, 25 |
| 8 | Paradigm Biocapital Advisors LP | 2.92M (3.48%) | -20.66K Decreased by -0.71% | Dec 31, 23 |
| 9 | Morgan Stanley - Brokerage Accounts | 2.75M (3.27%) | 1.55M Increased by +56.42% | Dec 31, 24 |
| 10 | Rokos Capital Management LLP | 2.75M (3.27%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 11 | Assenagon Asset Management SA | 2.65M (3.15%) | 1.89M Increased by +71.23% | Sep 30, 23 |
| 12 | Schonfeld Strategic Advisors LLC | 2.27M (2.70%) | -78.72K Decreased by -3.46% | Jun 30, 25 |
| 13 | Elmwood Wealth Management, Inc. | 2.03M (2.41%) | -150.00K Decreased by -7.40% | Dec 31, 24 |
| 14 | BlackRock Inc | 1.88M (2.24%) | -4.46M Decreased by -236.95% | Jun 30, 25 |
| 15 | State Street Corp | 1.64M (1.95%) | -16.38K Decreased by -1.00% | Mar 31, 25 |
| 16 | Millennium Management LLC | 1.55M (1.84%) | 729.54K Increased by +47.05% | Jun 30, 25 |
| 17 | Two Sigma Advisers, LLC | 1.45M (1.72%) | -59.40K Decreased by -4.10% | Jun 30, 25 |
| 18 | Partner Fund Management LP | 1.36M (1.62%) | -1.15M Decreased by -84.46% | Jun 30, 25 |
| 19 | Dimensional Fund Advisors, Inc. | 1.31M (1.56%) | -77.31K Decreased by -5.91% | Jun 30, 25 |
| 20 | Woodline Partners LP | 1.14M (1.36%) | 679.13K Increased by +59.54% | Dec 31, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | SPDR® S&P Biotech ETF | 4.54M (5.40%) | 24.19K Increased by +0.53% | Mar 31, 24 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 2.64M (3.14%) | -58.31K Decreased by -2.21% | Jul 31, 25 |
| 3 | ACATIS Datini Valueflex Fonds A | 2.00M (2.38%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 4 | Selectra J. Lamarck Biotech A | 1.50M (1.78%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 5 | abrdn Life Sciences Investors | 1.39M (1.65%) | 595.41K Increased by +42.87% | Aug 31, 25 |
| 6 | Belfius Equities Cure C Cap | 1.15M (1.36%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 7 | Pictet-Biotech P USD | 1.09M (1.30%) | -241.00K Decreased by -22.12% | Jun 30, 23 |
| 8 | Vanguard Institutional Extnd Mkt Idx Tr | 884.56K (1.05%) | -346.95K Decreased by -39.22% | Jul 31, 25 |
| 9 | Candriam Global Equities Oncology | 860.00K (1.02%) | 360.00K Increased by +41.86% | Dec 31, 23 |
| 10 | Fidelity Small Cap Index | 843.92K (1.00%) | 0.00 Increased by 0.00% | May 31, 25 |
| 11 | iShares Russell 2000 Value ETF | 762.12K (0.91%) | 0.00 Increased by 0.00% | May 31, 25 |
| 12 | Fidelity® Small Cap Index | 724.39K (0.86%) | 22.01K Increased by +3.04% | Oct 31, 23 |
| 13 | Pictet-Global Megatrend Sel I USD | 672.75K (0.80%) | 1.38K Increased by +0.20% | Dec 31, 23 |
| 14 | iShares Biotechnology ETF | 561.24K (0.67%) | 570.00 Increased by +0.10% | Nov 27, 24 |
| 15 | Direxion Daily S&P Biotech Bull 3X ETF | 541.45K (0.64%) | -3.80K Decreased by -0.70% | Mar 31, 24 |
| 16 | Fidelity Extended Market Index | 480.70K (0.57%) | 21.67K Increased by +4.51% | Jul 31, 25 |
| 17 | State St Russell Sm/Mid Cp® Indx NL Cl C | 478.79K (0.57%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 18 | State St Russell Sm/Mid Cp® Indx SL Cl I | 478.79K (0.57%) | 0.00 Increased by 0.00% | May 31, 25 |
| 19 | Vanguard Russell 2000 ETF | 411.14K (0.49%) | 3.71K Increased by +0.90% | May 31, 25 |
| 20 | Fidelity® Extended Market Index | 405.44K (0.48%) | 0.00 Increased by 0.00% | Nov 30, 23 |