| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Avidity Partners Management LP | 6.36M (6.71%) | 310.00K Increased by +4.87% | Dec 31, 23 |
| 2 | State Street Corporation | 5.12M (5.40%) | -233.72K Decreased by -4.57% | Dec 31, 23 |
| 3 | Pfizer Inc | 4.69M (4.95%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 4 | Vanguard Group Inc | 4.30M (4.54%) | 77.27K Increased by +1.80% | Dec 31, 25 |
| 5 | Vanguard Capital Management, LLC | 3.77M (3.97%) | 3.77M Increased by +100.00% | Mar 31, 26 |
| 6 | Deerfield Management Co | 3.50M (3.69%) | 3.50M Increased by +100.00% | Sep 30, 23 |
| 7 | Alkeon Capital Management, LLC | 3.11M (3.28%) | 1.47M Increased by +47.17% | Dec 31, 23 |
| 8 | Paradigm Biocapital Advisors LP | 2.92M (3.08%) | -20.66K Decreased by -0.71% | Dec 31, 23 |
| 9 | Morgan Stanley - Brokerage Accounts | 2.75M (2.90%) | 1.55M Increased by +56.42% | Dec 31, 24 |
| 10 | Rokos Capital Management LLP | 2.75M (2.90%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 11 | Assenagon Asset Management SA | 2.65M (2.79%) | 1.89M Increased by +71.23% | Sep 30, 23 |
| 12 | Renaissance Technologies Corp | 2.59M (2.73%) | 950.64K Increased by +36.70% | Mar 31, 26 |
| 13 | Kynam Capital Management, LP | 2.50M (2.64%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 14 | Schonfeld Strategic Advisors LLC | 2.27M (2.40%) | -78.72K Decreased by -3.46% | Jun 30, 25 |
| 15 | BlackRock Inc | 2.14M (2.26%) | 2.06K Increased by +0.10% | Mar 31, 26 |
| 16 | Elmwood Wealth Management, Inc. | 2.03M (2.14%) | -150.00K Decreased by -7.40% | Dec 31, 24 |
| 17 | Two Sigma Investments LLC | 1.76M (1.86%) | 739.86K Increased by +42.04% | Mar 31, 26 |
| 18 | State Street Corp | 1.64M (1.73%) | -16.38K Decreased by -1.00% | Mar 31, 25 |
| 19 | Bank of America Corp | 1.30M (1.37%) | 303.98K Increased by +23.43% | Mar 31, 26 |
| 20 | Aberdeen Group PLC | 1.21M (1.28%) | -176.36K Decreased by -14.54% | Mar 31, 26 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | SPDR® S&P Biotech ETF | 4.54M (4.78%) | 24.19K Increased by +0.53% | Mar 31, 24 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 2.73M (2.88%) | 0.00 Increased by 0.00% | Apr 30, 26 |
| 3 | ACATIS Datini Valueflex Fonds A | 2.00M (2.11%) | 0.00 Increased by 0.00% | Apr 30, 26 |
| 4 | Selectra J. Lamarck Biotech A | 1.46M (1.54%) | 0.00 Increased by 0.00% | May 31, 26 |
| 5 | Belfius Equities Cure C Cap | 1.15M (1.21%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 6 | Pictet-Biotech P USD | 1.09M (1.15%) | -241.00K Decreased by -22.12% | Jun 30, 23 |
| 7 | Vanguard Institutional Extnd Mkt Idx Tr | 959.91K (1.01%) | 34.89K Increased by +3.63% | Apr 30, 26 |
| 8 | Candriam Global Equities Oncology | 860.00K (0.91%) | 360.00K Increased by +41.86% | Dec 31, 23 |
| 9 | Fidelity Small Cap Index | 843.92K (0.89%) | 0.00 Increased by 0.00% | May 31, 25 |
| 10 | iShares Russell 2000 Value ETF | 762.12K (0.80%) | 0.00 Increased by 0.00% | May 31, 25 |
| 11 | Fidelity® Small Cap Index | 724.39K (0.76%) | 22.01K Increased by +3.04% | Oct 31, 23 |
| 12 | Pictet-Global Megatrend Sel I USD | 672.75K (0.71%) | 1.38K Increased by +0.20% | Dec 31, 23 |
| 13 | iShares Biotechnology ETF | 618.07K (0.65%) | 11.84K Increased by +1.92% | May 29, 26 |
| 14 | Direxion Daily S&P Biotech Bull 3X ETF | 541.45K (0.57%) | -3.80K Decreased by -0.70% | Mar 31, 24 |
| 15 | State St Russell Sm/Mid Cp® Indx NL Cl C | 478.79K (0.50%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 16 | State St Russell Sm/Mid Cp® Indx SL Cl I | 478.79K (0.50%) | 0.00 Increased by 0.00% | May 31, 25 |
| 17 | Fidelity Extended Market Index | 470.86K (0.50%) | -1.72K Decreased by -0.37% | Apr 30, 26 |
| 18 | abrdn Life Sciences Investors | 435.21K (0.46%) | -641.13K Decreased by -147.32% | May 31, 26 |
| 19 | Schwab US Small-Cap ETF™ | 425.17K (0.45%) | 279.00 Increased by +0.07% | May 30, 26 |
| 20 | Vanguard Russell 2000 ETF | 411.14K (0.43%) | 3.71K Increased by +0.90% | May 31, 25 |