| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 23.09M (14.35%) | 678.70K Increased by +2.94% | Dec 31, 25 |
| 2 | BlackRock Inc | 12.97M (8.07%) | 2.61M Increased by +20.08% | Dec 31, 25 |
| 3 | Vanguard Group Inc | 11.51M (7.16%) | 3.76M Increased by +32.63% | Dec 31, 25 |
| 4 | Paradigm Biocapital Advisors LP | 10.35M (6.44%) | 1.39M Increased by +13.42% | Jun 30, 25 |
| 5 | Deerfield Management Co | 9.04M (5.62%) | -9.21K Decreased by -0.10% | Dec 31, 25 |
| 6 | State Street Corporation | 7.63M (4.74%) | 3.48M Increased by +45.58% | Mar 31, 24 |
| 7 | RA Capital Management, LLC | 6.42M (3.99%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 8 | Kynam Capital Management, LP | 6.17M (3.83%) | -1.72M Decreased by -27.91% | Dec 31, 25 |
| 9 | Fairmount Funds Management LLC | 5.50M (3.42%) | -3.50M Decreased by -63.60% | Mar 31, 26 |
| 10 | RTW INVESTMENTS, LLC | 5.46M (3.39%) | -2.13M Decreased by -39.09% | Mar 31, 26 |
| 11 | TCG Crossover Management, LLC | 4.95M (3.08%) | -921.27K Decreased by -18.62% | Mar 31, 26 |
| 12 | State Street Corp | 4.94M (3.07%) | 164.88K Increased by +3.34% | Dec 31, 25 |
| 13 | Point72 Asset Management, L.P. | 4.91M (3.05%) | -383.62K Decreased by -7.81% | Jun 30, 25 |
| 14 | HHG PLC | 4.54M (2.82%) | 1.36M Increased by +29.96% | Dec 31, 25 |
| 15 | Adage Capital Partners Gp LLC | 4.30M (2.67%) | 233.97K Increased by +5.44% | Dec 31, 24 |
| 16 | Suvretta Capital Management, LLC | 3.71M (2.31%) | 657.24K Increased by +17.71% | Dec 31, 23 |
| 17 | UBS Group AG | 3.52M (2.19%) | 414.54K Increased by +11.78% | Jun 30, 25 |
| 18 | Geode Capital Management, LLC | 3.51M (2.18%) | 240.41K Increased by +6.84% | Dec 31, 25 |
| 19 | Vestal Point Capital LP | 3.08M (1.91%) | 80.00K Increased by +2.60% | Jun 30, 25 |
| 20 | COMMODORE CAPITAL LP | 2.89M (1.80%) | 691.16K Increased by +23.93% | Mar 31, 26 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 4.91M (3.05%) | 312.38K Increased by +6.36% | Mar 31, 26 |
| 2 | Vanguard Small Cap Index | 3.56M (2.21%) | 1.91M Increased by +53.51% | Mar 31, 26 |
| 3 | iShares Russell 2000 ETF | 3.37M (2.09%) | 28.39K Increased by +0.84% | Apr 30, 26 |
| 4 | Vanguard US Total Market Shares ETF | 3.09M (1.92%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 5 | State Street® SPDR® S&P® Biotech ETF | 2.63M (1.63%) | -18.65K Decreased by -0.71% | Apr 30, 26 |
| 6 | Fidelity Small Cap Growth | 2.51M (1.56%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 7 | Fidelity Select Health Care | 2.28M (1.42%) | -280.00K Decreased by -12.28% | Mar 31, 26 |
| 8 | Vanguard Small Cap Value Index Inv | 2.27M (1.41%) | 1.20M Increased by +53.05% | Mar 31, 26 |
| 9 | Fidelity OTC | 1.87M (1.16%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 10 | FIAM Small Cap Core Composite | 1.87M (1.16%) | 225.12K Increased by +12.06% | Mar 31, 25 |
| 11 | Fidelity Advisor Biotechnology I | 1.83M (1.14%) | -153.60K Decreased by -8.37% | Mar 31, 26 |
| 12 | FIAM Small Cap Core CIT Cl B | 1.83M (1.13%) | -15.60K Decreased by -0.85% | May 31, 25 |
| 13 | Vanguard Institutional Extnd Mkt Idx Tr | 1.72M (1.07%) | 43.21K Increased by +2.52% | Mar 31, 26 |
| 14 | Fidelity Select Biotechnology | 1.69M (1.05%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 15 | BlackRock Health Sciences Opps Inv A | 1.41M (0.87%) | 586.44K Increased by +41.68% | Mar 31, 26 |
| 16 | Fidelity Small Cap Index | 1.36M (0.85%) | 14.73K Increased by +1.08% | Feb 28, 26 |
| 17 | Strategic Advisers Fidelity US TtlStk | 1.28M (0.80%) | -20.00K Decreased by -1.56% | Mar 31, 26 |
| 18 | Lord Abbett & Co. Growth Equity- SA | 1.27M (0.79%) | 1.27M Increased by +100.00% | Mar 31, 26 |
| 19 | Lord Abbett Growth Leaders I | 1.27M (0.79%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 20 | Fidelity Small Cap Growth K6 | 1.25M (0.78%) | 0.00 Increased by 0.00% | Feb 28, 26 |