| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Wellington Management Company LLP | 8.08M (13.17%) | 2.28M Increased by +28.21% | Dec 31, 25 |
| 2 | Kynam Capital Management, LP | 5.94M (9.68%) | -157.55K Decreased by -2.65% | Dec 31, 25 |
| 3 | BlackRock Inc | 5.51M (8.97%) | -44.03K Decreased by -0.80% | Sep 30, 25 |
| 4 | FMR Inc | 4.91M (8.00%) | -54.62K Decreased by -1.11% | Dec 31, 25 |
| 5 | Vanguard Group Inc | 4.03M (6.56%) | 72.82K Increased by +1.81% | Dec 31, 25 |
| 6 | Bellevue Group AG | 3.62M (5.90%) | 60.00K Increased by +1.66% | Dec 31, 25 |
| 7 | RTW INVESTMENTS, LLC | 3.46M (5.64%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 8 | State Street Corporation | 2.98M (4.86%) | 602.42K Increased by +20.22% | Mar 31, 24 |
| 9 | State Street Corp | 2.84M (4.63%) | 436.64K Increased by +15.36% | Sep 30, 25 |
| 10 | COMMODORE CAPITAL LP | 2.56M (4.18%) | -463.33K Decreased by -18.06% | Dec 31, 25 |
| 11 | Jefferies Financial Group Inc | 2.39M (3.90%) | 2.37M Increased by +99.12% | Dec 31, 24 |
| 12 | T. Rowe Price Associates, Inc. | 2.38M (3.88%) | -1.44M Decreased by -60.24% | Sep 30, 25 |
| 13 | Deep Track Capital, LP | 1.90M (3.10%) | -99.26K Decreased by -5.22% | Dec 31, 25 |
| 14 | BRAIDWELL LP | 1.86M (3.03%) | 1.27M Increased by +68.16% | Dec 31, 25 |
| 15 | Point72 Asset Management, L.P. | 1.76M (2.87%) | -2.14M Decreased by -121.45% | Dec 31, 25 |
| 16 | T. Rowe Price Investment Management,Inc. | 1.70M (2.77%) | -37.02K Decreased by -2.18% | Dec 31, 24 |
| 17 | Eventide Asset Management, LLC | 1.64M (2.68%) | -216.54K Decreased by -13.18% | Dec 31, 25 |
| 18 | Geode Capital Management, LLC | 1.63M (2.65%) | -19.61K Decreased by -1.20% | Dec 31, 25 |
| 19 | Woodline Partners LP | 1.50M (2.45%) | 312.03K Increased by +20.80% | Jun 30, 25 |
| 20 | Eversept Partners, LP | 1.43M (2.34%) | 280.81K Increased by +19.57% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Health Care Inv | 4.25M (6.93%) | 2.05M Increased by +48.28% | Dec 31, 25 |
| 2 | BB Biotech AG Ord | 3.56M (5.80%) | 250.10K Increased by +7.03% | Sep 30, 25 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 2.13M (3.47%) | 8.38K Increased by +0.39% | Feb 28, 26 |
| 4 | Vanguard US Total Market Shares ETF | 2.07M (3.37%) | 2.12K Increased by +0.10% | Sep 30, 24 |
| 5 | iShares Russell 2000 ETF | 1.59M (2.59%) | -12.97K Decreased by -0.82% | Mar 31, 26 |
| 6 | State Street® SPDR® S&P® Biotech ETF | 1.28M (2.08%) | 75.22K Increased by +5.88% | Mar 31, 26 |
| 7 | Polar Capital Healthcare Opports Inc | 1.15M (1.87%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 8 | Fidelity Advisor® Biotechnology I | 1.07M (1.75%) | -257.15K Decreased by -23.94% | Nov 30, 23 |
| 9 | Vanguard Explorer Inv | 1.06M (1.72%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 10 | Eventide Healthcare & Life Sciences I | 1.04M (1.69%) | -319.19K Decreased by -30.78% | Dec 31, 25 |
| 11 | Polar Capital Biotech S Inc | 950.00K (1.55%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 12 | Fidelity Advisor Growth Opps M | 936.70K (1.53%) | 20.80K Increased by +2.22% | Mar 31, 24 |
| 13 | Fidelity Advisor® Growth Opps M | 915.90K (1.49%) | 111.90K Increased by +12.22% | Nov 30, 23 |
| 14 | Fidelity® Select Biotechnology | 907.20K (1.48%) | 184.00K Increased by +20.28% | Nov 30, 23 |
| 15 | SPDR® S&P Biotech ETF | 871.82K (1.42%) | 1.95K Increased by +0.22% | Aug 31, 25 |
| 16 | T. Rowe Price Integrated US SmCapGrEq | 851.45K (1.39%) | 567.31K Increased by +66.63% | Dec 31, 24 |
| 17 | Fidelity Contrafund | 767.20K (1.25%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 18 | Vanguard Institutional Extnd Mkt Idx Tr | 725.97K (1.18%) | 6.24K Increased by +0.86% | Feb 28, 26 |
| 19 | Pictet Biotech | 722.82K (1.18%) | 722.82K Increased by +100.00% | Mar 31, 24 |
| 20 | Pictet-Global Megatrend Sel I USD | 652.37K (1.06%) | -126.50K Decreased by -19.39% | Jan 31, 24 |