| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Darwin Global Management, Ltd. | 3.03M (16.35%) | 3.03M Increased by +100.00% | Dec 31, 25 |
| 2 | RTW INVESTMENTS, LLC | 715.33K (3.86%) | 402.83K Increased by +56.31% | Dec 31, 25 |
| 3 | Millennium Management LLC | 558.88K (3.02%) | 538.14K Increased by +96.29% | Dec 31, 25 |
| 4 | RA Capital Management, LLC | 432.48K (2.34%) | -442.52K Decreased by -102.32% | Dec 31, 25 |
| 5 | Eventide Asset Management, LLC | 383.09K (2.07%) | 187.78K Increased by +49.02% | Dec 31, 25 |
| 6 | Point72 Asset Management, L.P. | 284.44K (1.54%) | 281.34K Increased by +98.91% | Dec 31, 25 |
| 7 | Deerfield Management Co | 233.81K (1.26%) | 233.81K Increased by +100.00% | Dec 31, 25 |
| 8 | Marshall Wace Asset Management Ltd | 192.70K (1.04%) | 5.20K Increased by +2.70% | Dec 31, 25 |
| 9 | Armistice Capital, LLC | 167.93K (0.91%) | 167.93K Increased by +100.00% | Dec 31, 24 |
| 10 | MPM Oncology Impact Management LP | 87.76K (0.47%) | 87.76K Increased by +100.00% | Dec 31, 25 |
| 11 | Holocene Advisors, LP | 84.07K (0.45%) | 84.07K Increased by +100.00% | Dec 31, 25 |
| 12 | Alyeska Investment Group, L.P. | 83.62K (0.45%) | 83.62K Increased by +100.00% | Mar 31, 25 |
| 13 | Fred Alger Management, LLC | 79.39K (0.43%) | 79.39K Increased by +100.00% | Dec 31, 25 |
| 14 | Western Standard LLC | 60.03K (0.32%) | 60.03K Increased by +100.00% | Dec 31, 25 |
| 15 | Perceptive Advisors LLC | 49.79K (0.27%) | 49.79K Increased by +100.00% | Sep 30, 25 |
| 16 | The Goldman Sachs Group Inc | 44.60K (0.24%) | 40.89K Increased by +91.69% | Dec 31, 25 |
| 17 | Soleus Capital Management, L.P. | 40.35K (0.22%) | -169.65K Decreased by -420.39% | Dec 31, 25 |
| 18 | ADAR1 Capital Management LLC | 39.84K (0.22%) | 39.84K Increased by +100.00% | Dec 31, 25 |
| 19 | Jane Street Group LLC | 32.32K (0.17%) | 32.32K Increased by +100.00% | Dec 31, 25 |
| 20 | Squadron Capital Management LLC | 26.00K (0.14%) | 26.00K Increased by +100.00% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Eventide Healthcare & Life Sciences I | 383.09K (2.07%) | 187.78K Increased by +49.02% | Dec 31, 25 |
| 2 | MEDICAL BioHealth EUR Acc | 130.19K (0.70%) | -13.47K Decreased by -10.34% | Feb 28, 26 |
| 3 | HBM Healthcare Investments AG Ord | 90.00K (0.49%) | 90.00K Increased by +100.00% | Dec 31, 25 |
| 4 | Alger Small Cap Focus Composite | 51.65K (0.28%) | -5.58K Decreased by -10.79% | Jan 31, 26 |
| 5 | Alger Small Cap Focus I | 51.65K (0.28%) | -5.58K Decreased by -10.79% | Jan 31, 26 |
| 6 | apo Medical Opportunities R | 28.66K (0.15%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 7 | RIM Global Bioscience EUR | 16.60K (0.09%) | 7.00K Increased by +42.17% | Dec 31, 25 |
| 8 | State Street® SPDR® Portfolio EM ETF | 12.46K (0.07%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 9 | SPDR® Portfolio Emerging Markets ETF | 10.93K (0.06%) | 0.00 Increased by 0.00% | Aug 29, 25 |
| 10 | MS INVF Global Endurance Z USD Acc | 9.21K (0.05%) | 9.21K Increased by +100.00% | Dec 31, 25 |
| 11 | SPDR® S&P Emerging Markets Small Cap ETF | 7.32K (0.04%) | 0.00 Increased by 0.00% | Aug 29, 25 |
| 12 | Morgan Stanley Global Endurance R6 | 7.02K (0.04%) | 7.02K Increased by +100.00% | Dec 31, 25 |
| 13 | Fidelity Nasdaq Composite Index | 6.73K (0.04%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 14 | Alger LIfe Sciences Innovation Composite | 5.54K (0.03%) | -3.19K Decreased by -57.56% | Jan 31, 26 |
| 15 | Alger Health Sciences A | 4.54K (0.02%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 16 | Fidelity Nasdaq Composite ETF | 3.70K (0.02%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 17 | State Street® SPDR® S&P® China ETF | 3.19K (0.02%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 18 | EQ/T. Rowe Price Health Sciences IB | 3.00K (0.02%) | 2.84K Increased by +94.70% | Feb 28, 26 |
| 19 | Steward International Enhanced Index I | 2.44K (0.01%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 20 | Alger Small Cap Focus I US | 2.33K (0.01%) | 2.33K Increased by +100.00% | Dec 31, 25 |