| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Suvretta Capital Management, LLC | 10.29M (8.30%) | 4.67M Increased by +45.36% | Dec 31, 25 |
| 2 | BlackRock Inc | 7.87M (6.36%) | 339.62K Increased by +4.31% | Sep 30, 25 |
| 3 | HHG PLC | 6.77M (5.47%) | 1.72M Increased by +25.38% | Sep 30, 25 |
| 4 | Stifel Financial Corp | 6.61M (5.34%) | 3.84K Increased by +0.06% | Sep 30, 25 |
| 5 | Farallon Capital Management, L.L.C. | 4.81M (3.89%) | 385.00K Increased by +8.00% | Mar 31, 25 |
| 6 | Vanguard Group Inc | 4.40M (3.55%) | 1.52M Increased by +34.59% | Dec 31, 25 |
| 7 | State Street Corp | 4.26M (3.44%) | 720.12K Increased by +16.91% | Sep 30, 25 |
| 8 | State Street Corporation | 3.87M (3.12%) | -90.67K Decreased by -2.34% | Dec 31, 23 |
| 9 | RP Management, LLC | 2.94M (2.37%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 10 | Bellevue Group AG | 2.80M (2.26%) | 762.00K Increased by +27.19% | Jun 30, 25 |
| 11 | D. E. Shaw & Co LP | 2.69M (2.17%) | 1.43M Increased by +52.98% | Dec 31, 25 |
| 12 | FMR Inc | 2.68M (2.17%) | 255.33K Increased by +9.52% | Dec 31, 25 |
| 13 | JPMorgan Chase & Co | 2.67M (2.16%) | 98.87K Increased by +3.70% | Sep 30, 25 |
| 14 | Geode Capital Management, LLC | 2.39M (1.93%) | 332.07K Increased by +13.88% | Dec 31, 25 |
| 15 | Armistice Capital, LLC | 2.14M (1.72%) | 462.58K Increased by +21.66% | Jun 30, 25 |
| 16 | BNP Paribas Arbitrage, SA | 2.09M (1.69%) | 1.25M Increased by +59.71% | Dec 31, 25 |
| 17 | T. Rowe Price Associates, Inc. | 2.01M (1.62%) | -1.16M Decreased by -57.80% | Sep 30, 25 |
| 18 | Citadel Advisors Llc | 1.74M (1.41%) | 746.20K Increased by +42.79% | Dec 31, 25 |
| 19 | Schonfeld Strategic Advisors LLC | 1.61M (1.30%) | 1.57M Increased by +97.46% | Dec 31, 25 |
| 20 | Balyasny Asset Management LLC | 1.59M (1.28%) | 1.21M Increased by +76.06% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | State Street® SPDR® S&P® Biotech ETF | 3.48M (2.81%) | 19.32K Increased by +0.55% | Feb 28, 26 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 2.83M (2.29%) | -62.83K Decreased by -2.22% | Jul 31, 25 |
| 3 | BB Biotech AG Ord | 2.80M (2.26%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 4 | Vanguard US Total Market Shares ETF | 2.43M (1.96%) | 217.08K Increased by +8.93% | Sep 30, 24 |
| 5 | Fidelity® Select Biotechnology | 2.32M (1.88%) | 8.80K Increased by +0.38% | Oct 31, 23 |
| 6 | iShares Russell 2000 ETF | 2.28M (1.84%) | 2.28M Increased by +100.00% | Feb 28, 26 |
| 7 | Vanguard Small Cap Index | 2.11M (1.70%) | -14.23K Decreased by -0.68% | Jul 31, 25 |
| 8 | Fidelity Select Biotechnology | 1.97M (1.59%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 9 | Janus Henderson Glb Life Scn I2 USD | 1.86M (1.50%) | 1.86M Increased by +100.00% | Jan 31, 26 |
| 10 | SPDR® S&P Biotech ETF | 1.48M (1.19%) | 3.29K Increased by +0.22% | Aug 31, 25 |
| 11 | American Funds SMALLCAP World A | 1.42M (1.14%) | 286.21K Increased by +20.18% | Dec 31, 25 |
| 12 | Vanguard Small Cap Value Index Inv | 1.36M (1.10%) | 6.87K Increased by +0.50% | Jul 31, 25 |
| 13 | HBM Healthcare Investments AG Ord | 1.33M (1.07%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 14 | Vanguard Institutional Extnd Mkt Idx Tr | 1.24M (1.00%) | -3.48K Decreased by -0.28% | Jan 31, 26 |
| 15 | T. Rowe Price Health Sciences | 1.22M (0.98%) | 439.33K Increased by +36.15% | Jan 31, 26 |
| 16 | Simplify Health Care ETF | 1.04M (0.84%) | 0.00 Increased by 0.00% | Feb 27, 26 |
| 17 | Fidelity Small Cap Index | 919.45K (0.74%) | 10.33K Increased by +1.12% | Dec 31, 25 |
| 18 | Janus Henderson Triton D | 891.63K (0.72%) | -10.52K Decreased by -1.18% | Jun 30, 25 |
| 19 | Janus Henderson US SMID Cap Growth | 891.63K (0.72%) | -10.52K Decreased by -1.18% | Jun 30, 25 |
| 20 | Janus Henderson US SMID Cap Growth MA | 891.63K (0.72%) | 891.60K Increased by +100.00% | Jun 30, 25 |