| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BlackRock Inc | 22.10M (11.32%) | 1.18M Increased by +5.34% | Dec 31, 24 |
| 2 | Vanguard Group Inc | 21.89M (11.21%) | 1.58M Increased by +7.24% | Dec 31, 24 |
| 3 | State Street Corporation | 17.48M (8.95%) | 4.70M Increased by +26.89% | Mar 31, 24 |
| 4 | venBio Select Advisor LLC | 11.87M (6.08%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 5 | Baker Bros Advisors LP | 10.13M (5.19%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 6 | Kynam Capital Management, LP | 9.09M (4.65%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 7 | Deerfield Management Co | 8.14M (4.17%) | 8.64K Increased by +0.11% | Dec 31, 24 |
| 8 | State Street Corp | 7.50M (3.84%) | -1.35M Decreased by -18.01% | Dec 31, 24 |
| 9 | Alkeon Capital Management, LLC | 7.09M (3.63%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 10 | Millennium Management LLC | 4.98M (2.55%) | -318.81K Decreased by -6.40% | Sep 30, 23 |
| 11 | Geode Capital Management, LLC | 4.82M (2.47%) | -14.25K Decreased by -0.30% | Dec 31, 24 |
| 12 | Pictet Asset Manangement SA | 4.19M (2.15%) | 4.19M Increased by +100.00% | Sep 30, 23 |
| 13 | RP Management, LLC | 3.85M (1.97%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 14 | Nuveen Asset Management, LLC | 3.42M (1.75%) | -1.40M Decreased by -40.82% | Dec 31, 24 |
| 15 | BRAIDWELL LP | 3.38M (1.73%) | -1.98M Decreased by -58.69% | Mar 31, 24 |
| 16 | Fisher Asset Management, LLC | 3.18M (1.63%) | -155.44K Decreased by -4.88% | Dec 31, 24 |
| 17 | Morgan Stanley - Brokerage Accounts | 3.16M (1.62%) | -860.19K Decreased by -27.26% | Jun 30, 24 |
| 18 | Caligan Partners LP | 3.00M (1.53%) | 412.35K Increased by +13.76% | Dec 31, 24 |
| 19 | GW&K Investment Management, LLC | 2.94M (1.51%) | -336.20K Decreased by -11.43% | Dec 31, 24 |
| 20 | Point72 Asset Management, L.P. | 2.76M (1.41%) | -1.25M Decreased by -45.16% | Sep 30, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BioPharma Credit Ord | 17.26M (8.84%) | 17.26M Increased by +100.00% | Jun 30, 23 |
| 2 | Vanguard US Total Market Shares ETF | 6.57M (3.36%) | -18.55K Decreased by -0.28% | Sep 30, 24 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 6.55M (3.36%) | 30.47K Increased by +0.46% | Mar 31, 25 |
| 4 | iShares Russell 2000 ETF | 5.06M (2.59%) | 855.00 Increased by +0.02% | Apr 30, 25 |
| 5 | Vanguard Institutional Extnd Mkt Idx Tr | 3.22M (1.65%) | 89.76K Increased by +2.79% | Mar 31, 25 |
| 6 | SPDR® S&P Biotech ETF | 3.03M (1.55%) | -44.35K Decreased by -1.46% | Apr 30, 25 |
| 7 | Pictet-Biotech P USD | 2.79M (1.43%) | -13.26K Decreased by -0.47% | Jul 31, 23 |
| 8 | Vanguard Small Cap Index | 2.60M (1.33%) | -39.85K Decreased by -1.53% | Mar 31, 25 |
| 9 | Fidelity® Select Biotechnology | 2.58M (1.32%) | -225.50K Decreased by -8.74% | Nov 30, 23 |
| 10 | Fidelity Small Cap Index | 2.05M (1.05%) | 13.48K Increased by +0.66% | Feb 28, 25 |
| 11 | Eventide Healthcare & Life Sciences I | 1.97M (1.01%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 12 | Vanguard Strategic Equity Inv | 1.94M (0.99%) | 100.59K Increased by +5.20% | Mar 31, 25 |
| 13 | iShares Russell 2000 Growth ETF | 1.84M (0.94%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 14 | Fidelity® Small Cap Index | 1.82M (0.93%) | 49.54K Increased by +2.71% | Oct 31, 23 |
| 15 | Vanguard Explorer Inv | 1.76M (0.90%) | -30.65K Decreased by -1.74% | Mar 31, 25 |
| 16 | Pictet-Global Megatrend Sel I USD | 1.75M (0.90%) | 438.00 Increased by +0.02% | Jul 31, 23 |
| 17 | Vanguard Small Cap Growth Index Inv | 1.46M (0.75%) | -20.79K Decreased by -1.43% | Mar 31, 25 |
| 18 | BNP Paribas Health Cr Innovtr Cl Cap | 1.28M (0.66%) | -120.93K Decreased by -9.45% | Nov 30, 23 |
| 19 | iShares Biotechnology ETF | 1.24M (0.64%) | 2.84K Increased by +0.23% | Apr 30, 25 |
| 20 | Nuveen Quant Small Cap Equity Instl | 1.23M (0.63%) | 24.74K Increased by +2.02% | Feb 29, 24 |