| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BlackRock Inc | 22.77M (10.96%) | 674.08K Increased by +2.96% | Mar 31, 25 |
| 2 | Vanguard Group Inc | 21.66M (10.43%) | -230.66K Decreased by -1.06% | Mar 31, 25 |
| 3 | State Street Corporation | 17.48M (8.42%) | 4.70M Increased by +26.89% | Mar 31, 24 |
| 4 | Baker Bros Advisors LP | 10.13M (4.88%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 5 | Kynam Capital Management, LP | 8.93M (4.30%) | -156.84K Decreased by -1.76% | Mar 31, 25 |
| 6 | venBio Select Advisor LLC | 8.70M (4.19%) | -3.17M Decreased by -36.38% | Mar 31, 25 |
| 7 | State Street Corp | 7.81M (3.76%) | 314.44K Increased by +4.02% | Mar 31, 25 |
| 8 | Alkeon Capital Management, LLC | 7.21M (3.47%) | 120.20K Increased by +1.67% | Mar 31, 25 |
| 9 | Deerfield Management Co | 5.19M (2.50%) | -2.95M Decreased by -56.94% | Mar 31, 25 |
| 10 | Geode Capital Management, LLC | 4.96M (2.39%) | 136.90K Increased by +2.76% | Mar 31, 25 |
| 11 | Pictet Asset Manangement SA | 4.19M (2.02%) | 4.19M Increased by +100.00% | Sep 30, 23 |
| 12 | RP Management, LLC | 3.85M (1.85%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 13 | Millennium Management LLC | 3.81M (1.84%) | 3.02M Increased by +79.28% | Mar 31, 25 |
| 14 | Assenagon Asset Management SA | 3.62M (1.74%) | 3.61M Increased by +99.61% | Jun 30, 25 |
| 15 | Nuveen Asset Management, LLC | 3.42M (1.65%) | -1.40M Decreased by -40.82% | Dec 31, 24 |
| 16 | BRAIDWELL LP | 3.38M (1.63%) | -1.98M Decreased by -58.69% | Mar 31, 24 |
| 17 | Two Sigma Advisers, LLC | 3.22M (1.55%) | 720.90K Increased by +22.38% | Mar 31, 25 |
| 18 | Caligan Partners LP | 3.11M (1.50%) | 111.74K Increased by +3.60% | Mar 31, 25 |
| 19 | Fisher Asset Management, LLC | 3.05M (1.47%) | -130.48K Decreased by -4.28% | Mar 31, 25 |
| 20 | GW&K Investment Management, LLC | 2.88M (1.39%) | -56.72K Decreased by -1.97% | Mar 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BioPharma Credit Ord | 17.22M (8.29%) | 17.22M Increased by +100.00% | Dec 31, 24 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 6.73M (3.24%) | 31.73K Increased by +0.47% | Jun 30, 25 |
| 3 | Vanguard US Total Market Shares ETF | 6.57M (3.16%) | -18.55K Decreased by -0.28% | Sep 30, 24 |
| 4 | iShares Russell 2000 ETF | 5.03M (2.42%) | -81.26K Decreased by -1.62% | Jul 30, 25 |
| 5 | SPDR® S&P Biotech ETF | 3.66M (1.76%) | 90.09K Increased by +2.46% | Jul 31, 25 |
| 6 | ACAP Strategic A | 3.55M (1.71%) | 82.83K Increased by +2.34% | Mar 31, 25 |
| 7 | Vanguard Institutional Extnd Mkt Idx Tr | 3.24M (1.56%) | -13.77K Decreased by -0.43% | Jun 30, 25 |
| 8 | Pictet-Biotech P USD | 2.79M (1.35%) | -13.26K Decreased by -0.47% | Jul 31, 23 |
| 9 | Fidelity® Select Biotechnology | 2.58M (1.24%) | -225.50K Decreased by -8.74% | Nov 30, 23 |
| 10 | Vanguard Small Cap Index | 2.56M (1.23%) | -79.71K Decreased by -3.12% | Jun 30, 25 |
| 11 | Fidelity Small Cap Index | 2.09M (1.01%) | 3.50K Increased by +0.17% | May 31, 25 |
| 12 | Eventide Healthcare & Life Sciences I | 1.97M (0.95%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 13 | iShares Russell 2000 Growth ETF | 1.84M (0.89%) | -4.57K Decreased by -0.25% | Jul 30, 25 |
| 14 | Fidelity® Small Cap Index | 1.82M (0.88%) | 49.54K Increased by +2.71% | Oct 31, 23 |
| 15 | Pictet-Global Megatrend Sel I USD | 1.75M (0.84%) | 438.00 Increased by +0.02% | Jul 31, 23 |
| 16 | Vanguard Strategic Equity Inv | 1.74M (0.84%) | -199.07K Decreased by -11.47% | Jun 30, 25 |
| 17 | Vanguard Small Cap Growth Index Inv | 1.44M (0.69%) | -15.27K Decreased by -1.06% | Jun 30, 25 |
| 18 | BNP Paribas Health Cr Innovtr Cl Cap | 1.28M (0.62%) | -120.93K Decreased by -9.45% | Nov 30, 23 |
| 19 | CREF Stock R3 | 1.28M (0.62%) | 0.00 Increased by 0.00% | May 31, 25 |
| 20 | Nuveen Quant Small Cap Equity Instl | 1.23M (0.59%) | 24.74K Increased by +2.02% | Feb 29, 24 |