| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | HHG PLC | 14.08M (16.60%) | 753.33K Increased by +5.35% | Dec 31, 24 |
| 2 | RTW INVESTMENTS, LLC | 6.95M (8.19%) | -188.50K Decreased by -2.71% | Dec 31, 23 |
| 3 | Gendell Jeffrey L | 6.33M (7.46%) | 525.00K Increased by +8.29% | Dec 31, 24 |
| 4 | BlackRock Inc | 5.44M (6.41%) | 182.40K Increased by +3.35% | Dec 31, 24 |
| 5 | Polar Capital Holdings PLC | 4.41M (5.20%) | -419.83K Decreased by -9.51% | Dec 31, 24 |
| 6 | Two Seas Capital LP | 4.30M (5.07%) | 2.04M Increased by +47.54% | Dec 31, 24 |
| 7 | BRAIDWELL LP | 4.11M (4.84%) | 716.79K Increased by +17.46% | Dec 31, 24 |
| 8 | Vanguard Group Inc | 3.95M (4.66%) | 90.15K Increased by +2.28% | Dec 31, 24 |
| 9 | Vivo Capital, LLC | 2.68M (3.16%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 10 | Citadel Advisors Llc | 2.59M (3.06%) | 234.99K Increased by +9.06% | Dec 31, 24 |
| 11 | WEALTH EFFECTS LLC | 2.37M (2.79%) | 24.99K Increased by +1.05% | Mar 31, 25 |
| 12 | Brandes Investment Partners & Co | 2.17M (2.56%) | 798.41K Increased by +36.74% | Dec 31, 24 |
| 13 | Goldman Sachs Group Inc | 2.15M (2.53%) | 286.22K Increased by +13.34% | Dec 31, 24 |
| 14 | Tri Locum Partners LP | 1.94M (2.29%) | 277.03K Increased by +14.29% | Dec 31, 24 |
| 15 | Woodline Partners LP | 1.69M (1.99%) | 182.78K Increased by +10.83% | Sep 30, 24 |
| 16 | State Street Corp | 1.69M (1.99%) | 62.84K Increased by +3.73% | Dec 31, 24 |
| 17 | COWEN AND COMPANY, LLC | 1.64M (1.94%) | -695.96K Decreased by -42.38% | Dec 31, 23 |
| 18 | UBS Group AG | 1.57M (1.85%) | 963.56K Increased by +61.34% | Dec 31, 24 |
| 19 | TANG CAPITAL MANAGEMENT LLC | 1.50M (1.77%) | 267.50K Increased by +17.86% | Dec 31, 24 |
| 20 | Millennium Management LLC | 1.21M (1.43%) | 233.99K Increased by +19.31% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Polar Capital Healthcare Opports Inc | 3.62M (4.26%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 2 | Vanguard US Total Market Shares ETF | 2.99M (3.52%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 2.84M (3.34%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 4 | Janus Henderson Global Life Sciences | 2.54M (3.00%) | -131.86K Decreased by -5.19% | Dec 31, 24 |
| 5 | Janus Henderson Global Life Sciences D | 2.49M (2.94%) | -16.69K Decreased by -0.67% | Feb 28, 25 |
| 6 | iShares Russell 2000 ETF | 2.29M (2.70%) | 387.00 Increased by +0.02% | Apr 30, 25 |
| 7 | Janus Selection Global Life Science AUSD | 2.12M (2.49%) | -94.87K Decreased by -4.48% | Jun 30, 24 |
| 8 | Janus Global Life Science AUSD | 2.03M (2.40%) | 39.47K Increased by +1.94% | Dec 31, 24 |
| 9 | Janus Henderson Glb Life Scn I2 USD | 2.02M (2.38%) | -4.84K Decreased by -0.24% | Mar 31, 25 |
| 10 | Polar Capital Biotech S Inc | 1.50M (1.77%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 11 | Janus Henderson US Small Cap Growth | 1.48M (1.74%) | 313.10K Increased by +21.16% | Dec 31, 24 |
| 12 | Janus Henderson US Small Cap Growth MA | 1.48M (1.74%) | 1.48M Increased by +99.99% | Dec 31, 24 |
| 13 | Janus Henderson Venture D | 1.48M (1.74%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 14 | Janus Henderson Hrzn Biotec E2 USD | 1.05M (1.24%) | 111.59K Increased by +10.61% | Mar 31, 25 |
| 15 | Fidelity Small Cap Index | 923.29K (1.09%) | 1.73K Increased by +0.19% | Feb 28, 25 |
| 16 | Brandes International Small Cap Equity A | 854.55K (1.01%) | 282.57K Increased by +33.07% | Mar 31, 25 |
| 17 | MEDICAL BioHealth EUR Acc | 848.94K (1.00%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 18 | iShares Russell 2000 Growth ETF | 814.90K (0.96%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 19 | Brandes European Value I USD | 781.44K (0.92%) | 7.66K Increased by +0.98% | Mar 31, 25 |
| 20 | Brandes International Small Cap Eq | 597.11K (0.70%) | 327.91K Increased by +54.92% | Mar 31, 25 |