| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | HHG PLC | 13.59M (16.89%) | -487.88K Decreased by -3.59% | Mar 31, 25 |
| 2 | RTW INVESTMENTS, LLC | 6.95M (8.63%) | -188.50K Decreased by -2.71% | Dec 31, 23 |
| 3 | Gendell Jeffrey L | 6.13M (7.61%) | -203.28K Decreased by -3.32% | Mar 31, 25 |
| 4 | Brandes Investment Partners & Co | 5.67M (7.04%) | 3.49M Increased by +61.65% | Mar 31, 25 |
| 5 | BlackRock Inc | 5.45M (6.78%) | 14.12K Increased by +0.26% | Mar 31, 25 |
| 6 | Two Seas Capital LP | 4.95M (6.15%) | 650.00K Increased by +13.14% | Mar 31, 25 |
| 7 | Polar Capital Holdings PLC | 4.36M (5.41%) | -58.24K Decreased by -1.34% | Mar 31, 25 |
| 8 | BRAIDWELL LP | 4.11M (5.10%) | 716.79K Increased by +17.46% | Dec 31, 24 |
| 9 | Vanguard Group Inc | 3.90M (4.85%) | -48.60K Decreased by -1.24% | Mar 31, 25 |
| 10 | Vivo Capital, LLC | 2.68M (3.33%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 11 | WEALTH EFFECTS LLC | 2.35M (2.93%) | -14.30K Decreased by -0.61% | Jun 30, 25 |
| 12 | Citadel Advisors Llc | 2.25M (2.79%) | -348.53K Decreased by -15.52% | Mar 31, 25 |
| 13 | Goldman Sachs Group Inc | 2.15M (2.67%) | 286.22K Increased by +13.34% | Dec 31, 24 |
| 14 | TANG CAPITAL MANAGEMENT LLC | 2.10M (2.61%) | 600.00K Increased by +28.61% | Mar 31, 25 |
| 15 | Tri Locum Partners LP | 1.94M (2.41%) | 277.03K Increased by +14.29% | Dec 31, 24 |
| 16 | State Street Corp | 1.66M (2.06%) | -26.83K Decreased by -1.62% | Mar 31, 25 |
| 17 | COWEN AND COMPANY, LLC | 1.64M (2.04%) | -695.96K Decreased by -42.38% | Dec 31, 23 |
| 18 | UBS Group AG | 1.29M (1.61%) | -276.23K Decreased by -21.34% | Mar 31, 25 |
| 19 | Millennium Management LLC | 1.21M (1.51%) | 233.99K Increased by +19.31% | Dec 31, 24 |
| 20 | Geode Capital Management, LLC | 1.19M (1.48%) | 24.34K Increased by +2.05% | Mar 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Polar Capital Healthcare Opports Inc | 3.69M (4.58%) | 70.00K Increased by +1.90% | Jun 30, 25 |
| 2 | Vanguard US Total Market Shares ETF | 2.99M (3.71%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 2.94M (3.65%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 4 | Janus Henderson Global Life Sciences D | 2.45M (3.05%) | -13.90K Decreased by -0.57% | May 31, 25 |
| 5 | Janus Henderson Global Life Sciences | 2.27M (2.82%) | -207.97K Decreased by -9.15% | Jun 30, 25 |
| 6 | iShares Russell 2000 ETF | 2.14M (2.66%) | -34.58K Decreased by -1.62% | Jul 30, 25 |
| 7 | Janus Selection Global Life Science AUSD | 2.12M (2.63%) | -94.87K Decreased by -4.48% | Jun 30, 24 |
| 8 | Janus Global Life Science AUSD | 2.02M (2.51%) | -16.05K Decreased by -0.80% | Mar 31, 25 |
| 9 | Janus Henderson Glb Life Scn I2 USD | 1.88M (2.34%) | -104.73K Decreased by -5.57% | Jun 30, 25 |
| 10 | Vanguard Institutional Extnd Mkt Idx Tr | 1.51M (1.87%) | 1.51M Increased by +100.00% | Jun 30, 25 |
| 11 | Polar Capital Biotech S Inc | 1.50M (1.86%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 12 | Janus Henderson US Small Cap Growth | 1.48M (1.84%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 13 | Janus Henderson Venture D | 1.48M (1.84%) | 0.00 Increased by 0.00% | May 31, 25 |
| 14 | Janus Henderson US Small Cap Growth MA | 1.48M (1.84%) | 1.48M Increased by +99.99% | Dec 31, 24 |
| 15 | Brandes International Small Cap Equity A | 1.40M (1.74%) | 232.59K Increased by +16.57% | Jun 30, 25 |
| 16 | Brandes European Value I USD | 1.06M (1.31%) | -4.00 Decreased by -0.00% | Jun 30, 25 |
| 17 | Fidelity Small Cap Index | 939.28K (1.17%) | -1.70K Decreased by -0.18% | May 31, 25 |
| 18 | MEDICAL BioHealth EUR Acc | 848.94K (1.05%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 19 | iShares Russell 2000 Growth ETF | 787.96K (0.98%) | -1.96K Decreased by -0.25% | Jul 30, 25 |
| 20 | Janus Henderson Hrzn Biotec E2 USD | 714.72K (0.89%) | -336.68K Decreased by -47.11% | Jun 30, 25 |