| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Suvretta Capital Management, LLC | 11.54M (12.76%) | 112.60K Increased by +0.98% | Jun 30, 25 |
| 2 | Jennison Associates LLC | 11.11M (12.29%) | -251.47K Decreased by -2.26% | Jun 30, 25 |
| 3 | Rubric Capital Management LP | 10.75M (11.89%) | -217.22K Decreased by -2.02% | Jun 30, 25 |
| 4 | State Street Corporation | 8.78M (9.71%) | 7.26M Increased by +82.64% | Mar 31, 24 |
| 5 | BlackRock Inc | 8.53M (9.44%) | -359.58K Decreased by -4.21% | Jun 30, 25 |
| 6 | FMR Inc | 8.26M (9.14%) | -950.74K Decreased by -11.51% | Sep 30, 23 |
| 7 | Vanguard Group Inc | 7.05M (7.80%) | 231.02K Increased by +3.28% | Jun 30, 25 |
| 8 | Polar Capital Holdings PLC | 5.01M (5.54%) | -1.70M Decreased by -33.96% | Jun 30, 25 |
| 9 | State Street Corp | 4.53M (5.01%) | 52.73K Increased by +1.16% | Jun 30, 25 |
| 10 | Morgan Stanley - Brokerage Accounts | 4.31M (4.77%) | 475.99K Increased by +11.03% | Jun 30, 25 |
| 11 | Gilder Gagnon Howe & CO LLC | 4.16M (4.60%) | 59.71K Increased by +1.44% | Jun 30, 25 |
| 12 | Citadel Advisors Llc | 3.03M (3.35%) | 98.43K Increased by +3.25% | Sep 30, 24 |
| 13 | UBS Group AG | 2.94M (3.25%) | 17.93K Increased by +0.61% | Jun 30, 25 |
| 14 | Franklin Resources Inc | 2.73M (3.02%) | -28.99K Decreased by -1.06% | Jun 30, 25 |
| 15 | Vestal Point Capital LP | 2.70M (2.99%) | 2.70M Increased by +100.00% | Dec 31, 23 |
| 16 | JPMorgan Chase & Co | 2.59M (2.87%) | 23.67K Increased by +0.91% | Sep 30, 24 |
| 17 | Geode Capital Management, LLC | 2.58M (2.86%) | 35.62K Increased by +1.38% | Jun 30, 25 |
| 18 | Marshall Wace Asset Management Ltd | 2.31M (2.56%) | -6.46K Decreased by -0.28% | Sep 30, 23 |
| 19 | Millennium Management LLC | 2.31M (2.55%) | 1.16M Increased by +50.33% | Dec 31, 24 |
| 20 | HHG PLC | 2.26M (2.50%) | 2.21M Increased by +97.68% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Polar Capital Biotech S Inc | 5.00M (5.53%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 2 | Vanguard US Total Market Shares ETF | 3.59M (3.97%) | 492.10K Increased by +13.71% | Sep 30, 24 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 3.39M (3.75%) | -71.75K Decreased by -2.12% | Jul 31, 25 |
| 4 | Jennison SMid Cap Core Equity | 3.17M (3.50%) | 83.01K Increased by +2.62% | Jun 30, 25 |
| 5 | PGIM Jennison Small Company A | 3.17M (3.50%) | 9.07K Increased by +0.29% | Jul 31, 25 |
| 6 | iShares Russell 2000 ETF | 2.58M (2.85%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 7 | Jennison Health Sciences Equity | 2.27M (2.51%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 8 | PGIM Jennison Health Sciences Z | 2.27M (2.51%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 9 | SPDR® S&P Biotech ETF | 1.88M (2.08%) | 4.20K Increased by +0.22% | Aug 31, 25 |
| 10 | Franklin Biotechnology Discv A(acc)USD | 1.61M (1.78%) | -77.76K Decreased by -4.84% | Aug 31, 25 |
| 11 | MEDICAL BioHealth EUR Acc | 1.40M (1.55%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 12 | American Century Small Cap Growth Inv | 1.33M (1.48%) | 50.43K Increased by +3.78% | Jun 30, 25 |
| 13 | American Century U.S. Small Cap Growth | 1.33M (1.48%) | 50.43K Increased by +3.78% | Jun 30, 25 |
| 14 | APO Medical Opportunities R | 1.18M (1.30%) | 220.59K Increased by +18.76% | Jul 31, 25 |
| 15 | Vanguard Institutional Extnd Mkt Idx Tr | 1.15M (1.28%) | -506.10K Decreased by -43.88% | Jul 31, 25 |
| 16 | Fidelity Small Cap Index | 1.08M (1.19%) | -15.43K Decreased by -1.44% | Jun 30, 25 |
| 17 | Fidelity Select Health Care | 945.94K (1.05%) | -54.06K Decreased by -5.71% | Nov 30, 23 |
| 18 | iShares Russell 2000 Growth ETF | 940.75K (1.04%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 19 | Franklin Biotechnology Discovery A | 904.89K (1.00%) | -60.66K Decreased by -6.70% | Jul 31, 25 |
| 20 | Fidelity OTC | 832.19K (0.92%) | 0.00 Increased by 0.00% | Dec 31, 23 |