| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Jennison Associates LLC | 9.07M (12.1%) | 4.63M Increased by +51.11% | Dec 31, 23 |
| 2 | Suvretta Capital Management, LLC | 8.47M (11.31%) | 7.34M Increased by +86.6% | Dec 31, 23 |
| 3 | FMR Inc | 8.26M (11.03%) | -950.74K Decreased by -11.51% | Sep 30, 23 |
| 4 | Rubric Capital Management LP | 5.03M (6.72%) | 150K Increased by +2.98% | Sep 30, 23 |
| 5 | Franklin Resources Inc | 4.66M (6.22%) | 3.36M Increased by +72.24% | Dec 31, 23 |
| 6 | State Street Corporation | 4.36M (5.82%) | -865.2K Decreased by -19.84% | Sep 30, 23 |
| 7 | BlackRock Inc | 4.02M (5.37%) | -210.97K Decreased by -5.25% | Sep 30, 23 |
| 8 | Polar Capital Holdings PLC | 3.12M (4.16%) | -9.83K Decreased by -0.32% | Sep 30, 23 |
| 9 | Bain Capital Life Sciences Investors, LLC | 3M (4.01%) | 0 Increased by 0% | Dec 31, 23 |
| 10 | Vanguard Group Inc | 2.88M (3.84%) | 229.07K Increased by +7.96% | Sep 30, 23 |
| 11 | Marshall Wace Asset Management Ltd | 2.31M (3.09%) | -6.46K Decreased by -0.28% | Sep 30, 23 |
| 12 | GW&K Investment Management, LLC | 2.07M (2.76%) | 6.61K Increased by +0.32% | Sep 30, 23 |
| 13 | Ensign Peak Advisors Inc | 2.03M (2.71%) | 1.2M Increased by +59.3% | Dec 31, 23 |
| 14 | Opaleye Management Inc | 1.96M (2.62%) | 1.96M Increased by +100% | Dec 31, 23 |
| 15 | Orbimed Advisors, LLC | 1.91M (2.56%) | 0 Increased by 0% | Sep 30, 23 |
| 16 | Holocene Advisors, LP | 1.2M (1.61%) | -235.5K Decreased by -19.55% | Sep 30, 23 |
| 17 | Pivotal bioVenture Partners Investment Advisor LLC | 1.11M (1.48%) | 0 Increased by 0% | Sep 30, 23 |
| 18 | Woodline Partners LP | 1.1M (1.47%) | 296.49K Increased by +26.85% | Sep 30, 23 |
| 19 | Geode Capital Management, LLC | 1.04M (1.39%) | 100.5K Increased by +9.68% | Sep 30, 23 |
| 20 | Two Sigma Investments LLC | 978.8K (1.31%) | 978.8K Increased by +100% | Dec 31, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Polar Capital Biotech S Inc | 5.5M (7.34%) | 109.88K Increased by +2% | Dec 31, 23 |
| 2 | Jennison Health Sciences Equity | 3.39M (4.53%) | 1.84M Increased by +54.41% | Dec 31, 23 |
| 3 | PGIM Jennison Health Sciences Z | 3.39M (4.53%) | 0 Increased by 0% | Jan 31, 24 |
| 4 | Franklin Biotechnology Discv A(acc)USD | 3.19M (4.26%) | 0 Increased by 0% | Jan 31, 24 |
| 5 | Vanguard Total Stock Mkt Idx Inv | 2.5M (3.34%) | 0 Increased by 0% | Jan 31, 24 |
| 6 | iShares Russell 2000 ETF | 1.92M (2.56%) | -35K Decreased by -1.82% | Jan 31, 24 |
| 7 | Franklin Biotechnology Discovery A | 1.54M (2.06%) | 76.71K Increased by +4.98% | Jan 31, 24 |
| 8 | Vanguard Institutional Extnd Mkt Idx Tr | 1.3M (1.74%) | -249.04K Decreased by -19.1% | Jan 31, 24 |
| 9 | Fidelity Select Health Care | 945.94K (1.26%) | -54.06K Decreased by -5.71% | Nov 30, 23 |
| 10 | American Century Small Cap Growth Inv | 850.88K (1.14%) | 386.06K Increased by +45.37% | Dec 31, 23 |
| 11 | American Century U.S. Small Cap Growth | 850.88K (1.14%) | 386.06K Increased by +45.37% | Dec 31, 23 |
| 12 | Fidelity OTC | 832.19K (1.11%) | 0 Increased by 0% | Dec 31, 23 |
| 13 | Fidelity® OTC | 832.19K (1.11%) | 0 Increased by 0% | Nov 30, 23 |
| 14 | PGIM Jennison Small Company A | 783.7K (1.05%) | 5.5K Increased by +0.7% | Jan 31, 24 |
| 15 | Jennison SMid Cap Core Equity | 778.2K (1.04%) | 0 Increased by 0% | Dec 31, 23 |
| 16 | Pictet-Biotech P USD | 710.41K (0.95%) | -196.74K Decreased by -27.69% | Jun 30, 23 |
| 17 | Columbia Small Cap Value I A | 706.76K (0.94%) | 4.9K Increased by +0.69% | Jan 31, 24 |
| 18 | Columbia Small Cap Value I | 701.86K (0.94%) | 8.2K Increased by +1.17% | Dec 31, 23 |
| 19 | iShares Russell 2000 Growth ETF | 691.35K (0.92%) | 810 Increased by +0.12% | Jan 31, 24 |
| 20 | Fidelity Advisor Health Care I | 656.8K (0.88%) | -33.2K Decreased by -5.05% | Nov 30, 23 |