| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Suvretta Capital Management, LLC | 11.40M (13.28%) | 677.63K Increased by +5.94% | Dec 31, 24 |
| 2 | Jennison Associates LLC | 11.36M (13.24%) | -978.92K Decreased by -8.62% | Mar 31, 25 |
| 3 | Rubric Capital Management LP | 10.97M (12.78%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 4 | BlackRock Inc | 9.15M (10.66%) | 119.00K Increased by +1.30% | Dec 31, 24 |
| 5 | State Street Corporation | 8.78M (10.24%) | 7.26M Increased by +82.64% | Mar 31, 24 |
| 6 | FMR Inc | 8.26M (9.63%) | -950.74K Decreased by -11.51% | Sep 30, 23 |
| 7 | Polar Capital Holdings PLC | 7.38M (8.60%) | 493.01K Increased by +6.68% | Dec 31, 24 |
| 8 | Vanguard Group Inc | 6.44M (7.51%) | -521.92K Decreased by -8.10% | Dec 31, 24 |
| 9 | State Street Corp | 4.95M (5.77%) | -690.91K Decreased by -13.96% | Dec 31, 24 |
| 10 | Morgan Stanley - Brokerage Accounts | 4.24M (4.95%) | 462.72K Increased by +10.90% | Dec 31, 24 |
| 11 | Gilder Gagnon Howe & CO LLC | 3.90M (4.55%) | 349.15K Increased by +8.95% | Dec 31, 24 |
| 12 | Franklin Resources Inc | 3.31M (3.86%) | -941.10K Decreased by -28.44% | Dec 31, 24 |
| 13 | Citadel Advisors Llc | 3.03M (3.53%) | 98.43K Increased by +3.25% | Sep 30, 24 |
| 14 | UBS Group AG | 2.79M (3.25%) | 2.57M Increased by +92.11% | Dec 31, 24 |
| 15 | Vestal Point Capital LP | 2.70M (3.15%) | 2.70M Increased by +100.00% | Dec 31, 23 |
| 16 | JPMorgan Chase & Co | 2.59M (3.02%) | 23.67K Increased by +0.91% | Sep 30, 24 |
| 17 | D. E. Shaw & Co LP | 2.51M (2.93%) | 768.55K Increased by +30.58% | Dec 31, 24 |
| 18 | Geode Capital Management, LLC | 2.47M (2.88%) | 2.59K Increased by +0.10% | Dec 31, 24 |
| 19 | Ensign Peak Advisors Inc | 2.37M (2.77%) | -42.67K Decreased by -1.80% | Dec 31, 24 |
| 20 | Marshall Wace Asset Management Ltd | 2.31M (2.69%) | -6.46K Decreased by -0.28% | Sep 30, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Polar Capital Biotech S Inc | 6.00M (6.99%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 2 | Vanguard US Total Market Shares ETF | 3.59M (4.18%) | 492.10K Increased by +13.71% | Sep 30, 24 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 3.34M (3.90%) | 37.27K Increased by +1.12% | Mar 31, 25 |
| 4 | Jennison SMid Cap Core Equity | 3.09M (3.60%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 5 | PGIM Jennison Small Company A | 3.09M (3.60%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 6 | iShares Russell 2000 ETF | 2.65M (3.09%) | 448.00 Increased by +0.02% | Apr 30, 25 |
| 7 | Jennison Health Sciences Equity | 2.27M (2.64%) | -465.50K Decreased by -20.51% | Mar 31, 25 |
| 8 | PGIM Jennison Health Sciences Z | 2.27M (2.64%) | -255.31K Decreased by -11.25% | Mar 31, 25 |
| 9 | SPDR® S&P Biotech ETF | 1.92M (2.23%) | -28.08K Decreased by -1.46% | Apr 30, 25 |
| 10 | Franklin Biotechnology Discv A(acc)USD | 1.71M (1.99%) | -112.50K Decreased by -6.58% | Mar 31, 25 |
| 11 | Vanguard Institutional Extnd Mkt Idx Tr | 1.64M (1.91%) | 46.51K Increased by +2.84% | Mar 31, 25 |
| 12 | MEDICAL BioHealth EUR Acc | 1.59M (1.85%) | 60.00K Increased by +3.78% | Jan 31, 25 |
| 13 | American Century Small Cap Growth Inv | 1.28M (1.50%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 14 | American Century U.S. Small Cap Growth | 1.28M (1.50%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 15 | Fidelity Small Cap Index | 1.07M (1.25%) | 9.71K Increased by +0.91% | Feb 28, 25 |
| 16 | Candriam Eqs L Biotech C USD Cap | 1.04M (1.21%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 17 | Franklin Biotechnology Discovery A | 982.75K (1.15%) | -72.29K Decreased by -7.36% | Mar 31, 25 |
| 18 | iShares Russell 2000 Growth ETF | 953.71K (1.11%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 19 | Fidelity Select Health Care | 945.94K (1.10%) | -54.06K Decreased by -5.71% | Nov 30, 23 |
| 20 | JENNISON SMALL/MID CAP EQUITY 3 | 923.56K (1.08%) | 31.00K Increased by +3.36% | Mar 31, 25 |