| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BlackRock Inc | 21.14M (9.56%) | 315.52K Increased by +1.49% | Dec 31, 25 |
| 2 | Vanguard Group Inc | 18.98M (8.58%) | 610.16K Increased by +3.21% | Dec 31, 25 |
| 3 | HHG PLC | 14.51M (6.56%) | 690.60K Increased by +4.76% | Dec 31, 25 |
| 4 | State Street Corporation | 14.09M (6.37%) | -3.01M Decreased by -21.39% | Mar 31, 24 |
| 5 | State Street Corp | 11.91M (5.39%) | 2.19M Increased by +18.41% | Dec 31, 25 |
| 6 | Millennium Management LLC | 11.91M (5.38%) | 4.27M Increased by +35.83% | Dec 31, 25 |
| 7 | Macquarie Group Ltd | 10.46M (4.73%) | -1.00M Decreased by -9.58% | Sep 30, 25 |
| 8 | Delaware Management Holdings Inc | 9.33M (4.22%) | 9.33M Increased by +100.00% | Dec 31, 25 |
| 9 | Geode Capital Management, LLC | 5.83M (2.63%) | 70.83K Increased by +1.22% | Dec 31, 25 |
| 10 | Eventide Asset Management, LLC | 5.60M (2.53%) | -1.81M Decreased by -32.36% | Dec 31, 24 |
| 11 | Marshall Wace Asset Management Ltd | 5.19M (2.35%) | -3.75M Decreased by -72.36% | Dec 31, 25 |
| 12 | Nuveen, LLC | 5.16M (2.33%) | -10.40K Decreased by -0.20% | Dec 31, 25 |
| 13 | Goldman Sachs Group Inc | 4.00M (1.81%) | 1.62M Increased by +40.58% | Jun 30, 25 |
| 14 | The Goldman Sachs Group Inc | 3.06M (1.39%) | 479.87K Increased by +15.66% | Dec 31, 25 |
| 15 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 2.89M (1.30%) | -414.88K Decreased by -14.37% | Jun 30, 24 |
| 16 | Two Sigma Investments LLC | 2.87M (1.30%) | 383.12K Increased by +13.33% | Dec 31, 25 |
| 17 | Adage Capital Partners Gp LLC | 2.60M (1.18%) | 300.00K Increased by +11.54% | Dec 31, 23 |
| 18 | D. E. Shaw & Co LP | 2.46M (1.11%) | 542.14K Increased by +22.05% | Jun 30, 25 |
| 19 | Morgan Stanley - Brokerage Accounts | 2.36M (1.07%) | -526.53K Decreased by -22.32% | Dec 31, 25 |
| 20 | Amvescap Plc. | 2.33M (1.05%) | 970.15K Increased by +41.58% | Dec 31, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Macquarie Small Cap Core I | 8.61M (3.89%) | -646.97K Decreased by -7.51% | Jul 31, 25 |
| 2 | State Street® SPDR® S&P® Biotech ETF | 8.57M (3.87%) | -60.84K Decreased by -0.71% | Apr 30, 26 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 7.40M (3.35%) | 115.50K Increased by +1.56% | Mar 31, 26 |
| 4 | Delaware Small Cap Core I | 7.32M (3.31%) | 0.00 Increased by 0.00% | Oct 31, 24 |
| 5 | Vanguard US Total Market Shares ETF | 7.03M (3.18%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 6 | Nomura Small Cap Core I | 6.47M (2.93%) | -205.98K Decreased by -3.18% | Mar 31, 26 |
| 7 | Nomura US Small Cap Core Equity | 6.47M (2.93%) | 6.47M Increased by +100.00% | Mar 31, 26 |
| 8 | iShares Russell 2000 ETF | 5.63M (2.54%) | 47.47K Increased by +0.84% | Apr 30, 26 |
| 9 | SPDR® S&P Biotech ETF | 4.38M (1.98%) | 9.78K Increased by +0.22% | Aug 31, 25 |
| 10 | Janus Selection Global Life Science AUSD | 3.62M (1.64%) | -114.93K Decreased by -3.17% | Mar 31, 24 |
| 11 | Janus Henderson Global Life Sciences D | 3.10M (1.40%) | -8.70K Decreased by -0.28% | Jan 31, 26 |
| 12 | Delaware US Small Cap Core Equity (SMA) | 3.06M (1.38%) | 3.06M Increased by +100.00% | Mar 31, 24 |
| 13 | Macquarie US Small Cap Core Equity | 3.06M (1.38%) | 3.06M Increased by +100.00% | Mar 31, 24 |
| 14 | Eventide Healthcare & Life Sciences I | 3.02M (1.36%) | -1.82M Decreased by -60.24% | Dec 31, 24 |
| 15 | T. Rowe Price Health Sciences | 2.95M (1.33%) | 1.26M Increased by +42.86% | Mar 31, 24 |
| 16 | Vanguard Institutional Extnd Mkt Idx Tr | 2.72M (1.23%) | 64.46K Increased by +2.37% | Mar 31, 26 |
| 17 | Janus Henderson Global Life Sciences | 2.60M (1.17%) | -514.32K Decreased by -19.82% | Mar 31, 26 |
| 18 | Eventide Gilead N | 2.57M (1.16%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 19 | Janus Henderson US SMID Cap Growth MA | 2.49M (1.13%) | 2.49M Increased by +99.99% | Dec 31, 24 |
| 20 | Janus Henderson Triton D | 2.45M (1.11%) | 0.00 Increased by 0.00% | May 31, 25 |