| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 10.22M (7.82%) | -858.69K Decreased by -8.40% | Dec 31, 25 |
| 2 | Redmile Group, LLC | 10.05M (7.69%) | 3.75M Increased by +37.31% | Dec 31, 25 |
| 3 | Bvf Inc | 9.13M (6.98%) | 2.13M Increased by +23.31% | Dec 31, 25 |
| 4 | BlackRock Inc | 7.90M (6.04%) | -63.36K Decreased by -0.80% | Sep 30, 25 |
| 5 | Vanguard Group Inc | 7.75M (5.93%) | 1.92M Increased by +24.74% | Dec 31, 25 |
| 6 | SATTER MANAGEMENT CO., L.P. | 7.41M (5.67%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 7 | Point72 Asset Management, L.P. | 5.63M (4.30%) | 299.80K Increased by +5.33% | Dec 31, 24 |
| 8 | Adage Capital Partners Gp LLC | 5.50M (4.21%) | 4.00M Increased by +72.73% | Dec 31, 25 |
| 9 | Bain Capital Life Sciences Investors, LLC | 5.25M (4.02%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 10 | Bellevue Group AG | 5.16M (3.95%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 11 | Sio Capital Management, LLC | 4.10M (3.13%) | 697.98K Increased by +17.04% | Jun 30, 25 |
| 12 | Woodline Partners LP | 4.00M (3.06%) | 1.36M Increased by +34.04% | Dec 31, 25 |
| 13 | Balyasny Asset Management LLC | 3.30M (2.52%) | 2.00M Increased by +60.68% | Dec 31, 25 |
| 14 | Longaeva Partners L.P. | 3.10M (2.37%) | 3.10M Increased by +100.00% | Dec 31, 25 |
| 15 | Morgan Stanley - Brokerage Accounts | 3.03M (2.32%) | 2.20M Increased by +72.52% | Sep 30, 25 |
| 16 | Mak Capital One LLC | 2.96M (2.26%) | 2.96M Increased by +100.00% | Dec 31, 25 |
| 17 | Nuveen, LLC | 2.92M (2.23%) | 2.23M Increased by +76.59% | Dec 31, 25 |
| 18 | Geode Capital Management, LLC | 2.90M (2.22%) | 465.95K Increased by +16.05% | Dec 31, 25 |
| 19 | Millennium Management LLC | 2.84M (2.17%) | 14.03K Increased by +0.49% | Dec 31, 25 |
| 20 | Nuveen Asset Management, LLC | 2.72M (2.08%) | 164.91K Increased by +6.06% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BB Biotech AG Ord | 5.16M (3.95%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 2 | Fidelity Select Biotechnology | 4.63M (3.54%) | 865.50K Increased by +18.68% | Jan 31, 26 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 4.31M (3.30%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 4 | FIAM Small Cap Core Composite | 4.11M (3.15%) | 658.33K Increased by +16.01% | Sep 30, 25 |
| 5 | Vanguard US Total Market Shares ETF | 2.83M (2.16%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 6 | Candriam Eqs L Biotech C USD Cap | 2.58M (1.98%) | 49.35K Increased by +1.91% | Oct 31, 25 |
| 7 | FIAM Small Cap Core CIT Cl B | 2.43M (1.86%) | -444.00K Decreased by -18.25% | Dec 31, 25 |
| 8 | iShares Russell 2000 ETF | 2.42M (1.85%) | 2.42M Increased by +100.00% | Feb 28, 26 |
| 9 | Fidelity Growth Compy Commingled Pl O | 2.37M (1.82%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 10 | State Street® SPDR® S&P® Biotech ETF | 2.36M (1.80%) | 13.08K Increased by +0.55% | Feb 28, 26 |
| 11 | SPDR® S&P Biotech ETF | 2.32M (1.77%) | -14.13K Decreased by -0.61% | Feb 28, 25 |
| 12 | Fidelity Growth Compy Commingled Pl S | 1.85M (1.42%) | -604.61K Decreased by -32.68% | Jul 31, 25 |
| 13 | Columbia Acorn Inst | 1.79M (1.37%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 14 | CREF Total Global Stock Account R3 | 1.67M (1.27%) | 165.90K Increased by +9.96% | Jan 31, 26 |
| 15 | Vanguard Institutional Extnd Mkt Idx Tr | 1.48M (1.13%) | 17.62K Increased by +1.19% | Feb 28, 26 |
| 16 | Columbia Small Cap Value Discv A | 1.44M (1.10%) | 30.50K Increased by +2.12% | Feb 28, 26 |
| 17 | Columbia Small Cap Value Discovery Fund | 1.39M (1.06%) | 32.70K Increased by +2.35% | Dec 31, 25 |
| 18 | Columbia Small Cap Value I A | 1.36M (1.04%) | 37.30K Increased by +2.75% | Jul 31, 25 |
| 19 | Fidelity Small Cap Growth | 1.33M (1.02%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 20 | Columbia Small Cap Value I | 1.32M (1.01%) | 491.95K Increased by +37.26% | Jun 30, 25 |