| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Pfizer Inc | 22.03M (8.17%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | TPG GP A, LLC | 18.72M (6.94%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | BlackRock Inc | 17.68M (6.56%) | 161.35K Increased by +0.91% | Dec 31, 25 |
| 4 | Citadel Advisors Llc | 12.11M (4.49%) | -1.86M Decreased by -15.36% | Dec 31, 25 |
| 5 | Capital World Investors | 11.15M (4.14%) | -1.12M Decreased by -10.00% | Jun 30, 25 |
| 6 | Darwin Global Management, Ltd. | 10.48M (3.89%) | 30.00K Increased by +0.29% | Jun 30, 25 |
| 7 | Vanguard Group Inc | 9.25M (3.43%) | 230.84K Increased by +2.50% | Dec 31, 25 |
| 8 | State Street Corporation | 9.18M (3.41%) | 6.76M Increased by +73.57% | Mar 31, 24 |
| 9 | PRIMECAP Management Company | 8.38M (3.11%) | 240.00K Increased by +2.86% | Mar 31, 26 |
| 10 | FMR Inc | 7.39M (2.74%) | -16.38M Decreased by -221.50% | Mar 31, 25 |
| 11 | Goldman Sachs Group Inc | 5.50M (2.04%) | -350.83K Decreased by -6.38% | Jun 30, 25 |
| 12 | JPMorgan Chase & Co | 5.14M (1.91%) | 1.40M Increased by +27.27% | Mar 31, 25 |
| 13 | EcoR1 Capital, LLC | 4.49M (1.66%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 14 | Geode Capital Management, LLC | 3.93M (1.46%) | 99.03K Increased by +2.52% | Dec 31, 25 |
| 15 | Frazier Life Sciences Management, L.P. | 3.87M (1.43%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 16 | Boxer Capital LLC | 3.85M (1.43%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 17 | UBS Group AG | 3.57M (1.32%) | 1.53M Increased by +42.91% | Sep 30, 25 |
| 18 | Woodline Partners LP | 3.50M (1.30%) | -860.11K Decreased by -24.57% | Dec 31, 25 |
| 19 | Patient Square Capital LP | 3.45M (1.28%) | -1.51M Decreased by -43.88% | Mar 31, 26 |
| 20 | Two Sigma Investments LLC | 3.42M (1.27%) | 39.80K Increased by +1.16% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | American Funds SMALLCAP World A | 11.15M (4.14%) | -1.12M Decreased by -10.00% | Jun 30, 25 |
| 2 | State Street® SPDR® S&P® Biotech ETF | 5.95M (2.20%) | -42.12K Decreased by -0.71% | Apr 30, 26 |
| 3 | Vanguard Capital Opportunity Inv | 5.36M (1.99%) | 175.00K Increased by +3.26% | Mar 31, 26 |
| 4 | Vanguard Total Stock Mkt Idx Inv | 4.88M (1.81%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 5 | Fidelity Growth Compy Commingled Pl O | 4.58M (1.70%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 6 | Vanguard US Total Market Shares ETF | 4.34M (1.61%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 7 | Fidelity Select Health Care | 4.00M (1.48%) | -350.00K Decreased by -8.75% | Jan 31, 25 |
| 8 | SPDR® S&P Biotech ETF | 3.90M (1.45%) | -23.78K Decreased by -0.61% | Feb 28, 25 |
| 9 | T. Rowe Price Health Sciences | 3.83M (1.42%) | -181.74K Decreased by -4.74% | Mar 31, 26 |
| 10 | iShares Russell 2000 ETF | 3.68M (1.37%) | 31.07K Increased by +0.84% | Apr 30, 26 |
| 11 | Fidelity Series Small Cap Opps | 3.54M (1.31%) | -141.30K Decreased by -3.99% | Sep 30, 24 |
| 12 | Fidelity Advisor® Health Care I | 2.88M (1.07%) | 4.50K Increased by +0.16% | Nov 30, 23 |
| 13 | PRIMECAP Odyssey Aggressive Growth | 2.78M (1.03%) | 50.00K Increased by +1.80% | Mar 31, 26 |
| 14 | Fidelity Advisor Health Care I | 2.50M (0.93%) | -500.00K Decreased by -20.00% | Jan 31, 25 |
| 15 | BGF World Healthscience A2 USD | 2.47M (0.92%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 16 | Fidelity Growth Compy Commingled Pl S | 2.46M (0.91%) | -1.31M Decreased by -53.05% | Mar 31, 25 |
| 17 | BGF World Healthscience A2 | 2.44M (0.90%) | 2.44M Increased by +100.00% | Jan 31, 26 |
| 18 | Fidelity® Select Biotechnology | 2.28M (0.84%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 19 | Fidelity Stock Selector Small Cap | 2.13M (0.79%) | 143.60K Increased by +6.73% | Sep 30, 24 |
| 20 | abrdn Life Sciences Investors | 2.13M (0.79%) | 666.39K Increased by +31.31% | Apr 30, 26 |