| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Bvf Inc | 16.55M (32.18%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 2 | T. Rowe Price Associates, Inc. | 7.92M (15.40%) | 1.58M Increased by +19.93% | Dec 31, 23 |
| 3 | NEA Management Company, LLC | 6.15M (11.95%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 4 | Deep Track Capital, LP | 5.70M (11.09%) | 704.28K Increased by +12.35% | Dec 31, 24 |
| 5 | FMR Inc | 5.41M (10.52%) | 39.90K Increased by +0.74% | Dec 31, 24 |
| 6 | RiverVest Venture Management LLC | 4.99M (9.70%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 7 | Blackstone Inc | 4.10M (7.96%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 8 | Point72 Asset Management, L.P. | 3.59M (6.99%) | 1.84M Increased by +51.32% | Dec 31, 24 |
| 9 | Vanguard Group Inc | 3.43M (6.66%) | -86.21K Decreased by -2.51% | Dec 31, 24 |
| 10 | Redmile Group, LLC | 3.02M (5.86%) | -62.73K Decreased by -2.08% | Dec 31, 24 |
| 11 | Vivo Capital, LLC | 2.96M (5.75%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 12 | Logos Global Management LP | 2.90M (5.64%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 13 | Alta Partners Management Company, L.P. | 2.55M (4.95%) | 2.55M Increased by +100.00% | Dec 31, 24 |
| 14 | Opaleye Management Inc | 2.41M (4.68%) | -372.40K Decreased by -15.47% | Sep 30, 24 |
| 15 | Citadel Advisors Llc | 1.66M (3.22%) | -133.65K Decreased by -8.07% | Dec 31, 24 |
| 16 | BlackRock Inc | 1.44M (2.80%) | 168.05K Increased by +11.67% | Dec 31, 24 |
| 17 | State Street Corporation | 1.41M (2.73%) | 21.80K Increased by +1.55% | Mar 31, 24 |
| 18 | Acadian Asset Management LLC | 1.33M (2.59%) | 1.26M Increased by +94.60% | Mar 31, 24 |
| 19 | RA Capital Management, LLC | 1.13M (2.20%) | 1.13M Increased by +100.00% | Dec 31, 24 |
| 20 | Rock Springs Capital Management LP | 1.10M (2.14%) | -100.00K Decreased by -9.09% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity Advisor Biotechnology I | 4.86M (9.44%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 2 | T. Rowe Price New Horizons | 4.22M (8.21%) | 758.66K Increased by +17.96% | Dec 31, 23 |
| 3 | US Small-Cap Growth II Equity Comp | 4.22M (8.21%) | 758.66K Increased by +17.96% | Dec 31, 23 |
| 4 | Vanguard Total Stock Mkt Idx Inv | 2.34M (4.55%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 5 | Vanguard US Total Market Shares ETF | 2.34M (4.55%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 6 | iShares Russell 2000 ETF | 1.54M (2.99%) | -12.27K Decreased by -0.80% | Apr 30, 24 |
| 7 | HBM Healthcare Investments AG Ord | 1.50M (2.92%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 8 | T. Rowe Price Health Sciences | 1.23M (2.40%) | 569.94K Increased by +46.24% | Dec 31, 23 |
| 9 | Vanguard Institutional Extnd Mkt Idx Tr | 1.01M (1.96%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 10 | Fidelity Advisor® Biotechnology I | 989.11K (1.92%) | 989.11K Increased by +100.00% | Nov 30, 23 |
| 11 | T. Rowe Price New Horizons Tr-Z | 741.93K (1.44%) | 167.94K Increased by +22.64% | Dec 31, 23 |
| 12 | Fidelity Small Cap Index | 675.07K (1.31%) | 20.67K Increased by +3.06% | Jun 30, 24 |
| 13 | iShares Russell 2000 Value ETF | 637.98K (1.24%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 14 | Fidelity® Small Cap Index | 636.14K (1.24%) | 15.51K Increased by +2.44% | Oct 31, 23 |
| 15 | Xtrackers S&P Global Infra Swap ETF 1C | 629.16K (1.22%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 16 | Fidelity Extended Market Index | 434.59K (0.84%) | 16.66K Increased by +3.83% | Mar 31, 25 |
| 17 | Fidelity® Extended Market Index | 401.52K (0.78%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 18 | State St Russell Sm/Mid Cp® Indx NL Cl C | 362.57K (0.70%) | -140.43K Decreased by -38.73% | Jun 30, 24 |
| 19 | Vanguard Russell 2000 ETF | 252.53K (0.49%) | 8.03K Increased by +3.18% | Mar 31, 24 |
| 20 | State St Russell Sm Cap® Indx SL Cl I | 245.00K (0.48%) | 0.00 Increased by 0.00% | Apr 30, 24 |