| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Bvf Inc | 16.55M (28.67%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 2 | TANG CAPITAL MANAGEMENT LLC | 8.69M (15.06%) | 8.32M Increased by +95.65% | Mar 31, 25 |
| 3 | T. Rowe Price Associates, Inc. | 7.92M (13.72%) | 1.58M Increased by +19.93% | Dec 31, 23 |
| 4 | Deep Track Capital, LP | 7.23M (12.53%) | 1.53M Increased by +21.13% | Mar 31, 25 |
| 5 | NEA Management Company, LLC | 6.15M (10.65%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 6 | FMR Inc | 5.41M (9.37%) | 39.90K Increased by +0.74% | Dec 31, 24 |
| 7 | RiverVest Venture Management LLC | 4.99M (8.64%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 8 | Blackstone Inc | 4.10M (7.10%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 9 | Point72 Asset Management, L.P. | 3.59M (6.23%) | 1.84M Increased by +51.32% | Dec 31, 24 |
| 10 | Vanguard Group Inc | 3.43M (5.94%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 11 | Logos Global Management LP | 2.90M (5.02%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 12 | Alta Partners Management Company, L.P. | 2.55M (4.41%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 13 | Opaleye Management Inc | 2.41M (4.17%) | -372.40K Decreased by -15.47% | Sep 30, 24 |
| 14 | Citadel Advisors Llc | 1.66M (2.87%) | -133.65K Decreased by -8.07% | Dec 31, 24 |
| 15 | State Street Corporation | 1.41M (2.43%) | 21.80K Increased by +1.55% | Mar 31, 24 |
| 16 | Acadian Asset Management LLC | 1.33M (2.31%) | 1.26M Increased by +94.60% | Mar 31, 24 |
| 17 | BlackRock Inc | 1.27M (2.20%) | -171.42K Decreased by -13.51% | Mar 31, 25 |
| 18 | Ikarian Capital, LLC | 1.17M (2.03%) | 200.00K Increased by +17.07% | Mar 31, 25 |
| 19 | RA Capital Management, LLC | 1.13M (1.96%) | 1.13M Increased by +100.00% | Dec 31, 24 |
| 20 | Rock Springs Capital Management LP | 1.10M (1.91%) | -100.00K Decreased by -9.09% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity Advisor Biotechnology I | 4.86M (8.41%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 2 | T. Rowe Price New Horizons | 4.22M (7.31%) | 758.66K Increased by +17.96% | Dec 31, 23 |
| 3 | US Small-Cap Growth II Equity Comp | 4.22M (7.31%) | 758.66K Increased by +17.96% | Dec 31, 23 |
| 4 | Vanguard Total Stock Mkt Idx Inv | 2.34M (4.05%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 5 | Vanguard US Total Market Shares ETF | 2.34M (4.05%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 6 | iShares Russell 2000 ETF | 1.54M (2.66%) | -12.27K Decreased by -0.80% | Apr 30, 24 |
| 7 | HBM Healthcare Investments AG Ord | 1.50M (2.60%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 8 | T. Rowe Price Health Sciences | 1.23M (2.13%) | 569.94K Increased by +46.24% | Dec 31, 23 |
| 9 | Vanguard Institutional Extnd Mkt Idx Tr | 1.01M (1.75%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 10 | Fidelity Advisor® Biotechnology I | 989.11K (1.71%) | 989.11K Increased by +100.00% | Nov 30, 23 |
| 11 | T. Rowe Price New Horizons Tr-Z | 741.93K (1.28%) | 167.94K Increased by +22.64% | Dec 31, 23 |
| 12 | Fidelity Small Cap Index | 675.07K (1.17%) | 20.67K Increased by +3.06% | Jun 30, 24 |
| 13 | iShares Russell 2000 Value ETF | 637.98K (1.10%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 14 | Fidelity® Small Cap Index | 636.14K (1.10%) | 15.51K Increased by +2.44% | Oct 31, 23 |
| 15 | Xtrackers S&P Global Infra Swap ETF 1C | 629.16K (1.09%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 16 | Fidelity Extended Market Index | 430.47K (0.75%) | -4.11K Decreased by -0.96% | Apr 30, 25 |
| 17 | Fidelity® Extended Market Index | 401.52K (0.70%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 18 | State St Russell Sm/Mid Cp® Indx NL Cl C | 362.57K (0.63%) | -140.43K Decreased by -38.73% | Jun 30, 24 |
| 19 | Vanguard Russell 2000 ETF | 252.53K (0.44%) | 8.03K Increased by +3.18% | Mar 31, 24 |
| 20 | State St Russell Sm Cap® Indx SL Cl I | 245.00K (0.42%) | 0.00 Increased by 0.00% | Apr 30, 24 |