| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LLC | 7.42M (11.24%) | 559.52K Increased by +7.54% | Mar 31, 25 |
| 2 | HHG PLC | 7.07M (10.71%) | 1.03M Increased by +14.63% | Mar 31, 25 |
| 3 | BlackRock Inc | 6.26M (9.47%) | 330.84K Increased by +5.29% | Mar 31, 25 |
| 4 | Wellington Management Company LLP | 5.94M (8.99%) | -1.44M Decreased by -24.27% | Mar 31, 25 |
| 5 | General Atlantic Llc | 5.23M (7.93%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 6 | T. Rowe Price Associates, Inc. | 4.32M (6.55%) | 513.61K Increased by +11.88% | Dec 31, 24 |
| 7 | Vanguard Group Inc | 4.23M (6.41%) | 526.23K Increased by +12.44% | Mar 31, 25 |
| 8 | State Street Corporation | 3.80M (5.75%) | -1.33M Decreased by -34.89% | Mar 31, 24 |
| 9 | Deep Track Capital, LP | 3.21M (4.86%) | 1.72M Increased by +53.59% | Mar 31, 25 |
| 10 | State Street Corp | 2.49M (3.78%) | 158.80K Increased by +6.37% | Mar 31, 25 |
| 11 | Adage Capital Partners Gp LLC | 1.94M (2.94%) | -1.11M Decreased by -56.92% | Sep 30, 23 |
| 12 | Morgan Stanley - Brokerage Accounts | 1.89M (2.87%) | 1.09M Increased by +57.33% | Jun 30, 24 |
| 13 | AllianceBernstein L.P. | 1.84M (2.79%) | -177.81K Decreased by -9.67% | Dec 31, 24 |
| 14 | Boxer Capital LLC | 1.68M (2.54%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 15 | Geode Capital Management, LLC | 1.56M (2.36%) | -11.38K Decreased by -0.73% | Dec 31, 24 |
| 16 | Alkeon Capital Management, LLC | 1.55M (2.35%) | -210.33K Decreased by -13.56% | Mar 31, 25 |
| 17 | Citadel Advisors Llc | 1.35M (2.05%) | 1.20M Increased by +88.94% | Dec 31, 24 |
| 18 | Fred Alger Management, LLC | 1.34M (2.03%) | 1.25M Increased by +93.21% | Mar 31, 24 |
| 19 | T. Rowe Price Investment Management,Inc. | 1.30M (1.97%) | -467.15K Decreased by -35.93% | Sep 30, 24 |
| 20 | Redmile Group, LLC | 1.24M (1.87%) | -152.27K Decreased by -12.33% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Health Care Inv | 3.66M (5.54%) | -743.67K Decreased by -20.33% | Mar 31, 25 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 2.29M (3.48%) | 166.68K Increased by +7.27% | Mar 31, 25 |
| 3 | Vanguard US Total Market Shares ETF | 1.94M (2.94%) | 2.50K Increased by +0.13% | Sep 30, 24 |
| 4 | iShares Russell 2000 ETF | 1.84M (2.78%) | 310.00 Increased by +0.02% | Apr 30, 25 |
| 5 | T. Rowe Price New Horizons | 1.81M (2.74%) | -24.48K Decreased by -1.35% | Mar 31, 25 |
| 6 | US Small-Cap Growth II Equity Comp | 1.81M (2.74%) | 29.50K Increased by +1.63% | Mar 31, 25 |
| 7 | Janus Henderson Global Life Sciences | 1.64M (2.48%) | -378.12K Decreased by -23.12% | Dec 31, 24 |
| 8 | Janus Henderson Global Life Sciences D | 1.55M (2.35%) | -3.78K Decreased by -0.24% | Mar 31, 25 |
| 9 | Janus Selection Global Life Science AUSD | 1.55M (2.34%) | 94.70K Increased by +6.12% | Jun 30, 24 |
| 10 | Janus Global Life Science AUSD | 1.26M (1.91%) | -43.35K Decreased by -3.45% | Mar 31, 25 |
| 11 | Janus Henderson Glb Life Scn I2 USD | 1.26M (1.91%) | -1.16K Decreased by -0.09% | Mar 31, 25 |
| 12 | T. Rowe Price Health Sciences | 1.24M (1.88%) | -18.77K Decreased by -1.51% | Mar 31, 25 |
| 13 | Vanguard Institutional Extnd Mkt Idx Tr | 1.08M (1.63%) | 27.93K Increased by +2.60% | Mar 31, 25 |
| 14 | SPDR® S&P Biotech ETF | 885.55K (1.34%) | -12.96K Decreased by -1.46% | Apr 30, 25 |
| 15 | Janus Henderson US SMID Cap Growth | 758.39K (1.15%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 16 | Fidelity Small Cap Index | 672.41K (1.02%) | 4.33K Increased by +0.64% | Feb 28, 25 |
| 17 | Pictet-Biotech P USD | 630.78K (0.96%) | -2.99K Decreased by -0.47% | Jul 31, 23 |
| 18 | iShares Russell 2000 Value ETF | 583.13K (0.88%) | -1.98K Decreased by -0.34% | Apr 30, 25 |
| 19 | AB Small Cap Growth A | 532.20K (0.81%) | -12.02K Decreased by -2.26% | Dec 31, 24 |
| 20 | iShares Russell 2000 Growth ETF | 521.27K (0.79%) | -1.25K Decreased by -0.24% | Apr 30, 24 |