| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Redmile Group, LLC | 15.67M (15.60%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | TCG Crossover Management, LLC | 11.39M (11.34%) | 10.00M Increased by +87.79% | Dec 31, 25 |
| 3 | Prosight Management, LP | 8.48M (8.44%) | 1.01M Increased by +11.86% | Dec 31, 25 |
| 4 | Orbimed Advisors, LLC | 5.82M (5.80%) | -84.50K Decreased by -1.45% | Dec 31, 25 |
| 5 | Nantahala Capital Management, LLC | 5.48M (5.45%) | 3.21M Increased by +58.61% | Dec 31, 25 |
| 6 | BlackRock Inc | 5.43M (5.41%) | 915.61K Increased by +16.87% | Dec 31, 25 |
| 7 | Point72 Asset Management, L.P. | 5.01M (4.99%) | -3.12M Decreased by -62.24% | Dec 31, 25 |
| 8 | Morgan Stanley - Brokerage Accounts | 3.77M (3.75%) | 100.68K Increased by +2.67% | Dec 31, 25 |
| 9 | Eventide Asset Management, LLC | 3.36M (3.35%) | 3.36M Increased by +100.00% | Dec 31, 25 |
| 10 | Sio Capital Management, LLC | 3.29M (3.28%) | -726.17K Decreased by -22.04% | Sep 30, 23 |
| 11 | Heights Capital Management Inc | 2.83M (2.82%) | 2.83M Increased by +100.00% | Jun 30, 25 |
| 12 | SILVERARC CAPITAL MANAGEMENT, LLC | 1.80M (1.79%) | 26.31K Increased by +1.47% | Sep 30, 24 |
| 13 | The Goldman Sachs Group Inc | 1.64M (1.63%) | 46.44K Increased by +2.83% | Dec 31, 25 |
| 14 | Goldman Sachs Group Inc | 1.54M (1.54%) | -40.51K Decreased by -2.63% | Jun 30, 25 |
| 15 | State Street Corp | 1.41M (1.40%) | 111.38K Increased by +7.91% | Dec 31, 25 |
| 16 | Lynx1 Capital Management, LP | 1.33M (1.32%) | 1.33M Increased by +100.00% | Sep 30, 25 |
| 17 | Bank of America Corp | 1.30M (1.29%) | -62.71K Decreased by -4.83% | Dec 31, 25 |
| 18 | Junked Platinum Investment Management Ltd | 1.16M (1.15%) | -230.54K Decreased by -19.93% | Sep 30, 25 |
| 19 | Vanguard Group Inc | 1.13M (1.12%) | 535.63K Increased by +47.42% | Dec 31, 25 |
| 20 | AlphaCentric Advisors, LLC | 1.07M (1.06%) | 290.47K Increased by +27.19% | Sep 30, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Eventide Healthcare & Life Sciences I | 3.36M (3.35%) | 3.36M Increased by +100.00% | Dec 31, 25 |
| 2 | iShares Russell 2000 ETF | 2.34M (2.33%) | -11.02K Decreased by -0.47% | Apr 29, 26 |
| 3 | Biotech Growth Ord | 1.88M (1.87%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 4 | Fidelity Small Cap Index | 841.26K (0.84%) | 7.41K Increased by +0.88% | Feb 28, 26 |
| 5 | iShares Russell 2000 Growth ETF | 829.02K (0.83%) | 0.00 Increased by 0.00% | Apr 29, 26 |
| 6 | Pictet-Global Megatrend Sel I USD | 681.58K (0.68%) | 7.34K Increased by +1.08% | May 31, 23 |
| 7 | iShares Biotechnology ETF | 659.14K (0.66%) | -5.60K Decreased by -0.85% | Apr 29, 26 |
| 8 | State St Russell Sm/Mid Cp® Indx SL Cl I | 608.04K (0.61%) | 93.30K Increased by +15.34% | Mar 31, 26 |
| 9 | Pictet-Biotech P USD | 588.57K (0.59%) | 6.33K Increased by +1.08% | May 31, 23 |
| 10 | Russell 2000 Equity Index Fund B | 571.78K (0.57%) | 88.32K Increased by +15.45% | Dec 31, 25 |
| 11 | Vanguard Russell 2000 ETF | 501.95K (0.50%) | 75.40K Increased by +15.02% | Mar 31, 26 |
| 12 | International Biotechnology Ord | 418.78K (0.42%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 13 | State St Russell Sm/Mid Cp® Indx NL Cl C | 401.24K (0.40%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 14 | State St Russell Sm Cap® Indx SL Cl I | 319.50K (0.32%) | 15.30K Increased by +4.79% | Mar 31, 26 |
| 15 | Vanguard US Momentum Factor ETF | 316.58K (0.32%) | -85.29K Decreased by -26.94% | Mar 31, 26 |
| 16 | iShares Russell 2000 Value ETF | 286.42K (0.29%) | 0.00 Increased by 0.00% | May 31, 25 |
| 17 | iShares Micro-Cap ETF | 261.89K (0.26%) | 1.71K Increased by +0.65% | Apr 29, 26 |
| 18 | Schwab Small Cap Index | 224.36K (0.22%) | 33.17K Increased by +14.78% | Mar 31, 26 |
| 19 | Lazard Baylight US Small Cap Equity | 220.38K (0.22%) | 220.38K Increased by +100.00% | Mar 31, 26 |
| 20 | NT R2000 Index Fund - NL | 218.44K (0.22%) | 28.34K Increased by +12.97% | Mar 31, 26 |