| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BML Capital Management LLC | 14.25M (17.06%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | Vivo Capital, LLC | 8.89M (10.64%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | Bvf Inc | 7.06M (8.46%) | 3.70M Increased by +52.43% | Sep 30, 23 |
| 4 | Wellington Management Company LLP | 6.98M (8.36%) | -658.02K Decreased by -9.43% | Sep 30, 23 |
| 5 | Vanguard Group Inc | 6.50M (7.79%) | -13.38K Decreased by -0.21% | Dec 31, 25 |
| 6 | BlackRock Inc | 5.69M (6.81%) | 176.47K Increased by +3.10% | Sep 30, 25 |
| 7 | RA Capital Management, LLC | 4.67M (5.59%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 8 | Rock Springs Capital Management LP | 4.45M (5.33%) | -155.57K Decreased by -3.49% | Dec 31, 25 |
| 9 | Morgan Stanley - Brokerage Accounts | 4.08M (4.88%) | 537.05K Increased by +13.17% | Sep 30, 25 |
| 10 | Decheng Capital LLC | 4.04M (4.84%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 11 | Adage Capital Partners Gp LLC | 3.37M (4.04%) | -1.91M Decreased by -56.58% | Dec 31, 25 |
| 12 | Foresite Capital Management IV, LLC | 2.81M (3.36%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 13 | HHG PLC | 2.80M (3.35%) | 2.80M Increased by +100.00% | Dec 31, 24 |
| 14 | Stonepine Capital Management Llc | 2.46M (2.94%) | 531.43K Increased by +21.61% | Sep 30, 24 |
| 15 | Geode Capital Management, LLC | 2.39M (2.87%) | 3.24K Increased by +0.14% | Dec 31, 25 |
| 16 | Samsara BioCapital, LLC | 2.39M (2.86%) | 1.69M Increased by +70.81% | Dec 31, 24 |
| 17 | Acadian Asset Management LLC | 2.33M (2.79%) | 2.33M Increased by +99.97% | Sep 30, 25 |
| 18 | D. E. Shaw & Co LP | 2.10M (2.51%) | -276.57K Decreased by -13.19% | Dec 31, 25 |
| 19 | Trium Capital LLP | 1.91M (2.29%) | 20.94K Increased by +1.09% | Sep 30, 24 |
| 20 | Velan Capital Investment Management LP | 1.76M (2.11%) | 1.76M Increased by +100.00% | Dec 31, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 3.97M (4.75%) | 802.10K Increased by +20.21% | Mar 31, 26 |
| 2 | iShares Russell 2000 ETF | 2.25M (2.70%) | -18.42K Decreased by -0.82% | Mar 31, 26 |
| 3 | Vanguard US Total Market Shares ETF | 2.12M (2.53%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | Vanguard Institutional Extnd Mkt Idx Tr | 1.10M (1.31%) | 14.81K Increased by +1.35% | Mar 31, 26 |
| 5 | Xtrackers S&P 500 Swap ETF 1C | 916.55K (1.10%) | -6.76K Decreased by -0.74% | Dec 31, 25 |
| 6 | Fidelity Small Cap Index | 894.78K (1.07%) | -11.65K Decreased by -1.30% | Jan 31, 26 |
| 7 | iShares Russell 2000 Value ETF | 804.81K (0.96%) | 0.00 Increased by 0.00% | Mar 31, 26 |
| 8 | iShares Biotechnology ETF | 767.60K (0.92%) | 1.59K Increased by +0.21% | Mar 31, 26 |
| 9 | Fidelity® Small Cap Index | 671.70K (0.80%) | 20.07K Increased by +2.99% | Oct 31, 23 |
| 10 | Vanguard Strategic Small-Cap Equity Inv | 592.57K (0.71%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 11 | iShares Russell 2000 Growth ETF | 587.67K (0.70%) | 0.00 Increased by 0.00% | May 29, 24 |
| 12 | Russell 2000 Equity Index Fund B | 559.11K (0.67%) | 29.00 Increased by +0.01% | Dec 31, 25 |
| 13 | State St Russell Sm/Mid Cp® Indx SL Cl I | 544.74K (0.65%) | 203.80K Increased by +37.41% | Mar 31, 26 |
| 14 | Fidelity Extended Market Index | 516.58K (0.62%) | -1.87K Decreased by -0.36% | Feb 28, 26 |
| 15 | SQUAD Aguja Opportunities I | 500.00K (0.60%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 16 | Vanguard Russell 2000 ETF | 450.38K (0.54%) | -5.54K Decreased by -1.23% | Mar 31, 26 |
| 17 | Fidelity® Extended Market Index | 336.96K (0.40%) | 33.29K Increased by +9.88% | Nov 30, 23 |
| 18 | State St Russell Sm Cap® Indx SL Cl I | 318.50K (0.38%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 19 | JPMorgan Small Cap Value I | 298.02K (0.36%) | -6.21K Decreased by -2.08% | Feb 28, 26 |
| 20 | Vanguard VIF Small Co Gr | 282.35K (0.34%) | 0.00 Increased by 0.00% | Dec 31, 25 |