| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BML Capital Management LLC | 14.25M (15.11%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | Vivo Capital, LLC | 8.89M (9.42%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | Bvf Inc | 7.06M (7.49%) | 3.70M Increased by +52.43% | Sep 30, 23 |
| 4 | Wellington Management Company LLP | 6.98M (7.40%) | -658.02K Decreased by -9.43% | Sep 30, 23 |
| 5 | Vanguard Group Inc | 6.50M (6.89%) | -13.38K Decreased by -0.21% | Dec 31, 25 |
| 6 | BlackRock Inc | 5.69M (6.03%) | 176.47K Increased by +3.10% | Sep 30, 25 |
| 7 | RA Capital Management, LLC | 4.67M (4.95%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 8 | Rock Springs Capital Management LP | 4.45M (4.72%) | -155.57K Decreased by -3.49% | Dec 31, 25 |
| 9 | Morgan Stanley - Brokerage Accounts | 4.08M (4.32%) | 537.05K Increased by +13.17% | Sep 30, 25 |
| 10 | Decheng Capital LLC | 4.04M (4.29%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 11 | Adage Capital Partners Gp LLC | 3.37M (3.57%) | -1.91M Decreased by -56.58% | Dec 31, 25 |
| 12 | Foresite Capital Management IV, LLC | 2.81M (2.98%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 13 | HHG PLC | 2.80M (2.97%) | 2.80M Increased by +100.00% | Dec 31, 24 |
| 14 | Stonepine Capital Management Llc | 2.46M (2.61%) | 531.43K Increased by +21.61% | Sep 30, 24 |
| 15 | Geode Capital Management, LLC | 2.39M (2.53%) | -75.25K Decreased by -3.15% | Sep 30, 25 |
| 16 | Samsara BioCapital, LLC | 2.39M (2.53%) | 1.69M Increased by +70.81% | Dec 31, 24 |
| 17 | Acadian Asset Management LLC | 2.33M (2.47%) | 2.33M Increased by +99.97% | Sep 30, 25 |
| 18 | D. E. Shaw & Co LP | 2.10M (2.22%) | -276.57K Decreased by -13.19% | Dec 31, 25 |
| 19 | Trium Capital LLP | 1.91M (2.03%) | 20.94K Increased by +1.09% | Sep 30, 24 |
| 20 | Velan Capital Investment Management LP | 1.76M (1.87%) | 1.76M Increased by +100.00% | Dec 31, 23 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 3.17M (3.36%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 2 | iShares Russell 2000 ETF | 2.22M (2.35%) | 963.24K Increased by +43.45% | Feb 25, 26 |
| 3 | Vanguard US Total Market Shares ETF | 2.12M (2.24%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | Vanguard Institutional Extnd Mkt Idx Tr | 1.11M (1.17%) | 4.09K Increased by +0.37% | Jan 31, 26 |
| 5 | Fidelity Small Cap Index | 921.97K (0.98%) | -1.10K Decreased by -0.12% | Nov 30, 25 |
| 6 | Xtrackers S&P 500 Swap ETF 1C | 916.55K (0.97%) | -6.76K Decreased by -0.74% | Dec 31, 25 |
| 7 | iShares Russell 2000 Value ETF | 798.85K (0.85%) | 798.85K Increased by +100.00% | Feb 25, 26 |
| 8 | iShares Biotechnology ETF | 684.01K (0.73%) | 219.19K Increased by +32.04% | Feb 25, 26 |
| 9 | Fidelity® Small Cap Index | 671.70K (0.71%) | 20.07K Increased by +2.99% | Oct 31, 23 |
| 10 | Vanguard Strategic Small-Cap Equity Inv | 592.57K (0.63%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 11 | iShares Russell 2000 Growth ETF | 587.67K (0.62%) | 0.00 Increased by 0.00% | May 29, 24 |
| 12 | Fidelity Extended Market Index | 520.60K (0.55%) | 6.30K Increased by +1.21% | Dec 31, 25 |
| 13 | SQUAD Aguja Opportunities I | 500.00K (0.53%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 14 | Vanguard Russell 2000 ETF | 436.72K (0.46%) | -15.20K Decreased by -3.48% | Jan 31, 26 |
| 15 | iShares Core S&P Total US Stock Mkt ETF | 373.94K (0.40%) | 339.17K Increased by +90.70% | Feb 25, 26 |
| 16 | Fidelity® Extended Market Index | 336.96K (0.36%) | 33.29K Increased by +9.88% | Nov 30, 23 |
| 17 | State St Russell Sm Cap® Indx SL Cl I | 318.50K (0.34%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 18 | JPMorgan Small Cap Value I | 310.95K (0.33%) | 75.31K Increased by +24.22% | Dec 31, 25 |
| 19 | State St Russell Sm/Mid Cp® Indx SL Cl I | 295.29K (0.31%) | 295.29K Increased by +100.00% | Jan 31, 26 |
| 20 | Vanguard VIF Small Co Gr | 282.35K (0.30%) | 0.00 Increased by 0.00% | Dec 31, 25 |