| Transaction Date | Reporting Name | Type of Owner | Transacted | Owned | Price | Transaction Type | Security Name |
|---|---|---|---|---|---|---|---|
| Sep 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 500.00 | 150.26 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Sep 7, 23 | Dake Benjamin T | officer: SEE REMARKS | 30.00 | 150.23 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Sep 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 1.02 K | 19.35 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Sep 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 1.51 K | 16.57 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| Sep 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 1.52 K | 5.22 K | 2.14 | Exempt | Common Stock |
| Sep 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 2.41 K | 3.70 K | 1.74 | Exempt | Common Stock |
| Sep 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 906.00 | 3.62 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| Sep 7, 23 | Dake Benjamin T | officer: SEE REMARKS | 30.00 | 1.32 K | 2.14 | Exempt | Common Stock |
| Sep 7, 23 | Dake Benjamin T | officer: SEE REMARKS | 30.00 Decreased by -2.27% | 1.29 K | 15.01 | Sale | Common Stock |
| Sep 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 3.93 K Decreased by -75.28% | 1.29 K | 15.06 | Sale | Common Stock |
| Aug 7, 23 | Dake Benjamin T | officer: SEE REMARKS | 6.85 K | 150.76 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Aug 7, 23 | Dake Benjamin T | officer: SEE REMARKS | 1.02 K | 20.37 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Aug 7, 23 | Dake Benjamin T | officer: SEE REMARKS | 1.51 K | 18.08 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| Aug 7, 23 | Dake Benjamin T | officer: SEE REMARKS | 7.87 K | 11.57 K | 2.14 | Exempt | Common Stock |
| Aug 7, 23 | Dake Benjamin T | officer: SEE REMARKS | 905.00 | 4.53 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| Aug 7, 23 | Dake Benjamin T | officer: SEE REMARKS | 2.41 K | 3.70 K | 1.74 | Exempt | Common Stock |
| Aug 7, 23 | Dake Benjamin T | officer: SEE REMARKS | 9.74 K Decreased by -84.17% | 1.83 K | 15.48 | Sale | Common Stock |
| Aug 7, 23 | Dake Benjamin T | officer: SEE REMARKS | 541.00 Decreased by -29.53% | 1.29 K | 16.25 | Sale | Common Stock |
| Jul 28, 23 | NOYES TIMOTHY P | director, officer: CHIEF EXECUTIVE OFFICER | 5.48 K | 383.38 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Jul 28, 23 | NOYES TIMOTHY P | director, officer: CHIEF EXECUTIVE OFFICER | 5.48 K | 5.48 K | 2.14 | Exempt | Common Stock |
| Jul 28, 23 | NOYES TIMOTHY P | director, officer: CHIEF EXECUTIVE OFFICER | 5.48 K Decreased by -100.00% | 0.00 | 18.00 | Sale | Common Stock |
| Jul 17, 23 | NOYES TIMOTHY P | director, officer: CHIEF EXECUTIVE OFFICER | 4.52 K | 388.86 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Jul 17, 23 | NOYES TIMOTHY P | director, officer: CHIEF EXECUTIVE OFFICER | 4.52 K | 4.52 K | 2.14 | Exempt | Common Stock |
| Jul 17, 23 | NOYES TIMOTHY P | director, officer: CHIEF EXECUTIVE OFFICER | 4.52 K Decreased by -100.00% | 0.00 | 18.11 | Sale | Common Stock |
| Jul 10, 23 | Dable Habib J | director | 25.00 K Increased by +N/A% | 25.00 K | 18.08 | Award | Stock Option (Right to Buy) |
| Jul 10, 23 | Dable Habib J | 0.00 | 0.00 | 0.00 | |||
| Jul 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 6.85 K | 157.61 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Jul 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 1.02 K | 21.39 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Jul 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 1.51 K | 19.59 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| Jul 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 7.87 K | 11.57 K | 2.14 | Exempt | Common Stock |
| Jul 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 906.00 | 5.43 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| Jul 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 2.41 K | 3.70 K | 1.74 | Exempt | Common Stock |
| Jul 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 10.28 K Decreased by -88.85% | 1.29 K | 16.66 | Sale | Common Stock |
| Jul 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 750.00 | 50.73 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Jul 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 650.00 | 42.11 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Jul 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 450.00 | 18.71 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| Jul 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 200.00 | 13.89 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Jul 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 200.00 | 12.09 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| Jul 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 1.60 K | 3.86 K | 2.14 | Exempt | Common Stock |
| Jul 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 650.00 | 2.26 K | 1.74 | Exempt | Common Stock |
| Jul 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 2.03 K Decreased by -52.63% | 1.83 K | 17.23 | Sale | Common Stock |
| Jul 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 219.00 Decreased by -11.98% | 1.61 K | 17.87 | Sale | Common Stock |
| Jul 3, 23 | NOYES TIMOTHY P | director, officer: CHIEF EXECUTIVE OFFICER | 10.00 K | 393.38 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Jul 3, 23 | NOYES TIMOTHY P | director, officer: CHIEF EXECUTIVE OFFICER | 10.00 K | 10.00 K | 2.14 | Exempt | Common Stock |
| Jul 3, 23 | NOYES TIMOTHY P | director, officer: CHIEF EXECUTIVE OFFICER | 10.00 K Decreased by -100.00% | 0.00 | 18.00 | Sale | Common Stock |
| Jun 6, 23 | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | 12.50 K Increased by +N/A% | 12.50 K | 16.30 | Award | Stock Option (Right to Buy) |
| Jun 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 6.85 K | 164.46 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Jun 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 1.02 K | 22.41 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Jun 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 1.51 K | 21.09 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| Jun 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 7.87 K | 11.57 K | 2.14 | Exempt | Common Stock |
| Jun 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 905.00 | 6.34 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| Jun 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 2.41 K | 3.70 K | 1.74 | Exempt | Common Stock |
| Jun 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 10.27 K Decreased by -88.72% | 1.31 K | 16.28 | Sale | Common Stock |
| Jun 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 15.00 Decreased by -1.15% | 1.29 K | 16.98 | Sale | Common Stock |
| Jun 6, 23 | Santel Donald J | director | 12.50 K Increased by +N/A% | 12.50 K | 16.30 | Award | Stock Option (Right to Buy) |
| Jun 6, 23 | Katabi Maha | director, 10 percent owner: | 12.50 K Increased by +N/A% | 12.50 K | 16.30 | Award | Stock Option (Right to Buy) |
| Jun 6, 23 | GRAYZEL DAVID S. | director | 12.50 K Increased by +N/A% | 12.50 K | 16.30 | Award | Stock Option (Right to Buy) |
| Jun 6, 23 | Resnick Joshua | director | 12.50 K Increased by +N/A% | 12.50 K | 16.30 | Award | Stock Option (Right to Buy) |
| Jun 6, 23 | Iwicki Mark T | director | 12.50 K Increased by +N/A% | 12.50 K | 16.30 | Award | Stock Option (Right to Buy) |
| Jun 6, 23 | Dorval Allison | director | 12.50 K Increased by +N/A% | 12.50 K | 16.30 | Award | Stock Option (Right to Buy) |
| Jun 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 750.00 | 51.48 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Jun 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 650.00 | 42.76 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Jun 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 450.00 | 19.16 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| Jun 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 200.00 | 14.09 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| Jun 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 200.00 | 12.29 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| Jun 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 1.60 K | 3.86 K | 2.14 | Exempt | Common Stock |
| Jun 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 650.00 | 2.26 K | 1.74 | Exempt | Common Stock |
| Jun 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 2.25 K Decreased by -58.31% | 1.61 K | 16.26 | Sale | Common Stock |
| May 19, 23 | Gillies Hunter | officer: CHIEF MEDICAL OFFICER | 65.00 | 18.95 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| May 19, 23 | Gillies Hunter | officer: CHIEF MEDICAL OFFICER | 65.00 | 3.32 K | 1.74 | Exempt | Common Stock |
| May 19, 23 | Gillies Hunter | officer: CHIEF MEDICAL OFFICER | 65.00 Decreased by -1.96% | 3.25 K | 19.50 | Sale | Common Stock |
| May 17, 23 | Gillies Hunter | officer: CHIEF MEDICAL OFFICER | 1.09 K | 19.02 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| May 17, 23 | Gillies Hunter | officer: CHIEF MEDICAL OFFICER | 1.09 K | 4.34 K | 1.74 | Exempt | Common Stock |
| May 17, 23 | Gillies Hunter | officer: CHIEF MEDICAL OFFICER | 1.09 K Decreased by -25.11% | 3.25 K | 19.59 | Sale | Common Stock |
| May 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 750.00 | 52.23 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| May 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 650.00 | 43.41 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| May 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 450.00 | 19.61 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| May 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 200.00 | 14.29 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| May 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 200.00 | 12.49 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| May 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 1.60 K | 3.86 K | 2.14 | Exempt | Common Stock |
| May 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 650.00 | 2.26 K | 1.74 | Exempt | Common Stock |
| May 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 2.04 K Decreased by -52.99% | 1.81 K | 20.79 | Sale | Common Stock |
| May 5, 23 | NIVEN RALPH | officer: CHIEF SCIENTIFIC OFFICER | 205.00 Decreased by -11.30% | 1.61 K | 21.63 | Sale | Common Stock |
| May 8, 23 | Dake Benjamin T | officer: SEE REMARKS | 6.85 K | 171.31 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| May 8, 23 | Dake Benjamin T | officer: SEE REMARKS | 1.02 K | 23.42 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| May 8, 23 | Dake Benjamin T | officer: SEE REMARKS | 1.51 K | 22.60 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| May 8, 23 | Dake Benjamin T | officer: SEE REMARKS | 7.87 K | 11.57 K | 2.14 | Exempt | Common Stock |
| May 8, 23 | Dake Benjamin T | officer: SEE REMARKS | 906.00 | 7.24 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| May 8, 23 | Dake Benjamin T | officer: SEE REMARKS | 2.41 K | 3.70 K | 1.74 | Exempt | Common Stock |
| May 8, 23 | Dake Benjamin T | officer: SEE REMARKS | 8.69 K Decreased by -75.03% | 2.89 K | 21.62 | Sale | Common Stock |
| May 8, 23 | Dake Benjamin T | officer: SEE REMARKS | 1.60 K Decreased by -55.33% | 1.29 K | 22.74 | Sale | Common Stock |
| May 3, 23 | Verwijs Marinus | officer: SENIOR VICE PRESIDENT, CMC | 759.00 Decreased by -100.00% | 0.00 | 20.79 | Sale | Common Stock |
| May 1, 23 | NOYES TIMOTHY P | director, officer: CHIEF EXECUTIVE OFFICER | 15.00 K | 403.38 K | 2.14 | Exempt | Stock Option (Right to Buy) |
| May 1, 23 | NOYES TIMOTHY P | director, officer: CHIEF EXECUTIVE OFFICER | 15.00 K | 15.69 K | 2.14 | Exempt | Common Stock |
| May 1, 23 | NOYES TIMOTHY P | director, officer: CHIEF EXECUTIVE OFFICER | 15.00 K Decreased by -95.58% | 693.00 | 20.61 | Sale | Common Stock |
| May 2, 23 | NOYES TIMOTHY P | director, officer: CHIEF EXECUTIVE OFFICER | 693.00 Decreased by -100.00% | 0.00 | 21.15 | Sale | Common Stock |
| Apr 21, 23 | Gillies Hunter | officer: CHIEF MEDICAL OFFICER | 4.00 K | 20.11 K | 1.74 | Exempt | Stock Option (Right to Buy) |
| Apr 21, 23 | Gillies Hunter | officer: CHIEF MEDICAL OFFICER | 4.00 K | 5.96 K | 1.74 | Exempt | Common Stock |
| Apr 21, 23 | Gillies Hunter | officer: CHIEF MEDICAL OFFICER | 4.00 K Decreased by -67.11% | 1.96 K | 19.50 | Sale | Common Stock |
| Apr 6, 23 | Dake Benjamin T | officer: SEE REMARKS | 6.85 K | 178.17 K | 2.14 | Exempt | Stock Option (Right to Buy) |